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==Personal Info==


=Personal Info=
[[Image:DGM-pic.JPG|350 px|left|David G. Míguez]]
''Current position:'' posdoctoral fellow at Silver lab. Systems Biology department, Harvard Medical School.


''Background:'' Nonlinear Dynamics, reaction-diffusion, autocatalitic and bistable systems, feedback, pH oscillators, Turing Patterns, Enzyme kinetics.
Head of the [http://sysbio.openwetware.org/  Biophysics and Systems Biology Lab  ]


''Interest:'' Systems biology and signal transduction pathways in mammalian cells.
Departamento de Física de la Materia Condensada, Universidad Autónoma de Madrid, 28049 Madrid


=Contact=


David G. Míguez
''Previous Research Institutions'': 
 
*2001-2005 PhD Thesis at Group of Nonlinear Physics at Santiago de Compostela (Galicia, Spain),
 
*2005-2006 Group of Complex Systems, Brandeis University (MA)


e-mail: david_miguez ''AT''  hms DOT harvard DOT edu
*2006-2009 Department of Systems Biology, Harvard Medical School (MA),


Personal Web: http://silver.med.harvard.edu/david/
*2009-2011 Instituto de Biología Molecular de Barcelona (CSIC, Spain)


Blog: http://web.mac.com/miguez
''Background:'' Nonlinear Dynamics, reaction-diffusion, autocatalitic and bistable systems, feedback, pH oscillators, Turing Patterns, Enzyme kinetics, Systems Biology in Cancer, Signaling pathways.  


Systems Biology
''Interests:'' Systems Biology, Biophysics, Developmental Systems Biology


Harvard Medical School
Editor of [http://www.iospress.nl/journal/in-silico-biology/ In Silico Biology]


200 Longwood Ave, Alpert 536
==Contact==


Boston, MA 02115
David G. Míguez


Phone:(+01) 617 432 6406
e-mail: david DOT miguez  ''AT'' uam DOT es


Cell phone: (+01) 617 777 3264
Depto. de Fisica de la Materia Condensada
Facultad de Ciencias, Mod 8, 4-13
Universidad Autonoma de Madrid
Cantoblanco,
28049 Madrid (SPAIN)


