Curriculum Vitae

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Curriculum Vitae of Qianben Wang Ph.D.

Curriculum Vitae Date prepared: June 16, 2010 Qianben Wang, Ph.D. Assistant Professor Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center College of Medicine Ohio State University

888 Biomedical Research Tower 460 West 12th Ave. Columbus, OH 43210 Phone: 614-247-1609 Fax: 614-688-4181 E-mail: Qianben.Wang@osumc.edu

EDUCATION Ph.D. 1998-2002 Physiology, University of Maryland School of Medicine, Baltimore, Maryland (Mentor: Joseph Fondell). B.Med 1989-1994 Clinical Medicine, Capital University of Medical Sciences, Beijing, China.

PROFESSIONAL POSITIONS Assistant Professor 2008- Department of Molecular and Cellular Biochemistry, Ohio State University College of Medicine, Ohio Instructor 2006-2008 Harvard Medical School, Dana-Farber Cancer Institute (Mentor: Myles Brown) Research Fellow 2003-2006 Dana-Farber Cancer Institute, Harvard Medical School (Mentor: Myles Brown) Postdoctoral Fellow 2002-2003 Department of Physiology and Biophysics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Jersey(Mentor: Joseph Fondell)

OTHER ACADEMIC POSITIONS HELD Member 2008- Comprehensive Cancer Center, Ohio State University Faculty member 2008- Ohio State Biochemistry Program (OSBP), Ohio State University Faculty member 2008- Molecular, Cellular and Developmental Biology (MCDB) Graduate Program, Ohio State University Faculty member 2008- Integrated Biomedical Science Graduate Program (IBGP), Ohio State University

PROFESSIONAL ACTIVITIES 1. Active member, The Endocrine Society 2. Active member, American Association for Cancer Research 3. Active member, The Society for Basic Urologic Research

RESEARCH FUNDING INFORMATION Ongoing Research Support 4R00 CA126160-04 07/01/09-06/30/12 NIH/NCI Genome-wide analysis of transcription factor function in prostate cancer Role: PI

3R00CA126160-04S1 08/01/09-07/31/10 NIH/NCI This award provides additional funding for 4R00CA126160-04 and is issued under the American Recovery and Reinvestment Act of 2009. Role: PI

2U54 CA113001-06 Huang (PI) 02/01/10-01/31/15 NIH/NCI Interrogating epigenetic changes in cancer genomes Role: Prostate Cancer Project Leader

PC094421 Li (PI) 09/30/10-09/30/13 DOD Integrative analysis of histone modifications and alternative splicing associated with aggressive prostate cancer Role: Consultant

Past Research Support 1K99CA126160-A1 08/22/07-6/30/09 NIH/NCI Genome-wide analysis of transcription factor function in prostate cancer Role: PI

Career Development Award in Prostate Cancer Research 04/01/06-4/1/07 Dana-Farber/Harvard Cancer Center SPORE in Prostate Cancer Genome-wide analysis of androgen receptor function in prostate cancer Role: PI

W81XWH-05-01-0023 11/01/04-11/30/06 Deparment of Defense postdoctoral traineeship award Allele-specific androgen receptor coregulator recruitment Role: PI

HONORS AND AWARDS 1. First Prize, Poster Presentation Award, Tri-institutional (Dana-Farber Cancer Institute/Johns Hopkins Medical Institute/Memorial Sloan-Kettering Cancer Center) Prostate Cancer Program Retreat, Rhode Island, 2008. 2. Travel Grant Award, The Endocrine Society, 2007. 3. Keystone Symposia Scholarship, National Institute of Diabetes, Digestive and Kidney Disease, National Institutes of Health, 2006. 4. Elected member, Honor Society of Phi kappa Phi, 2003. 5. Dr. Arthur Schwartz Award for Academic Advancement, University of Maryland, Baltimore, 2002.

AD HOC REVIEWER: • Cancer Research • Clinical Cancer Research • Current Molecular Medicine • Genes & Development • Journal of Cellular and Molecular Medicine • Molecular and Cellular Endocrinology • Oncogene • Trends in Endocrinology & Metabolism

TEACHING: IBGP 701.05 “Biology of Human Disease I”, Module 4 “ Transcriptional and Translation Control Mechanisms”, Ohio State University Integrated Biomedical Science Graduate Program course, Course lecturer for 29 gradutate students, 6 lectures, 1 hr/lecture, 2009 Autumn Quarter.

OSBP 796 “Interdisciplinary Seminar in Advanced Biochemistry”, Ohio State University Biochemistry Program course, Course Instructor for 26 graduate students, 2010 Winter Quarter.

