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Publications

Papers

1. Li X, Zhang X, Wang J, Zhao S, Liu G, Du Y*, ‘Micro-scaffold Array Chip for upgrading cell-based High-throughput drug testing to 3D using benchtop equipment', Lab on Chip DOI:10.1039/C3LC51103K (2013) (reported by chemistryworld: http://www.rsc.org/chemistryworld/2013/11/high-throughput-chip-drug-screening-3d)
2. Xie L, Yan X, Du Y* ‘An aptamer based wall-less LSPR array chip for label-free and high throughput detection of biomolecules’ Biosensor and Bioelectronics 53:58-64 (2014)
3. Zhao S, Zhao H, Zhang X, Li Y, Du Y* ‘Off-the-shelf Microsponge Arrays for Facile and Efficient Construction of 3D Cellular Microenvironment for Versatile cell-based assays’ Lab on Chip 13 (12), 2350 - 2358(2013)
4. Qi H, Ghodousi M, Du Y, Grun C, Bae H, Yin P, Khademhosseini A. ‘DNA-directed self-assembly of shape-controlled hydrogels’ Nature Communication. Sep 9;4:2275. doi: 10.1038/ncomms3275. (2013)
5. Chen H, Zeng Y, Liu W, Zhao S, Wu J, Du Y* ‘Multifaceted applications of nanomaterials in cell engineering and therapy’ Biotechnology Advances 31(5): 638–653 (2013)
6. Wu L, Wu J, Zhou Y, Tang X, Du Y, Hu Y. ‘Enhanced antitumor efficacy of cisplatin by tirapazamine-transferrin conjugate’. Int J Pharm. 431(1-2):190-6 (2012)
7. Men K, Liu W, Li L, Duan X, Wang P, Gou M, Wei X, Gao X, Wang B, Du Y, Huang M, Chen L, Qian Z, Wei Y ‘Delivering instilled hydrophobic drug to the bladder by a cationic nanoparticle and thermo-sensitive hydrogel composite system’ Nanoscale; 4(20):6425-33 (2012)
8. Zhen Xu, Jingyu Wang, Yanan Du* ‘Recent Advances in Embryonic Stem Cell Engineering towards tailored lineage differentiation’; Emerging Trends in Cell and Gene Therapy, edited by Ram I. Mahato and Michael Danquah; AAPS-Springer (2013)
9. Xiaokang Li, Claudia wittkowske, Rui Yao, Yanan Du*, 'Hydrogel as stem cell niche for in vivo applications in regenerative medicine'; Chapter 2 in “Biomaterials and Stem Cells in Regenerative Medicine” edited by Murugan Ramalingam, Seeram Ramakrishna and Serena Best; CRC Press (2012)
10. Hui Chen, Xiaokang Li, Yanan Du*, '1D~3D Nano-engineered Materials for Biomedical Application; Chapter 1 in‘"Integrated Biomaterials for Medical Applications"; Edited by Murugan Ramalingam and Ashutosh Tiwari; VBRI Press (2012)

Patents

1. ‘用于构建三维微环境的方法和装置’， 杜亚楠 赵姗 中国专利申请（2011）(Chinese Patent)
2. ‘一种实现细胞集落均质性生长的装置和方法’ 杜亚楠 姚睿 王靖宇 中国专利申请（2011）(Chinese Patent)
3. ‘基于透明海绵支架构建三维细胞外购件的方法和装置’杜亚楠 赵珊， PCT/CN2012/001013（2012） (PCT Patent)
4. ‘细胞集落体外培养装置及其用途’杜亚楠，姚睿，王靖宇 PCT/CN2012/086149 (2012)(PCT Patent)
5. ‘基于微冰胶构建注射型三维细胞微环境的系统和方法’杜亚楠，刘伟，李雅倩 中国专利申请 （2012） (Chinese Patent)
6. ‘基于局域表面等离子体共振的无实体壁阵列检测芯片’杜亚楠，谢丽萍，鄢小君 中国专利申请 （2013）(Chinese Patent)
7. ‘生物反应装置及其制备方法和应用’杜亚楠，李晓康，张新勇 中国专利申请 （2013）(Chinese Patent)

