Defining the network of ROP GTPase signalling and its regulation in root hair development.: Difference between revisions
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*Rho Guanine nucleotide Dissociation Inhibitors (GDIs) | *Rho Guanine nucleotide Dissociation Inhibitors (GDIs) | ||
*Rho GTPase activating proteins (GAPs). | *Rho GTPase activating proteins (GAPs). | ||
[[Image:GTPase Pic.gif]] | |||
Our previous work (Jones et al, 2002) has shown that the over-expression of the Rho small GTPase ROP2 in Arabidopsis produces a root hair phenotype similar to the loss of function scn1 mutants (Parker et al, 2000.) The SCN1 locus (Parker et al, 2000) encodes a Rho-GDI (AtROPGDI1), which in other systems negatively regulate Rho GTPases by sequestering the protein away from the plasma membrane. | Our previous work (Jones et al, 2002) has shown that the over-expression of the Rho small GTPase ROP2 in Arabidopsis produces a root hair phenotype similar to the loss of function scn1 mutants (Parker et al, 2000.) The SCN1 locus (Parker et al, 2000) encodes a Rho-GDI (AtROPGDI1), which in other systems negatively regulate Rho GTPases by sequestering the protein away from the plasma membrane. | ||
Revision as of 06:48, 5 September 2006
Matt Smallman
Contact Info
Matt Smallman School of Biological Sciences, University of Bristol, Woodland Road, Bristol. BS8 1UG UK
matt.smallman@bristol.ac.uk
Link to main Grierson Lab page
Education
- 2004-present, PhD, University of Bristol
- 2003, MSc, Nottingham Trent
- 1999, BSc (Hons), Oxford Brookes University
Defining the network of ROP GTPase signalling and its regulation in root hair development
Rho small GTPases are conserved molecular switches in eukaryotic signal transduction involved in a variety of biological processes such as the establishment of cell polarity and actin remodeling. The GTPase switch is closely controlled through regulatory mechanism involving at least two kinds of negative regulators:
- Rho Guanine nucleotide Dissociation Inhibitors (GDIs)
- Rho GTPase activating proteins (GAPs).
Our previous work (Jones et al, 2002) has shown that the over-expression of the Rho small GTPase ROP2 in Arabidopsis produces a root hair phenotype similar to the loss of function scn1 mutants (Parker et al, 2000.) The SCN1 locus (Parker et al, 2000) encodes a Rho-GDI (AtROPGDI1), which in other systems negatively regulate Rho GTPases by sequestering the protein away from the plasma membrane.
