De la Cruz:Research - Revision history

Fernando at 01:40, 12 February 2011

Fernando — Sat, 12 Feb 2011 01:40:13 GMT

←Older revision		Revision as of 01:40, 12 February 2011
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	Back to main page[[http://openwetware.org/wiki/De_la_Cruz_Lab]]		Back to main page[[http://openwetware.org/wiki/De_la_Cruz_Lab]]
-	http://grupos.unican.es/intergenomica/	+
		+	http://grupos.unican.es/intergenomica/research.htm

	[[Image:cuatrologos.jpg]]		[[Image:cuatrologos.jpg]]

Fernando at 01:32, 12 February 2011

Fernando — Sat, 12 Feb 2011 01:32:05 GMT

←Older revision		Revision as of 01:32, 12 February 2011
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	Back to main page[[http://openwetware.org/wiki/De_la_Cruz_Lab]]		Back to main page[[http://openwetware.org/wiki/De_la_Cruz_Lab]]
-		+	http://grupos.unican.es/intergenomica/

	[[Image:cuatrologos.jpg]]		[[Image:cuatrologos.jpg]]

	== [[Image:Ingprot.]] ==		== [[Image:Ingprot.]] ==
-	~~http://grupos.unican.es/intergenomica/~~	+
	'''''The conjugative relaxases as a target for the inhibition of the dissemination of antibiotic resistance '''''		'''''The conjugative relaxases as a target for the inhibition of the dissemination of antibiotic resistance '''''
	DNA transfer allows bacterial evolution and adaptation to the changing environment. This mechanism is used for the transfer of antibiotic resistance genes being a huge health problem. Thus, some pathogenic bacteria are immune to the actual drugs and this resistance is spreading in a dangerous and alarming way. The problem is mainly important in hospitals where the constant use of antibiotics promotes the generation of resistant strains. [[Image:trwC.jpg\|frame\|right\|TrwC protein in complex with target DNA]]Only in the USA, there are 2 million cases of hospital infections per year, 70,000 of which are lethal. The propagation of the infections is a growing threat not just for the patients, but for the hospital workers. The economic expense is also incredibly high with up to ten thousand million USD only in the USA. Regarding DNA transfer by bacterial conjugation, the protein involved in the DNA transfer initiation (relaxase) is a key component in the process. Thus, a detailed knowledge of the biochemistry of the reaction and the three dimensional structure of the relaxase could be the way for the finding of new DNA transfer inhibitors. This work could help the design of new drugs that could prevent that the bacteria become resistant by the inhibition of the relaxase function.		DNA transfer allows bacterial evolution and adaptation to the changing environment. This mechanism is used for the transfer of antibiotic resistance genes being a huge health problem. Thus, some pathogenic bacteria are immune to the actual drugs and this resistance is spreading in a dangerous and alarming way. The problem is mainly important in hospitals where the constant use of antibiotics promotes the generation of resistant strains. [[Image:trwC.jpg\|frame\|right\|TrwC protein in complex with target DNA]]Only in the USA, there are 2 million cases of hospital infections per year, 70,000 of which are lethal. The propagation of the infections is a growing threat not just for the patients, but for the hospital workers. The economic expense is also incredibly high with up to ten thousand million USD only in the USA. Regarding DNA transfer by bacterial conjugation, the protein involved in the DNA transfer initiation (relaxase) is a key component in the process. Thus, a detailed knowledge of the biochemistry of the reaction and the three dimensional structure of the relaxase could be the way for the finding of new DNA transfer inhibitors. This work could help the design of new drugs that could prevent that the bacteria become resistant by the inhibition of the relaxase function.

Fernando: /* Image:Ingprot. */

Fernando — Sat, 12 Feb 2011 01:31:27 GMT

Image:Ingprot.

