Dziubla:Publications

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M. Howard, X. Lu, J. Rinehart, M. Jay and T. Dziubla* “[http://www.ncbi.nlm.nih.gov/pubmed/21190351 Physicochemical Characterization of Nanotemplate Engineered Solid Lipid Nanoparticles]” Langmuir (2010)
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17. E. Hood, E. Simone, P.P. Wattamwar, T.D. Dziubla and V.R. Muzykantov, “[http://www.ncbi.nlm.nih.gov/pubmed/21929460 Nanocarriers for vascular delivery of antioxidants]”, Review article, Nanomedicine (Accepted)
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J. Kim, M. Howard, T. Dziubla, J. Rinehart, M. Jay and X. Lu * “[http://www.ncbi.nlm.nih.gov/pubmed/21158414 Uniformity of Drug Payload and its Effect on Stability of Solid Lipid Nanoparticles Containing an Ester Prodrug]” ACS Nano (accepted)
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16. V.V. Shuvaev, M.A. Ilies, E. Simone, S. Zaitsev, Y. Kim, S. Cai, A. Mahmud ,T. Dziubla ,S. Muro, D.E. Discher, V.R. Muzykantov* “[http://www.ncbi.nlm.nih.gov/pubmed/21838300 Endothelial Targeting of Antibody-Decorated Polymeric Filomicelles]” ACS Nano (Epub ahead of Print 2011)
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J. Medley, Heisterberg J, and T Dziubla* “[http://www.ncbi.nlm.nih.gov/pubmed/20573320 Synthesis and Characterization of CREKA-Targeted Polymers for the Disruption of Fibrin Gel Matrix Propagation.]” J Biomater Sci:Poly Ed (E Pub 2010)
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15. P. Wattamwar, S. Hardas, D.A. Butterfield, K. Anderson, T. Dziubla* “[http://www.ncbi.nlm.nih.gov/pubmed/21976443 Tuning of the Pro-oxidant and Antioxidant Activity of Trolox Through the Controlled Release from Biodegradable Poly(trolox ester) Polymers]” J. Biomed Mater Res A, (EPub ahead of Print)
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P. Wattamwar, Y. Mo, R. Wan, R. Palli, Q. Zhang and T. Dziubla*, “[http://onlinelibrary.wiley.com/doi/10.1002/adfm.200900839/abstract Antioxidant Activity of Degradable Polymer Poly(trolox ester) to Suppress Oxidative Stress Injury in the Cells.]” Advanced Functional Materials 20:147-154 (2010)
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14. Medley JM, Kaplan E, Oz HS, Sundararaj SC, Puleo DA, Dziubla TD*. “[http://www.ncbi.nlm.nih.gov/pubmed/21695779 Fibrin-targeted block copolymers for the prevention of postsurgical adhesions.]” J Biomed Mater Res B Appl Biomater. doi: 10.1002/jbm.b.31876 (2011)
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Y Ma, Y Xiong*, J Zhai, H Zhu, and T Dziubla, “[http://www.ncbi.nlm.nih.gov/pubmed/20352082 Fractionation and Evaluation of Radical Scavenging Peptides from in vitro Digests of Buckwheat Protein.]” Food Chemistry 118:582-588 (2010)
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13. M. Howard, X. Lu, J. Rinehart, M. Jay and T. Dziubla* “[http://www.ncbi.nlm.nih.gov/pubmed/21190351 Physicochemical Characterization of Nanotemplate Engineered Solid Lipid Nanoparticles]” Langmuir 27(5):1964-71 (2011)
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J. Medley, E. Beane, E. Kaplan and T Dziubla* “[http://www.ncbi.nlm.nih.gov/pubmed/19607939 Block copolymers for the rational design of self-forming postsurgical adhesion barriers.]” Acta Biomaterialia 6:72-82 (2010)
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12. J. Kim, M. Howard, T. Dziubla, J. Rinehart, M. Jay and X. Lu* “[http://www.ncbi.nlm.nih.gov/pubmed/21158414 Uniformity of Drug Payload and its Effect on Stability of Solid Lipid Nanoparticles Containing an Ester Prodrug]” ACS Nano (2010)
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E Simone*, T Dziubla, D Discher, and V Muzykantov. “[http://www.ncbi.nlm.nih.gov/pubmed/19385657 Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase.]” Biomacromolecules 10:1324-30 (2009)
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11. J. Medley, Heisterberg J, and T Dziubla* “[http://www.ncbi.nlm.nih.gov/pubmed/20573320 Synthesis and Characterization of CREKA-Targeted Polymers for the Disruption of Fibrin Gel Matrix Propagation.]” J Biomater Sci:Poly Ed 22(10):1363-78 (2011)
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E Simone*, T. Dziubla, E Arguiri, V Vardon, V Shuvaev, M Christofidou-Solomidou and V Muzykantov. “[http://www.ncbi.nlm.nih.gov/pubmed/18956141 Loading PEG-catalase into filamentous and spherical polymer nanocarriers]” Pharmaceutical Research 26:250-60 (2009)
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10. P. Wattamwar, Y. Mo, R. Wan, R. Palli, Q. Zhang and T. Dziubla*, “[http://onlinelibrary.wiley.com/doi/10.1002/adfm.200900839/abstract Antioxidant Activity of Degradable Polymer Poly(trolox ester) to Suppress Oxidative Stress Injury in the Cells.]” Advanced Functional Materials 20:147-154 (2010)
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E. Simone, T.D. Dziubla, and V. R Muzykantov., “Polymeric Carriers: Role of Geometry in Drug Delivery.” Expert Opinion on Drug Delivery 5:1283-1300 (2008)
