Curated HPA-Axis Models

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A mechanistic model of ACTH-stimulated cortisol secretion

Although this model is bit old, it can capture mechanistic behavior of the ACTH stimulated cortisol secretion. GPCR signaling part is very much outdated and model does not consider the cholesterol uptake through LDL receptors pathway which is crucial for maximal steroid production



  1. Dempsher DP, Gann DS, and Phair RD. A mechanistic model of ACTH-stimulated cortisol secretion. Am J Physiol. 1984 Apr;246(4 Pt 2):R587-96. DOI:10.1152/ajpregu.1984.246.4.R587 | PubMed ID:6326602 | HubMed [Dempsher_Gann_Phair_1984]
  2. Kraemer FB, Shen WJ, Patel S, Osuga J, Ishibashi S, and Azhar S. The LDL receptor is not necessary for acute adrenal steroidogenesis in mouse adrenocortical cells. Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E408-12. DOI:10.1152/ajpendo.00428.2006 | PubMed ID:16985254 | HubMed [Kraemer_others_2007]

All Medline abstracts: PubMed | HubMed

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