←Older revision		Revision as of 01:31, 12 February 2011
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	== [[Image:Ingprot.]] ==		== [[Image:Ingprot.]] ==
-		+	http://grupos.unican.es/intergenomica/
	'''''The conjugative relaxases as a target for the inhibition of the dissemination of antibiotic resistance '''''		'''''The conjugative relaxases as a target for the inhibition of the dissemination of antibiotic resistance '''''
	DNA transfer allows bacterial evolution and adaptation to the changing environment. This mechanism is used for the transfer of antibiotic resistance genes being a huge health problem. Thus, some pathogenic bacteria are immune to the actual drugs and this resistance is spreading in a dangerous and alarming way. The problem is mainly important in hospitals where the constant use of antibiotics promotes the generation of resistant strains. [[Image:trwC.jpg\|frame\|right\|TrwC protein in complex with target DNA]]Only in the USA, there are 2 million cases of hospital infections per year, 70,000 of which are lethal. The propagation of the infections is a growing threat not just for the patients, but for the hospital workers. The economic expense is also incredibly high with up to ten thousand million USD only in the USA. Regarding DNA transfer by bacterial conjugation, the protein involved in the DNA transfer initiation (relaxase) is a key component in the process. Thus, a detailed knowledge of the biochemistry of the reaction and the three dimensional structure of the relaxase could be the way for the finding of new DNA transfer inhibitors. This work could help the design of new drugs that could prevent that the bacteria become resistant by the inhibition of the relaxase function.		DNA transfer allows bacterial evolution and adaptation to the changing environment. This mechanism is used for the transfer of antibiotic resistance genes being a huge health problem. Thus, some pathogenic bacteria are immune to the actual drugs and this resistance is spreading in a dangerous and alarming way. The problem is mainly important in hospitals where the constant use of antibiotics promotes the generation of resistant strains. [[Image:trwC.jpg\|frame\|right\|TrwC protein in complex with target DNA]]Only in the USA, there are 2 million cases of hospital infections per year, 70,000 of which are lethal. The propagation of the infections is a growing threat not just for the patients, but for the hospital workers. The economic expense is also incredibly high with up to ten thousand million USD only in the USA. Regarding DNA transfer by bacterial conjugation, the protein involved in the DNA transfer initiation (relaxase) is a key component in the process. Thus, a detailed knowledge of the biochemistry of the reaction and the three dimensional structure of the relaxase could be the way for the finding of new DNA transfer inhibitors. This work could help the design of new drugs that could prevent that the bacteria become resistant by the inhibition of the relaxase function.
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	'''''People working in this area'''''		'''''People working in this area'''''
	Dr Gabriel Moncalian.[[http://openwetware.org/wiki/Dr._Gabriel_Moncali%C3%A1n]]		Dr Gabriel Moncalian.[[http://openwetware.org/wiki/Dr._Gabriel_Moncali%C3%A1n]]
-	~~Dr Blanca Gonzalez.[[http://openwetware.org/wiki/Dra._Blanca_Gonz%C3%A1lez]]~~
	Yera Tena.[[http://openwetware.org/wiki/Yera_Tena]]		Yera Tena.[[http://openwetware.org/wiki/Yera_Tena]]
	Juan Villa [[http://openwetware.org/wiki/Juan_Villa]]		Juan Villa [[http://openwetware.org/wiki/Juan_Villa]]
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	'''''Financial support by'''''		'''''Financial support by'''''
	[[Image:fingabi]][[Image:FSE.jpg]]		[[Image:fingabi]][[Image:FSE.jpg]]
-
-
-
-
-

	== [[Image:Molmotors.jpg]] ==		== [[Image:Molmotors.jpg]] ==

Fernando at 14:00, 2 April 2008

Fernando — Wed, 02 Apr 2008 14:00:41 GMT

←Older revision		Revision as of 14:00, 2 April 2008
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	'''''Financial support by'''''		'''''Financial support by'''''
-	[[Image:fingabi]]	+	[[Image:fingabi]][[Image:FSE.jpg]]

Fernando at 16:13, 7 March 2008

Fernando — Fri, 07 Mar 2008 16:13:50 GMT

←Older revision		Revision as of 16:13, 7 March 2008
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	Back to main page[[http://openwetware.org/wiki/De_la_Cruz_Lab]]		Back to main page[[http://openwetware.org/wiki/De_la_Cruz_Lab]]
		+
		+
	[[Image:cuatrologos.jpg]]		[[Image:cuatrologos.jpg]]

Fernando at 16:13, 7 March 2008

Fernando — Fri, 07 Mar 2008 16:13:40 GMT

←Older revision		Revision as of 16:13, 7 March 2008
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-		+	Back to main page[[http://openwetware.org/wiki/De_la_Cruz_Lab]]
-		+
	[[Image:cuatrologos.jpg]]		[[Image:cuatrologos.jpg]]

Fernando at 16:12, 7 March 2008

Fernando — Fri, 07 Mar 2008 16:12:37 GMT

←Older revision		Revision as of 16:12, 7 March 2008
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-	~~[[Media:Conjugation]]~~	+

	[[Image:cuatrologos.jpg]]		[[Image:cuatrologos.jpg]]

Fernando: /* Image:Molmotors.jpg */

Fernando — Thu, 07 Feb 2008 11:10:30 GMT

Image:Molmotors.jpg

←Older revision		Revision as of 11:10, 7 February 2008
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	Alejandro Peña.[[http://openwetware.org/wiki/Alejandro_Pe%C3%B1a]]		Alejandro Peña.[[http://openwetware.org/wiki/Alejandro_Pe%C3%B1a]]
	Sandra Zunzunegui.[[http://openwetware.org/wiki/Sandra_Zunzunegui]]		Sandra Zunzunegui.[[http://openwetware.org/wiki/Sandra_Zunzunegui]]
		+
	[[Image:grupoelena.jpg]]		[[Image:grupoelena.jpg]]

Fernando at 18:23, 5 February 2008

Fernando — Tue, 05 Feb 2008 18:23:28 GMT

←Older revision		Revision as of 18:23, 5 February 2008
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-	'''''Financial support by'''''	+	'''''Financial support by'''''[[Image:fundingfernando.jpg]]

Fernando at 18:14, 5 February 2008

Fernando — Tue, 05 Feb 2008 18:14:31 GMT

←Older revision		Revision as of 18:14, 5 February 2008
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	[[Image:grupofernando.jpg]]		[[Image:grupofernando.jpg]]
		+
		+
		+	'''''Financial support by'''''