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Before Tsinghua

Journal Articles

1. Y. Du, M. Ghodousi, H. Qi, N. Haas, W. Xiao, A. Khademhosseini ‘Sequential assembly of cell-laden hydrogel constructs to engineer vascular-like microchannels’ Biotechnology and Bioengineering "in press" (2011)
2. H. Qi, Y. Du, L. Wang, H. Bae, H. Kaji, Ali Khademhosseini ‘Patterning Single mouse embryonic bodies with defined polarities in 3D hybrid microgel’, Advanced materials (2011) 22(46):5276-81 (co-first author) (cover, reported by Technology review, Material review)
3. Yanagawa F, Kaji H, Jang YH, Bae H, Y. Du, Fukuda J, H. Qi, A. Khademhosseini ‘Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs'. J Biomed Mater Res A . in press (2011)
4. Xiao W, He J, Nichol JW, Wang L, Hutson CB, Wang B, Y. Du, Fan H, Khademhosseini A. ‘Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating polymer network hydrogels.’ Acta Biomater . in press (2011)
5. J. He, Y. Du, Y. Guo, M. Hancock, B. Wang, H. Shin, J. Wu, D. Li, A. Khademhosseini ‘Microfluidic synthesis of composite cross-gradient materials for Investigating cell-biomaterial interactions’ Biotechnology and Bioengineering 2010 108:175-85 (co-first author)
6. J. Wu, I. Wheeldon, Y. Guo, T. Lu, Y. Du, B. Wang, J. He, Y. Hu, A. Khademhosseini ‘Nanoliter-Scale Chamber array for High Throughput Screening of Drug Cytotoxicity and Drug-Drug Interactions, Biomaterials, 32:841-8 (2011)
7. Y. Du, M. Hancock, J. He, J. Villa-Uribe, B. Wang, D. Cropek, A. Khademhosseini ‘Convection driven generation of long-range material gradients’ Biomaterials 31:2686-2694 (2010)
8. Y. Du, M. Ghodoosi, E. Lo, M. Vidula, O. Emir, A. Khademhosseini ‘Surface-directed assembly of cell-laden microgels as 3D tissue constructs’ Biotechnology and Bioengineering 105(3): 655-662 (2010)
9. J. He, Y. Du, J. Villa-Uribe, A. Khademhosseini ‘Rapid generation of hydrogel chemical/mechanical gradient in a simple microfluidic device for biological applications’ Advanced Functional Materials 20(1): 131-137 (2010) (co-first author)
10. N. Kachouie, Y. Du, H. Bae, M. Khabiry, A.F. Ahari, B. Zamanian, J. Fukuda, A. Khademhosseini ‘Directed assembly of cell-laden hydrogels for engineering functional tissues’ Organogenesis in press
11. Z. Shi, N. Chen, Y. Du, A. Khademhosseini, M. Alber ‘Stochastic model of self-assembly of cell-laden hydrogels’ Physical Review E 80: 061901 (2010)
12. Y. Du, J. Shim, M. Vidula, Matthew J. Hancock, E. Lo, B. Chung, M. Khabiry, J. Borenstein, D. Cropek, A. Khademhosseini ‘Rapid generation of spatially and temporally controllable centimeter-length concentration gradients in a microfluidic device’ Lab on a Chip 9(6): 741-848 (2009) (cover)
13. M. Khabiry, B. Chung, M. Hancock, H. Soundararajan, Y. Du, D. Cropek, A. Khademhosseini ‘Cell Docking within Double Grooved Substrates in a Microfluidic Device’ Small 5(10): 1186-1194 (2009)
14. Y. Du, E. Lo, S. Ali, A. Khademhosseini, ‘Directed assembly of cell-laden microgels for fabrication of 3D tissue engineering constructs’ Proceedings of the National Academy of Sciences 105(28): 9522-7 (2008) (Reported by Nature, Technology Review, Focus, Scientific America and as spotlight at MIT website homepage)
15. Y. Du, E. Lo, M. Vidula, M. Khabiry, A. Khademhosseini “Method of Bottom-up Directed Assembly of Cell-Laden Microgels’ Cellular and Molecular Bioengineering (2008) 1: 157-162 (Outstanding paper award in Biomedical Engineering Society 2008)
16. Y. Du, R. Han, S. Ng, F. Wen, T. Wohland, H. Yu ‘A Novel Synthetic Sandwich Culture of 3D Hepatocyte Monolayer’ Biomaterials 29: 290-301 (2008)
17. Y. Toh, J. Zhang, Y. Khong, Y. Du, W. Sun, H. Yu ‘Capillary electrophoresis with laser induced fluorescence detection (CE-LIF) as a common analytical platform for sensitive quantification of hepatic metabolic functions’ Analyst 133(3): 326-30 (2008)
18. Y. Du, R. Han, S. Ng, J. Ni, W. Sun, T. Wohland, S. Ong, H. Yu ‘Identification and characterization of a novel pre-spheroid 3D hepatocyte monolayer on galactosylated substratum’ Tissue Engineering 13(7): 1455-1468 (2007)
19. X. Pan, C. Aw, Y. Du, H. Yu, T. Wohland ‘Characterization of poly(acrylic acid) diffusion dynamics on the grafted surface of poly(ethylene terephthalate) films by fluorescence correlation spectroscopy’ Biophysical Reviews and Letters 1 (4): 1-9 (2006)
20. Y. Du, S. Chia, R. Han, S. Chang, H. Yu, "3D hepatocyte monolayer on hybrid RGD/galactose substratum” Biomaterials 27: 5669-5680 (2006)

