Das Lab:Research: Difference between revisions
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[[Systems Immunology | '''Systems Immunology''']] <br> | [[Systems Immunology | '''Systems Immunology''']] <br> | ||
We seek a systems level understanding of immune responses in metazoans using a combination of mechanistic and data driven in silico modeling with experiments.<br> | We seek a systems level understanding of immune responses in metazoans using a combination of mechanistic and data driven in silico modeling with experiments.<br> | ||
#[[Jayajit Das]], '''Activation or Tolerance of Natural Killer Cells is Modulated by Ligand Quality in a Non-Monotonic Manner''', ''Biophysical Journal'' (2010) [[http://www.ncbi.nlm.nih.gov/pubmed/20923636 PubMed]]. <br> | |||
#Sayak Mukherjee et al., '''Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases''', '' Science Signaling'' (2013) [[http://www.ncbi.nlm.nih.gov/pubmed/23281368 PubMed]] <br> | |||
[[Mechanistic Data Driven Models | '''Mechanistic Data Driven Models''']] <br> | [[Mechanistic Data Driven Models | '''Mechanistic Data Driven Models''']] <br> | ||
Can we decipher mechanisms from data driven models of cell signaling? <br> | Can we decipher mechanisms from data driven models of cell signaling? <br> | ||
#Michael Dworkin et al., '''Dramatic reduction of dimensionality in large biochemical networks owing to strong pair correlations''', ''Journal of the Royal Society Interface'' (2012) [[http://www.ncbi.nlm.nih.gov/pubmed/22378749 PubMed]] <br> | |||
[[Stochastic Processes | '''Stochastic Processes in Cell Signaling Networks''']] <br> | [[Stochastic Processes | '''Stochastic Processes in Cell Signaling Networks''']] <br> | ||
We aim to uncover basic principles that underlie stochastic noise fluctuations in cell signaling by analyzing minimal models. <br> | We aim to uncover basic principles that underlie stochastic noise fluctuations in cell signaling by analyzing minimal models. <br> | ||
#[[Jayajit Das]], '''Positive feedback produces broad distributions in maximum activation attained within a narrow time window in stochastic biochemical reactions''', '' Journal of Chemical Physics'' (2013) [[http://www.ncbi.nlm.nih.gov/pubmed/23298061 PubMed]] <br> | |||
Revision as of 11:48, 31 January 2013
Systems Immunology
We seek a systems level understanding of immune responses in metazoans using a combination of mechanistic and data driven in silico modeling with experiments.
- Jayajit Das, Activation or Tolerance of Natural Killer Cells is Modulated by Ligand Quality in a Non-Monotonic Manner, Biophysical Journal (2010) [PubMed].
- Sayak Mukherjee et al., Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases, Science Signaling (2013) [PubMed]
Mechanistic Data Driven Models
Can we decipher mechanisms from data driven models of cell signaling?
- Michael Dworkin et al., Dramatic reduction of dimensionality in large biochemical networks owing to strong pair correlations, Journal of the Royal Society Interface (2012) [PubMed]
Stochastic Processes in Cell Signaling Networks
We aim to uncover basic principles that underlie stochastic noise fluctuations in cell signaling by analyzing minimal models.
- Jayajit Das, Positive feedback produces broad distributions in maximum activation attained within a narrow time window in stochastic biochemical reactions, Journal of Chemical Physics (2013) [PubMed]