Fax: 617-432-5012
phone (+34) 717-711-470
work  (+34) 914-978-076


=Publications=
==Publications==
# S. Alonso, D.G. Míguez, F. Sagués, “Differential susceptibility to noise of mixed Turing and Hopf modes in a photosensitive chemical medium”, Europhys. Lett, '''in Press''' (2008).  
# A. Valencia-Expósito*, I. Grosheva*, D. G. Míguez*, A. González-Reyes, M. D. Martín-Bermudo, ''[http://www.nature.com/ncomms/2016/160218/ncomms10746/full/ncomms10746.html The Myosin Light Chain Phosphatase is required in epithelial cells to control basal actomyosin oscillations governing tissue elongation]'', Nature Communications '''7''', 10746 (2016) (*shared 1st authorship)
# D.G. Míguez, V. K. Vanag, I. R. Epstein, “Fronts and pulses in an enzymatic reaction with glucose oxidase" P.N.A.S. '''104''', 6992 (2007).
# D. G. Míguez, ''[http://www.nature.com/articles/srep13265 A Branching Process to Characterize the Dynamics of Stem Cell Differentiation]'', Scientific Reports '''5''', 13265 (2015)
# V. K. Vanag, D.G. Míguez, I. R. Epstein, “Designing an Enzymatic Oscillator: Bistability and Feedback Control led Oscillations with Glucose Oxidase in a CSTR”, J. Phys. Chem. '''125''', 194515 (2006).
#  V. Doldán-Martelli & D. G. Míguez, ''[http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117558 Synergistic Interaction between Selective Drugs in Cell Populations Models], PloS one '''10''' (2), e0117558 (2015).
# D.G. Míguez, S. Alonso, A.P. Muñuzuri, F. Sagués, “Turing patterns of oscillating spots”, Phys. Rev. Lett, '''97''', 178301 (2006).  
# A. L. Sanz & D. G. Míguez, ''[http://www.landesbioscience.com/journals/neurogenesis/article/29529/ Dual R-Smads interplay in the regulation of vertebrate neurogenesis]''.  Neurogenesis '''1''', e29529 (2014).
# D. G. Míguez, A. P. Muñuzuri,“On the orientation of stripes in fish skin patterning”, Biophys. Chem. '''124''', 161 (2006).  
# T. Ruiz-Herrero, J. Estrada, R. Guantes, D. G. Miguez, ''[http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003274 A tunable coarse-grained model for ligand-receptor interaction]'', PLOS Computational Biology  '''9''', e1003274.(2013).
# D. G. Míguez, R. A. Satnoianu, A. P. Muñuzuri, "Experimental steady pattern formation in reaction-diffusion-advection systems", Phys. Rev. E '''73''', 025201 (R) (2006).
# D. G. Míguez*, E. Gil-Guiñón, S. Pons and E. Martí ''[http://jcs.biologists.org/content/early/2013/10/08/jcs.130435.abstract Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis]'', Journal Of Cell Science '''126''', 5335 (2013). '''(*First and corresponding authorship)'''
# D. G. Míguez, M. Dolnik, A. P. Muñuzuri, L. Kramer, "Effect of Axial Growth on Turing Pattern Formation".  Phys. Rev. Lett '''96''', 048304 (2006).
#  M. Saade, I. Gutiérrez-Vallejo, G. Le Dréau, M. A. Rabadán, D. G. Miguez, J. Buceta, E. Martí  ''[http://www.sciencedirect.com/science/article/pii/S2211124713003306 Sonic hedgehog signaling switches the mode of division in the developing nervous system]'', Cell Reports '''4''',492 (2013).
# D. G. Míguez, G. Izús, A. P. Muñuzuri, "Robustness and Stability of Flow-and-Diffusion Structures", Phys. Rev. E '''73''', 016207 (2006).
#  D. G. Míguez,  ''[http://link.springer.com/article/10.1007%2Fs12539-013-0165-x Network Nonlinearities in Drug Treatment]'', Interdisciplinary Sciences: Computational Life Sciences 5,85 (2013).
# D. G. Miguez, V. Perez-Villar, and A. P. Munuzuri, "Turing instability controlled by spatiotemporal imposed dynamics", Phys. Rev. E '''71''', 066217 (2005).
#  P. Gregorio-Godoy, D. G. Míguez, ''[http://digital-library.theiet.org/content/journals/10.1049/iet-syb.2012.0026 Synthetic approaches to study transcriptional networks and noise in mammalian systems]'', IET Systems Biology 7,11 (2013).
# F. Sagués, D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, L. Kramer, "Spatio-Temporal Forcing of Turing Patterns", Physica D '''199''', 235 (2004) .
# V. Doldán-Martelli, R. Guantes, D. G. Míguez, ''[http://www.nature.com/psp/journal/v2/n2/full/psp20132a.html  A Mathematical Model for the Rational Design of Chimeric Ligands in Selective Drug Therapies]'', CPT: Pharmacometrics & Systems Pharmacology '''2''', e26 (2013).
# D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, F. Sagués, L. Kramer, "Traveling-Stripe Forcing Generates Hexagonal Patterns", Phys. Rev. Lett. '''93''', 048303 (2004) .
# V. Doldán-Martelli, D. G. Míguez, ''Theoretical Approaches to Growth Hormone Signaling'', in 'Growth Hormones: Synthesis, Regulation and Health Implications', Eds. A. Andersdtr and J.  Anderssen Nova Publishers ISBN 9781619426818 (2012).
# M. Kærn, D. G. Míguez, A. P. Muñuzuri, M. Menzinger, "Control of chemical pattern formation by a clock-and-wavefront type mechanism", Biophys. Chem. '''110''', 231 (2004). '''Shared 1st authorship'''.