Book chapters

1. Ali Khademhosseini, Yanan Du, Bimal Rajalingam, Joseph P. Vacanti, Robert Langer, ‘Microscale Technologies for Tissue Engineering’; In “Advanced in tissue engineering ”; Edited by Julia Polak, Sakis Mantalaris and Sian E Harding; Imperial College Press (2008), P349-369, (co-first author)
2. Yanan Du, Donald Cropek, Mohammad R. Kaazempur Mofrad, Eli J. Weinberg, Ali Khademhosseini, Jeffrey Borenstein, ‘Microfluidic systems for engineering vascularized tissue constructs’; In “Microfluidics for Biological Applications”; Edited by Wei-Cheng Tian and Erin Finehout; Springer (2009)
3. Pilnam Kim, Yanan Du, Ali Khademhosseini, Robert Langer, Kahp Y. Suh, ‘Unconventional patterning methods for BioNEMS’; In “Nanopatterning and Applications”; Edited by John A. Rogers and Hong H. Lee; Wiley (2009) (co-first author)
4. Yanan Du '3D HEPATOCYTE MONOLAYER FOR HEPATOCYTE BASED APPLICATIONS' LAP LAMBERT Academic Publishing (2010)
5. Adam Hacking, Yanan Du, Ali Khademhosseini, ‘Polymer patterning for biological application’; In “Comprehensive Polymer Science, 2nd edition”; Edited by Martin Moeller and Krzysztof Matyjaszewski; Elsevier (expected 2011)

Patents

1. Hanry Yu, Yanan Du, Rongbin Han ‘Stabilizing a novel 3D hepatocyte monolayer culture by a hybrid bioactive substratum for hepatocyte-based applications’ PCT/SG2007/000147 (2008), EP Application No./Patent No.: 07748592.6 – 1222 (2009)
2. Ali Khademhosseini, Yanan Du, ‘Method and system for generating spatially and temporally controllable concentration gradients’ PCT/US2009/064555 (2009)
3. Ali Khademhosseini, Jeffrey Borenstein, Hojae Bae, Yanan Du, Jane Wang, Jason Nichol, Robert Langer, ‘Microfluidic construction of vascularized tissues’, Invention disclosure submitted (2010)
4. Ali Khademhosseini, Masoud Khabiry, Bong Geun Chung, Matthew Hancock, and Yanan Du, ‘Double-groove cell docking’ Invention disclosure submitted (BWH, NP-043214-066771) (2010)