Curated HPA-Axis Models

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A mechanistic model of ACTH-stimulated cortisol secretion

Although this model [1] is bit old, it can capture mechanistic behavior of the ACTH stimulated cortisol secretion. GPCR signaling part is very much outdated and model does not consider the cholesterol uptake through LDL receptors pathway which is crucial for maximal steroid production. In fact Neither endogenous cellular cholesterol synthesis nor mobilization of stored cholesteryl esters is sufficient to support maximal steroid production, since hormone-stimulated steroid production is markedly augmented in the presence of lipoproteins [2].

Error fetching PMID 6326602:
Error fetching PMID 16985254:
  1. Error fetching PMID 6326602: [Dempsher_Gann_Phair_1984]
  2. Error fetching PMID 16985254: [Kraemer_others_2007]
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