# D. G. Míguez, Milos Dolnik, Irving Epstein and Alberto P. Muñuzuri, ''[http://pre.aps.org/abstract/PRE/v84/i4/e046210 Interaction Of Chemical Patterns in Coupled Layers]'', Phys. Rev. E, '''84''', 046210 (2011).
# B. Peña, C. Pérez-García, A. Sanz-Anchelergues, "Transverse instabilities in chemical Turing patterns of stripes", D. G. Míguez, A. P. Muñuzuri, Phys. Rev. E '''68''', 056206 (2003) .
# D. G. Míguez, ''[http://www.sciencedirect.com/science/article/pii/S0301462210000402 The role of asymmetric binding in ligand-receptor systems with 1:2 interaction ratio]''  Biophys Chem '''148''', 74-81 (2010)
# S. Rüdiger, D. G. Míguez, A. P. Muñuzuri, F. Sagués, J. Casademunt, "Dynamics of Turing Patterns under Spatiotemporal Forcing", Phys. Rev. Lett '''90''', 128301 (2003).
# D.G. Míguez, ''Forcing of Nonlinear Pattern Formation Systems'',  Lambert Academic Publishing, ISBN 9783838364223 (2010) [http://www.amazon.com/Forcing-Nonlinear-Pattern-Formation-Systems/dp/3838364228 Book].
# D. G. Míguez, P. McGraw, A. P. Muñuzuri and M. Menzinger, ''[http://pre.aps.org/abstract/PRE/v80/i2/e026208 Selection of Flow-Distributed Oscillation and Turing Patterns by Boundary Forcing in a Linearly Growing, Oscillating Medium]'', Phys. Rev. E, '''80''', 026208 (2009).
# I. A. Swinburne, D. G. Míguez, D. Landgraf, and P. A. Silver, ''[http://genesdev.cshlp.org/content/22/17/2342.full Intron length increases oscillatory periods of gene expression in animal cells]'', Genes & Dev., '''22''' 2008, 2342-2346 (2008).
# S. Alonso, D. G. Míguez, F. Sagués, ''[http://iopscience.iop.org/0295-5075/81/3/30006 Differential susceptibility to noise of mixed Turing and Hopf modes in a photosensitive chemical medium]'', Europhys. Lett, '''81''', 30006 (2008).  
# D. G. Míguez, V. K. Vanag, I. R. Epstein, ''[http://www.pnas.org/content/104/17/6992.full Fronts and pulses in an enzymatic reaction with glucose oxidase]'' P.N.A.S. '''104''', 6992 (2007).
# V. K. Vanag, D.G. Míguez, I. R. Epstein, ''[http://jcp.aip.org/resource/1/jcpsa6/v125/i19/p194515_s1 Designing an Enzymatic Oscillator: Bistability and Feedback Control led Oscillations with Glucose Oxidase in a CSTR]'', J. Phys. Chem. '''125''', 194515 (2006).
# D.G. Míguez, S. Alonso, A.P. Muñuzuri, F. Sagués, ''[http://prl.aps.org/abstract/PRL/v97/i17/e178301 Experimental evidence of localized oscillations in the photosensitive chlorine dioxide-iodine-malonic acid reaction]'', Phys. Rev. Lett, '''97''', 178301 (2006).  
# D. G. Míguez, A. P. Muñuzuri, ''[http://www.sciencedirect.com/science/article/pii/S0301462206002122 On the orientation of stripes in fish skin patterning]'', Biophys. Chem. '''124''', 161 (2006).  
# D. G. Míguez, R. A. Satnoianu, A. P. Muñuzuri, ''[http://pre.aps.org/abstract/PRE/v73/i2/e025201 Experimental steady pattern formation in reaction-diffusion-advection systems]'', Phys. Rev. E '''73''', 025201 (R) (2006).
# D. G. Míguez, M. Dolnik, A. P. Muñuzuri, L. Kramer, ''[http://prl.aps.org/abstract/PRL/v96/i4/e048304 Effect of Axial Growth on Turing Pattern Formation]''.  Phys. Rev. Lett '''96''', 048304 (2006).
# D. G. Míguez, G. Izús, A. P. Muñuzuri, ''[http://pre.aps.org/abstract/PRE/v73/i1/e016207 Robustness and Stability of Flow-and-Diffusion Structures]'', Phys. Rev. E '''73''', 016207 (2006).
# D. G. Miguez, V. Perez-Villar, and A. P. Munuzuri, ''[http://pre.aps.org/abstract/PRE/v71/i6/e066217 Turing instability controlled by spatiotemporal imposed dynamics]'', Phys. Rev. E '''71''', 066217 (2005).
# F. Sagués, D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, L. Kramer, ''[http://www.sciencedirect.com/science/article/pii/S0167278904003197 Travelling-stripe forcing of Turing patterns]'', Physica D '''199''', 235 (2004).
# D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, F. Sagués, L. Kramer, ''[http://prl.aps.org/abstract/PRL/v93/i4/e048303 Traveling-Stripe Forcing Generates Hexagonal Patterns]'', Phys. Rev. Lett. '''93''', 048303 (2004).
# M. Kærn*, D. G. Míguez*, A. P. Muñuzuri, M. Menzinger, ''[http://www.sciencedirect.com/science/article/pii/S030146220400078X Control of chemical pattern formation by a clock-and-wavefront type mechanism]'', Biophys. Chem. '''110''', 231 (2004). '''*Shared 1st authorship'''.
# B. Peña, C. Pérez-García, A. Sanz-Anchelergues, D. G. Míguez, A. P. Muñuzuri, ''[http://pre.aps.org/abstract/PRE/v68/i5/e056206 Transverse instabilities in chemical Turing patterns of stripes]'',  Phys. Rev. E '''68''', 056206 (2003).
# S. Rüdiger, D. G. Míguez, A. P. Muñuzuri, F. Sagués, J. Casademunt, ''[http://prl.aps.org/abstract/PRL/v90/i12/e128301 Dynamics of Turing Patterns under Spatiotemporal Forcing]'', Phys. Rev. Lett '''90''', 128301 (2003).


