Curated HPA-Axis Models

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A mechanistic model of ACTH-stimulated cortisol secretion

Although this model is bit old, it can capture mechanistic behavior of the ACTH stimulated cortisol secretion. GPCR signaling part is very much outdated and model does not consider the cholesterol uptake through LDL receptors pathway which is crucial for maximal steroid production



  1. Dempsher DP, Gann DS, and Phair RD. . pmid:6326602. PubMed HubMed [Dempsher_Gann_Phair_1984]
  2. Kraemer FB, Shen WJ, Patel S, Osuga J, Ishibashi S, and Azhar S. . pmid:16985254. PubMed HubMed [Kraemer_others_2007]
All Medline abstracts: PubMed HubMed
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