Dahlquist:Yeast Transcription Factors

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(TF Network Data: added another paper)
(TF Network Data: link to MacIsaac data file)
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[http://fraenkel.mit.edu/improved_map/ Supplementary Data Web Site]
[http://fraenkel.mit.edu/improved_map/ Supplementary Data Web Site]
[[Media:MacIsaac_BMCBioinformatics_06_SuppData_orfs_by_factor.zip | Supplementary Data in zipped .xls file]]
#Paper4 pmid=16709784
#Paper4 pmid=16709784
//TF-target interactions in DNA damage response
//TF-target interactions in DNA damage response

Revision as of 17:57, 24 June 2010

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Dahlquist Lab Yeast Transcription Factor Resources

This page displays a compiled list of yeast transcription factor resources. Included are data on transcription factor target genes and transcription factor regulatory networks in yeast, links to web servers providing easy-to-use TF searches and other potentially helpful resources.

TF Network Data

Error fetching PMID 12399584:
Error fetching PMID 15343339:
Error fetching PMID 16522208:
Error fetching PMID 16709784:
Error fetching PMID 17417638:
Error fetching PMID 19690563:
Error fetching PMID 16762362:
Error fetching PMID 14555958:
Error fetching PMID 17224918:
Error fetching PMID 19158363:
Error fetching PMID 16551355:
  1. Error fetching PMID 12399584: [Paper1]
  2. Error fetching PMID 15343339: [Paper2]
  3. Error fetching PMID 16522208: [Paper3]
    Updated TF network to determine new relationships

    Used improved algorithms to detect new regulatory relationships in the transcription factor network

    Fig. 3 Shows that the effect on Cin5 was to gain approximately 10 new interactions and lose approximately two as compared to the older model. A figure of the new network was downloaded. PDF format

    Supplementary Data Web Site

    Supplementary Data in zipped .xls file

  4. Error fetching PMID 16709784: [Paper4]
    TF-target interactions in DNA damage response

    Measured binding locations(ChIP-chip) of damage-related transcription factors (including Cin5) after exposure to MMS. Validated by checking against binding in knock-out strains for TFs.

    Downloaded the MMS and Untreated ChIP datasets to be filtered for Cin5p targets, Excel spreadsheet of p values for binding.

  5. Error fetching PMID 17417638: [Paper5]
    TF network discovered through systematic deletions

    Performed microarray analysis of knockout strains for many transcription factors and compared expression profiles to determine regulatory relationships. Allows distinguishing between activated and repressed transcription factor targets

    Downloaded the filtered and unfiltered network in X-score format. Gene-gene-value triples.

  6. Error fetching PMID 19690563: [Paper6]
  7. Error fetching PMID 16762362: [Paper7]
    Full text from ScienceDirect

  8. Error fetching PMID 14555958: [Paper8]
    Abstract and Supplemental Data

  9. Error fetching PMID 17224918: [Paper9]
    Cold Shock Temporal Network Data

    Used new algoithm to construct temporal networks of yeast's response to various stresses, including cold shock. For cold shock data, the paper analyzes data from the Gasch, et al. (2000) paper. Supplementary data has cold shock temporal response, but does not show any interactions between transcription factors and targets. (Note: the Gasch et al. paper does not have a true "cold shock" response. They only measure the effect of a temperature downshift from 37°C to 25°C. Cold shock is defined in the range of 10°C to 18°C

  10. Error fetching PMID 19158363: [Paper10]
  11. Error fetching PMID 16551355: [Paper11]
All Medline abstracts: PubMed HubMed

Web Servers

  • MYBS Mining Yeast Binding Sites
    • The search regulatory associations function allows the user to input a list of genes of interest and search for candidate transcription factors that regulate the list of genes. Allows filtering according to multiple criteria.
    • From Tsai, HK, et al. MYBS: A comprehensive web server for mining transcription factor binding sites in yeast. Nucleic Acids Research 2007. PubMed
  • TFSVM Transcription Factor Support Vector Machine
    • Allows user to input either a single transcription factor to get a list of regulated target genes or a single gene to get a list of transcription factors that regulate that gene. Can also filter according to a threshold value
    • Downloaded the list of Cin5p targets with a threshold value >0.997.
    • From Holloway, DT, et al. Classifying transcription factor targets and discovering relevant biological features. Biology Direct 2008. 3:22. PubMed
  • YEASTRACT Yeast Search for Transcriptional Regulators and Consensus Tracking
    • Multiple tools are provided on this server. Those of interest include a search for regulatory relationships either by transcription factor or by target gene. Applies a different algorithm to find new regulatory relationships in previously published data from Lee, Harbison, Tan and Workman
    • Downloaded list of documented Cin5p targets.
    • From Monteiro, PT, et al. YEASTRACT-DISCOVERER: new tools to improve analysis of transcriptional regulatory associations in Saccharomyces cerevisiae. Nucleic Acids Research 2008. PubMed
  • ChIPCodis Mining of Regulatory Transcription Factor Data in Yeast
    • Allows the user to input a list of genes and provides list of candidate transcription factors that regulate. References either Harbison or MacIsaac data.
    • From Abascal, F et al. ChIPCodis: mining complex regulatory systems in yeast by concurrent enrichment analysis of chip-on-chip data. Bioinformatics 2008. PubMed
  • List of Yeast Transcription Factors (don't know when this web page was updated)
  • Jaspar TF binding site motif database
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