Updated by: [[User:DavidMiguez|David]] 11:01, 3 December 2007 (CST)
*'''[[User:DavidMiguez|David]] 08:26, 1 September 2015 (EDT)'''

Revision as of 03:03, 19 February 2016

Personal Info

David G. Míguez
David G. Míguez

Head of the Biophysics and Systems Biology Lab

Departamento de Física de la Materia Condensada, Universidad Autónoma de Madrid, 28049 Madrid


Previous Research Institutions:

  • 2001-2005 PhD Thesis at Group of Nonlinear Physics at Santiago de Compostela (Galicia, Spain),
  • 2005-2006 Group of Complex Systems, Brandeis University (MA)
  • 2006-2009 Department of Systems Biology, Harvard Medical School (MA),
  • 2009-2011 Instituto de Biología Molecular de Barcelona (CSIC, Spain)

Background: Nonlinear Dynamics, reaction-diffusion, autocatalitic and bistable systems, feedback, pH oscillators, Turing Patterns, Enzyme kinetics, Systems Biology in Cancer, Signaling pathways.

Interests: Systems Biology, Biophysics, Developmental Systems Biology

Editor of In Silico Biology

Contact

David G. Míguez

e-mail: david DOT miguez AT uam DOT es

Depto. de Fisica de la Materia Condensada Facultad de Ciencias, Mod 8, 4-13 Universidad Autonoma de Madrid Cantoblanco, 28049 Madrid (SPAIN)

