Das Lab:Publications

Selected Publications Gemini, a bifunctional enzymatic and fluorescent reporter of gene expression
PLoS ONE 4(11): e7569. doi:10.1371/journal.pone.0007569
Lance Martin, Austin Che, Drew Endy
URL PDF reprint

Dramatic reduction of dimensionality in large biochemical networks owing to strong pair correlations
Journal of the Royal Society Interface (2012) [PubMed]
Michael Dworkin, Sayak Mukherjee, Ciriyam Jayaprakash and Jayajit Das

1. Matthew J. Riese, Jashanpreet Grewal, Jayajit Das, Vineet Patil, Arup K. Chakraborty, and Gary Koretzky, "Decreased DAG Metabolism Enhances Erk Activation and Augments CD8+ T cell Function Responses", Journal of Biological Chemistry 286, 5254 (2011).

Jayajit Das, "Activation or Tolerance of Natural Killer Cells is Modulated by Ligand Quality in a Non-Monotonic Manner", Biophysical Journal 99, 2028 (2010). Arup Chakraborty, Jayajit Das. Pairing computation with experiments: a powerful coupling for understanding T cell signaling. Nature Reviews Immunology 10, 59 (2010). PubMed ID: 20029448

1. Jayajit Das, Jean M Frechet, Arup Chakraborty. Self-Assembly of Dendronized Polymers. Journal of Physical Chemistry B 113, 13768 (2009) PubMed ID: 19572661

1. Jayajit Das, Mehran Kardar, Arup Chakraborty. Positive feedback regulation results in spatial clustering and fast spreading of active signaling molecules on a cell membrane. Journal of Chemical Physics 130 ,245102 (2009). PubMed ID: 19566183

Arup Chakraborty, Jayajit Das, Julie Zikherman, Ming Yang, Christopher Govern, Mary Ho, Arthur Weiss, and Jeroen Roose. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Science Signaling 2, pt2 (2009). doi: 10. 1126/scisignal.266pt2 PubMed ID: 19366993

1. Jayajit Das, Mary Ho, Julie Zikherman, Christopher Govern, Ming Yang, Arthur Weiss, Arup Chakraborty, and Jeroen Roose. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell 136, 337-51 (2009).doi: 10. 1016/j.cell.2008.11.051 PubMed ID: 19167334

Ashok Prasad A. Julie Zikherman J, Jayajit Das, Jeroen Roose, Arthur Weiss, and Arup Chakraborty. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. PNAS 106, 528-33 (2009). doi: 10. 1073/pnas.0805981105 PubMed ID: 19098101

1. S. Cemerski, Jayajit Das, Emanuele Giurisato, Mary A. Markiewicz, Paul M. Allen, Arup K. Chakraborty and Andrey S. Shaw, "Evidence for signaling from the center of the immune synapse" Immunity 29, 414-22 (2008).

This paper is in the Editors Choice of Science Signaling (Issue 23rd September 2008.) Also see a preview of this paper by S. Valitutti in the same issue of Immunity. PubMed ID: 18760640

1. Maxim Artyomov, Jayajit Das, Mehran Kardar and Arup K. Chakraborty. "Purely stochastic binary decision in cell signaling models without underlying deterministic bistabilities" PNAS 104, 18958-18963 (2007). Special mention in Physics Today 61, 28(2008) PubMed ID: 18025473

1. Dennis Wylie, Jayajit Das and Arup K. Chakraborty. "Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module" PNAS 104, 5533-5538 (2007). This paper is selected in the faculty of 1000 Biology papers PubMed ID: 17360359

1. S. Cemerski*, Jayajit Das*, Jason Locasale, Pheobe Arnold, Emanuele Giurisato, Mary A. Markiewicz, Daved Fremont, Paul M. Allen, Arup K. Chakraborty and Andrey S. Shaw, "The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse" Immunity 26, 345-55 ( 2007). *These authors have equal contribution PubMed ID: 17346997