Dent Lab

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[[Sharon Dent Lab at University of Texas M.D. Anderson Cancer Center| <font face="trebuchet ms" style="color:#ffffff"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Dent_Lab| <font face="trebuchet ms" style="color:#ffffff"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Dent_Lab:Contact | <font face="trebuchet ms" style="color:#ffffff"> '''Contact''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Dent_Lab:Contact | <font face="trebuchet ms" style="color:#ffffff"> '''Contact''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Dent_Lab:Back Door | <font face="trebuchet ms" style="color:#ffffff"> '''Internal''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 
[[Dent_Lab:Lab Members | <font face="trebuchet ms" style="color:#ffffff"> '''Lab Members''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Dent_Lab:Lab Members | <font face="trebuchet ms" style="color:#ffffff"> '''Lab Members''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Dent_Lab:Reprints | <font face="trebuchet ms" style="color:#ffffff"> '''Publications''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Dent_Lab:Reprints | <font face="trebuchet ms" style="color:#ffffff"> '''Publications''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Dent_Lab:Research | <font face="trebuchet ms" style="color:#ffffff"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Dent_Lab:Meetings| <font face="trebuchet ms" style="color:#ffffff"> '''Meetings''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Dent_Lab:Talks | <font face="trebuchet ms" style="color:#ffffff"> '''Talks''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Dent_Lab:Protocols| <font face="trebuchet ms" style="color:#ffffff"> '''Protocols''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Dent_Lab:Back Door | <font face="trebuchet ms" style="color:#ffffff"> '''Internal''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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Welcome to our lab at U.T. - M.D. Anderson Cancer Center. The lab is supervised by Dr. Sharon Y. R. Dent, Ph.D. in the Department of Biochemistry and Molecular Biology. We are located on the 9th floor of the Mitchell Basic Sciences Research Building.
Welcome to our lab at U.T. - M.D. Anderson Cancer Center. The lab is supervised by Dr. Sharon Y. R. Dent, Ph.D. in the Department of Biochemistry and Molecular Biology. We are located on the 9th floor of the Mitchell Basic Sciences Research Building.
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Our lab studies the role of chromatin and chromatin modifying proteins in regulating gene expression. We use a variety of model systems to address the above question including; Saccharomyces cerevesiae, mouse models, embryonic stem (ES) cells, and various tissue culture cell lines.
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Our lab studies the role of chromatin and chromatin modifying proteins in regulating gene expression. We use a variety of model systems to address the above question including; ''Saccharomyces cerevesiae'', mouse models, embryonic stem (ES) cells, and various tissue culture cell lines.
== Current projects ==
== Current projects ==
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Yeast:
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'''Yeast:'''
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<br>Genetic and biochemical approaches to decipher the means of chromatin organization and transcriptional repression by the Ssn6-Tup1 repressor complex. Similar approaches to understand the possible crosstalk between various histone modifying enzymes.  
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Genetic and biochemical approaches to decipher the means of chromatin organization and transcriptional repression by the Ssn6-Tup1 repressor complex. Similar approaches to understand the possible crosstalk between various histone modifying enzymes.  
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Mouse:
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'''Mouse:'''
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<br>Gene targeting and transgenic approaches to understand the functions of histone acetyltransferases (GCN5 and PCAF) during mammalian development.  
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Gene targeting and transgenic approaches to understand the functions of histone acetyltransferases (GCN5 and PCAF) during mammalian development.  
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Tissue culture/cell lines:
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'''Tissue culture/cell lines:'''
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<br>
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<br>Projects involve transfection, chromatin immunoprecipitation, and biochemical approaches to examine the mechanisms of histone modifying proteins and their interaction with other transcriptional regulators.
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Projects involve transfection, chromatin immunoprecipitation, and biochemical approaches to examine the mechanisms of histone modifying proteins and their interaction with other transcriptional regulators.
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[[Category:Dent]]
[[Category:Dent]]

Current revision

Home        Contact        Lab Members        Publications        Meetings        Protocols        Links        Internal       


Lab Interests

Welcome to our lab at U.T. - M.D. Anderson Cancer Center. The lab is supervised by Dr. Sharon Y. R. Dent, Ph.D. in the Department of Biochemistry and Molecular Biology. We are located on the 9th floor of the Mitchell Basic Sciences Research Building.

Our lab studies the role of chromatin and chromatin modifying proteins in regulating gene expression. We use a variety of model systems to address the above question including; Saccharomyces cerevesiae, mouse models, embryonic stem (ES) cells, and various tissue culture cell lines.

Current projects

Yeast:
Genetic and biochemical approaches to decipher the means of chromatin organization and transcriptional repression by the Ssn6-Tup1 repressor complex. Similar approaches to understand the possible crosstalk between various histone modifying enzymes.

Mouse:
Gene targeting and transgenic approaches to understand the functions of histone acetyltransferases (GCN5 and PCAF) during mammalian development.

Tissue culture/cell lines:
Projects involve transfection, chromatin immunoprecipitation, and biochemical approaches to examine the mechanisms of histone modifying proteins and their interaction with other transcriptional regulators.

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