phone (+34) 717-711-470 work (+34) 914-978-076

Publications

  1. A. Valencia-Expósito*, I. Grosheva*, D. G. Míguez*, A. González-Reyes, M. D. Martín-Bermudo, The Myosin Light Chain Phosphatase is required in epithelial cells to control basal actomyosin oscillations governing tissue elongation, Nature Communications 7, 10746 (2016) (*shared 1st authorship)
  2. D. G. Míguez, A Branching Process to Characterize the Dynamics of Stem Cell Differentiation, Scientific Reports 5, 13265 (2015)
  3. V. Doldán-Martelli & D. G. Míguez, Synergistic Interaction between Selective Drugs in Cell Populations Models, PloS one 10 (2), e0117558 (2015).
  4. A. L. Sanz & D. G. Míguez, Dual R-Smads interplay in the regulation of vertebrate neurogenesis. Neurogenesis 1, e29529 (2014).
  5. T. Ruiz-Herrero, J. Estrada, R. Guantes, D. G. Miguez, A tunable coarse-grained model for ligand-receptor interaction, PLOS Computational Biology 9, e1003274.(2013).
  6. D. G. Míguez*, E. Gil-Guiñón, S. Pons and E. Martí Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis, Journal Of Cell Science 126, 5335 (2013). (*First and corresponding authorship)
  7. M. Saade, I. Gutiérrez-Vallejo, G. Le Dréau, M. A. Rabadán, D. G. Miguez, J. Buceta, E. Martí Sonic hedgehog signaling switches the mode of division in the developing nervous system, Cell Reports 4,492 (2013).
  8. D. G. Míguez, Network Nonlinearities in Drug Treatment, Interdisciplinary Sciences: Computational Life Sciences 5,85 (2013).
  9. P. Gregorio-Godoy, D. G. Míguez, Synthetic approaches to study transcriptional networks and noise in mammalian systems, IET Systems Biology 7,11 (2013).
  10. V. Doldán-Martelli, R. Guantes, D. G. Míguez, A Mathematical Model for the Rational Design of Chimeric Ligands in Selective Drug Therapies, CPT: Pharmacometrics & Systems Pharmacology 2, e26 (2013).
  11. V. Doldán-Martelli, D. G. Míguez, Theoretical Approaches to Growth Hormone Signaling, in 'Growth Hormones: Synthesis, Regulation and Health Implications', Eds. A. Andersdtr and J. Anderssen Nova Publishers ISBN 9781619426818 (2012).
  12. D. G. Míguez, Milos Dolnik, Irving Epstein and Alberto P. Muñuzuri, Interaction Of Chemical Patterns in Coupled Layers, Phys. Rev. E, 84, 046210 (2011).
  13. D. G. Míguez, The role of asymmetric binding in ligand-receptor systems with 1:2 interaction ratio Biophys Chem 148, 74-81 (2010)
  14. D.G. Míguez, Forcing of Nonlinear Pattern Formation Systems, Lambert Academic Publishing, ISBN 9783838364223 (2010) Book.
  15. D. G. Míguez, P. McGraw, A. P. Muñuzuri and M. Menzinger, Selection of Flow-Distributed Oscillation and Turing Patterns by Boundary Forcing in a Linearly Growing, Oscillating Medium, Phys. Rev. E, 80, 026208 (2009).
  16. I. A. Swinburne, D. G. Míguez, D. Landgraf, and P. A. Silver, Intron length increases oscillatory periods of gene expression in animal cells, Genes & Dev., 22 2008, 2342-2346 (2008).
  17. S. Alonso, D. G. Míguez, F. Sagués, Differential susceptibility to noise of mixed Turing and Hopf modes in a photosensitive chemical medium, Europhys. Lett, 81, 30006 (2008).
  18. D. G. Míguez, V. K. Vanag, I. R. Epstein, Fronts and pulses in an enzymatic reaction with glucose oxidase P.N.A.S. 104, 6992 (2007).
  19. V. K. Vanag, D.G. Míguez, I. R. Epstein, Designing an Enzymatic Oscillator: Bistability and Feedback Control led Oscillations with Glucose Oxidase in a CSTR, J. Phys. Chem. 125, 194515 (2006).
  20. D.G. Míguez, S. Alonso, A.P. Muñuzuri, F. Sagués, Experimental evidence of localized oscillations in the photosensitive chlorine dioxide-iodine-malonic acid reaction, Phys. Rev. Lett, 97, 178301 (2006).
  21. D. G. Míguez, A. P. Muñuzuri, On the orientation of stripes in fish skin patterning, Biophys. Chem. 124, 161 (2006).
  22. D. G. Míguez, R. A. Satnoianu, A. P. Muñuzuri, Experimental steady pattern formation in reaction-diffusion-advection systems, Phys. Rev. E 73, 025201 (R) (2006).
  23. D. G. Míguez, M. Dolnik, A. P. Muñuzuri, L. Kramer, Effect of Axial Growth on Turing Pattern Formation. Phys. Rev. Lett 96, 048304 (2006).
  24. D. G. Míguez, G. Izús, A. P. Muñuzuri, Robustness and Stability of Flow-and-Diffusion Structures, Phys. Rev. E 73, 016207 (2006).
  25. D. G. Miguez, V. Perez-Villar, and A. P. Munuzuri, Turing instability controlled by spatiotemporal imposed dynamics, Phys. Rev. E 71, 066217 (2005).
  26. F. Sagués, D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, L. Kramer, Travelling-stripe forcing of Turing patterns, Physica D 199, 235 (2004).
  27. D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, F. Sagués, L. Kramer, Traveling-Stripe Forcing Generates Hexagonal Patterns, Phys. Rev. Lett. 93, 048303 (2004).
  28. M. Kærn*, D. G. Míguez*, A. P. Muñuzuri, M. Menzinger, Control of chemical pattern formation by a clock-and-wavefront type mechanism, Biophys. Chem. 110, 231 (2004). *Shared 1st authorship.
  29. B. Peña, C. Pérez-García, A. Sanz-Anchelergues, D. G. Míguez, A. P. Muñuzuri, Transverse instabilities in chemical Turing patterns of stripes, Phys. Rev. E 68, 056206 (2003).
  30. S. Rüdiger, D. G. Míguez, A. P. Muñuzuri, F. Sagués, J. Casademunt, Dynamics of Turing Patterns under Spatiotemporal Forcing, Phys. Rev. Lett 90, 128301 (2003).
  • David 08:26, 1 September 2015 (EDT)
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