CAMPUS/ACADEMIC SERVICES: • Judge, The 23rd Annual Edward F. Hayes Graduate Research Forum, Ohio State University, 2009 • Judge, Ohio State University Medical Center Research Day, 2009 • Graduate School Representative, Final Oral Examination for the Doctoral Degree (Ph.D. Candidate: Brian L. Bell), 2009 • Committee member (2009 ~) OSBP Seminar Committee • Committee member, Final Oral Examination for the Doctoral Degress (Ph.D. Candidate: Benjamin Rodriguez, IBGP), 2010 • Student Seminar Moderator (MCDB 800/890, 2010 winter quarter), MCDB graduate program • Judge, Ohio State University Medical Center Research Day, 2010 • Judge, Ohio State University Molecular Life Sciences Interdisciplinary Graduate Program Symposium, 2010 • Committee member, Dissertation Committee (Ph.D. student: Sankha Ghosh, MCDB) • Committee member, Advisory Committee (Ph.D. student, Mei Zhang, MCDB)

TRAINEES SUPERVISED: Advisor, Postdoctoral Fellows: Zhong Chen, M.D. 2008-present Chunpeng Zhang, Ph.D. 2008-present Dayong Wu, Ph.D. 2010-present Hongyan Chen, Ph.D. 2010-present Advisor, Ph.D. students: Yanping Shen, M.S. (OSBP) 2010-present Rotation Graduate Students Supervised: Zhenzhen Liu (OSBP, 2008) Brian Jan (MCDB, 2010) Yanping Shen (OSBP, 2010)

PUBLICATIONS

1. Hsu, P.Y., Hsu H.K., Singer G.A.C., Yan, P.S., Rodriguez B.A.T., Liu, J.C., Weng, Y.I., Deatherage, D.E., Pereira J.S., Lopez R., Russo J., Chen, Z., Wang, Q., Lamartiniere, C.A., Nephew, K.P., and Huang T. H.M. Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping. Genome Research, 20:733-744, 2010. 2. He H.H., Meyer, C.A., Shin, Y., Bailey, S., Wei, G., Wang, Q., Zhang, Y., Xu, K., Ni, M., Lupien, M., Mieczkowski, P., Lieb, J.D., Zhao, K., Brown, M., and Liu, X.S. Nucleosome dynamics defines transcriptional enhancers. Nature Genetics, 42:343-347, 2010. 3. Chen Z., Wang L., Wang Q.,* and Li W*. Histone modifications and chromatin organization in prostate cancer. Epigenomics, In press, 2010 (* Corresponding author). 4. Wang, Q.*#, Li, W#., Zhang, Y., Yuan X., Xu, K., Yu, J., Chen, Z., Beroukhim R, Wang, H., Wu, T., Lupien M., Carroll J.S., Manrai A.K., Jänne O.A., Balk S.P., Mehra R., Chinnaiyan A.M., Rubin M.A., True L., Fiorentino M., Fiore C., Loda, M., Kantoff P.W., Liu, X.S*., and Brown, M*. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell, 138:245-256, 2009. (*Corresponding author, # First author) (Featured Article) 5. Sun, T., Wang, Q., Balk, S.P., Brown M., Lee, G.S.M., and Kantoff P.W. Roles of microRNA-221 and -222 in castration resistant prostate cancer. Cancer Research, 69:3356-3363, 2009. 6. Nwachukwu, J.C, Mita, P., Ruoff, R., Ha, S., Wang , Q., Huang S. J., Taneja S.S., Brown, M., Gerald, W.L., Garabedian, M.J., and Logan, S.K. Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells. Cancer Research, 69:3140-3147, 2009. 7. Wang, Q. and Brown, M. Mapping the androgen receptor cistrome. In Tindall DJ and Mohler JL, eds. Androgen Action in Prostate Cancer, New York, NY: Springer Science and Business Media, pp.663-680, 2009. 8. Frigo, D.E., Sherk, A.B., Wittmann, B.M., Norris, J.D., Wang, Q., Joseph, J.D., Toner, A.P., Brown, M., and McDonnell, D.P. Androgen induce migration of prostate cancer cells by using the CXCR4 signaling axis through the expression of Krüppel-like factor 5. Molecular Endocrinology, 23:1385-1396, 2009. 9. Agoulnik, I.U., Bingman III, W.E., Nakka, M., Li, W., Wang, Q., Brown, M., Liu, X.S., and Weigel, N.L. Target gene specific regulation of androgen receptor activity by p42/p44 MAPK. Molecular Endocrinology, 22: 2420-2432, 2008. 10. Lupien, M., Eeckhoute, J., Meyer, C.A., Wang, Q., Zhang, Y., Carroll, J.S., Liu, X.S., and Brown, M. FoxA1 translates epigenetic signatures into lineage-specific transcription. Cell, 132:958-970, 2008. 11. Bao B.Y., Chuang B.F., Wang, Q., Kantoff P.W., Brown M., Sartor O., and Lee G.S.M. Regulation of UGT2B15/17 by androgen signaling in prostate cancer cells. Prostate, 68:839-848, 2008. 12. Wang, Q., Li, W., Liu, X.S., Carroll J.S., Jänne O.A., Keeton E.K., Chinnaiyan A.M., Pienta K.J. and Brown, M. A hierarchical network of transcription factors governs androgen receptor dependent prostate cancer growth. Molecular Cell, 27:380-392, 2007. (Featured Article) 13. Wang, Q.F., Prabhakar S, Wang, Q., Moses A.M., Chanan S., Brown M., Eisen M.B., Cheng J.F., Rubin E.M, and Boffelli D. Primate-specific evolution of an LDLR enhancer. Genome Biology, 7: R68, 2006. 14. Carroll J.S., Meyer C.A., Song J., Li W., Brodsky A.S., Geistlinger T.R., Eeckhoute J., Keeton E.K., Fertuck K.C., Hall G.F., Wang Q., Bekiranov S., Sementchenko V., Fox E.A., Silver P.A., Gingeras T.R., Liu X.S., and Brown M. Genome wide analysis of estrogen receptor binding sites. Nature Genetics, 38:1289-1297, 2006. 15. Wang, Q., Carroll J.S., and Brown, M. Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Molecular Cell, 19:631-642, 2005. 16. Wang, Q., Udayakumar T.S., Vasaitis T.S., Brodie A.H., and Fondell, J.D. Mechanistic relationship between androgen receptor polyglutamine tract truction and androgen-dependent transcriptional hyperactivity in prostate cancer cells. Journal of Biological Chemistry, 279:17319-17328, 2004. 17. Wang, H., Wang, Q., Srivastava, R.K., Gong, S.S., Lao, L., Fondell, J.D., and Wang, J.B. Effects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferation. Alternative Therapies in Health and Medicine, 9: 62-66, 2003. 18. Wang, Q., Dipali, S., Ren, Y., and Fondell, J.D. A coregulatory role for the TRAP-Mediator complex in androgen receptor-mediated gene expression. Journal of Biological Chemistry, 277:42852-42858, 2002. 19. Zhang, Y., Fondell, J.D., Wang, Q., Xia X., Cheng, A., Lu, M., and Hamburger, A.W. Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1. Oncogene, 21: 5609-5618, 2002. 20. Wang, Q. and Fondell, J.D. Generation of a mammalian cell line stably expressing a tetracycline-regulated epitope-tagged human androgen receptor: Implications for steroid hormone receptor research. Analytical Biochemistry, 289:217-230, 2001. 21. Ren,Y., Behre, E., Ren, Z., Zhang, J., Wang, Q., and Fondell, J.D. Specific structural motifs determine TRAP220 interactions with nuclear receptors. Molecular and Cellular Biology, 20: 5433-5446, 2000.

INVITED PRESENTATIONS 2009 Cincinnati Cancer Symposium Series-Jensen Symposium on Nuclear Receptors, selected short talks speaker, “H3K4 dimethylation orchestrates androgen receptor transcription complex binding in androgen-independent prostate cancer”, Cincinnati, Ohio.

2008 University of Chicago invited speaker, “Transcriptional regulation by androgen receptor in prostate cancer: From single gene to whole genome.” Chicago, Illinois.

2007 Ohio State University (Columbus, Ohio), Peking Union Medical College (Beijing, China), China-Japan Friendship Hospital (Beijing China), University of Alabama (Birmingham, Alabama), Massachusetts General Hospital (Boston, Massachusetts), University of Michigan (An Arbor, Michigan), Indiana University (Bloomington, Indiana) invited speaker, “Transcriptional regulation by androgen receptor: From single gene to whole genome.”

2007 89th Endocrine Society Annual Meeting, selected speaker, “Genome-wide analysis of androgen receptor function in prostate cancer cells.” Toronto, Canada.

2006 Endopäivät 2006-Annual Meeting of the Finnish Endocrine Society, invited speaker, “Non-canonical responsive elements and multiple collaborating transcription factors are required for androgen-dependent transcription.” Helsinki, Finland.

2006 The 1st Harvard Cistrome (cis-acting targets of a trans-acting factor on a genome scale) meeting, invited speaker, “Non-canonical responsive elements and multiple collaborating transcription factors are required for androgen-dependent transcription.” Boston, Massachusetts.

2001 China-Japan Friendship Institute of Medical Sciences Seminar, invited speaker “Regulation of androgen receptor mediated gene transcription.” Beijing, China.

2001 4th Maryland-Johns Hopkins Annual Retreat on Reproductive Biology, selected speaker, “Generation of a mammalian cell line stably expressing a tetracycline-regulated epitope-tagged human androgen receptor: Implications for prostate cancer research.” Oella, Maryland.

2000 Center for Studies in Reproduction Research Forum, University of Maryland School of Medicine, invited speaker, “Generation of a stable cell line stably expressing an epitope-tagged androgen receptor: Implications for androgen receptor research.” Baltimore, Maryland.

POSTER PRESENTATIONS

2009 National Cancer Institute Integrative Cancer Biology Program (ICBP) Steering Committee Meeting, “Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer” (Wang, Q.*#, Li, W#., Zhang, Y., Yuan X., Xu, K., Yu, J., Chen, Z., Beroukhim R, Wang, H., Wu, T., Lupien M., Carroll J.S., Manrai A.K., Jänne O.A., Balk S.P., Mehra R., Chinnaiyan A.M., Rubin M.A., True L., Fiorentino M., Fiore C., Loda, M., Kantoff P.W., Liu, X.S*., and Brown, M*.) Palo Alto, California, June 29-30, 2009.