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9. Y Ma, Y Xiong*, J Zhai, H Zhu, and T Dziubla, “[http://www.ncbi.nlm.nih.gov/pubmed/20352082 Fractionation and Evaluation of Radical Scavenging Peptides from in vitro Digests of Buckwheat Protein.]Food Chemistry 118:582-588 (2010)
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M. Howard, M Jay, T. Dziubla, X. Lu*, “PEGylation of Nanocarrier Drug Delivery Systems: State of the Art.” J Biomed Nanotech 4:133-148 (2008)  
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8. J. Medley, E. Beane, E. Kaplan and T Dziubla* “[http://www.ncbi.nlm.nih.gov/pubmed/19607939 Block copolymers for the rational design of self-forming postsurgical adhesion barriers.]Acta Biomaterialia 6:72-82 (2010)
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C. Garnacho, R. Dhami, E. Simone, T. Dziubla, J. Leferovich, E. H. Schuchman, V. Muzykantov, and S. Muro*. “Delivery of acid sphingomyelinase in normal and Niemann-Pick disease mice using ICAM-1-targeted polymer nanoparticles” JPET 325:400-408 (2008)
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7. E Simone*, T Dziubla, D Discher, and V Muzykantov. “[http://www.ncbi.nlm.nih.gov/pubmed/19385657 Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase.]” Biomacromolecules 10:1324-30 (2009)
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T.D. Dziubla*, V.V. Shuvaev, N.K. Hong, B. Hawkins, M. Muniswamy, H. Takano, E. Simone, M.T. Nakada, A. Fisher, S.M. Albelda, and V.R. Muzykantov, “Endothelial Targeting of Semi-permeable Polymer Nanocarriers for Enzyme Therapies.Biomaterials 2:215-27 (2008)
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6. E Simone*, T. Dziubla, E Arguiri, V Vardon, V Shuvaev, M Christofidou-Solomidou and V Muzykantov. “[http://www.ncbi.nlm.nih.gov/pubmed/18956141 Loading PEG-catalase into filamentous and spherical polymer nanocarriers]Pharmaceutical Research 26:250-60 (2009)
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E. Simone*, T. Dziubla, F. Colon, D. Discher and V.R. Muzykantov. “Amphiphilicity of PEG-PLA diblock copolymer controls the formulation and morphology of nanocarriers protecting loaded therapeutic enzyme from proteolysis” Biomacromolecules 8:3914-21 (2007)  
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5. E. Simone, T.D. Dziubla, and V. R Muzykantov*, “[http://www.ncbi.nlm.nih.gov/pubmed/19040392 Polymeric Carriers: Role of Geometry in Drug Delivery.]” Expert Opinion on Drug Delivery 5:1283-1300 (2008)
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S. Muro*, T.D. Dziubla, W. Qui, J. Leferovich, X. Cui, E. Berk and V.R. Muzykantov  “Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to ICAM-1.” JPET 317(3):1161-9 (2006)
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4. M. Howard, M Jay, T. Dziubla, X. Lu*, “[http://www.ingentaconnect.com/content/asp/jbn/2008/00000004/00000002/art00002 PEGylation of Nanocarrier Drug Delivery Systems: State of the Art.]J Biomed Nanotech 4:133-148 (2008)  
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Ding BS, Dziubla T, Shuvaev VV, Muro S, Muzykantov VR. “Advanced drug delivery systems that target the vascular endothelium.” Mol Interv. 2:98-112 (2006)
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3. C. Garnacho, R. Dhami, E. Simone, T. Dziubla, J. Leferovich, E. H. Schuchman, V. Muzykantov, and S. Muro*. “[http://www.ncbi.nlm.nih.gov/pubmed/18287213 Delivery of acid sphingomyelinase in normal and Niemann-Pick disease mice using ICAM-1-targeted polymer nanoparticles]” JPET 325:400-408 (2008)
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T.D. Dziubla*, A. Karim and V. Muzykantov, “Polymer nanocarriers (PNC) protect loaded catalase cargo from proteolysis.” Journal of Controlled Release 102(2), 427-439, (2005)  
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2. T.D. Dziubla*, V.V. Shuvaev, N.K. Hong, B. Hawkins, M. Muniswamy, H. Takano, E. Simone, M.T. Nakada, A. Fisher, S.M. Albelda, and V.R. Muzykantov, “[http://www.ncbi.nlm.nih.gov/pubmed/17950837 Endothelial Targeting of Semi-permeable Polymer Nanocarriers for Enzyme Therapies.]” Biomaterials 2:215-27 (2008)
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T.D. Dziubla and A.M. Lowman*, “Vascularization of PEG-grafted macroporous hydrogel sponges: a 3-dimensional in vitro angiogenesis model utilizing human microvascular endothelial cells.” Journal of Biomedical Materials Research. 68A (4): 603-614, (2004)
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1. E. Simone*, T. Dziubla, F. Colon, D. Discher and V.R. Muzykantov. “[http://www.ncbi.nlm.nih.gov/pubmed/18038999 Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers.]” Biomacromolecules 8:3914-21 (2007)
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T.D. Dziubla, M.C. Torjman, J.I. Joseph, M. Murphy-Tatum and A.M. Lowman*, "Evaluation of porous networks of poly(2-hydroxyethyl methacrylate) as interfacial drug delivery devices." Biomaterials 22, 2893-2899, (2001)
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Current revision

Resources

Protocols
Equipment

  • DLS
  • Glovebox
  • Fluorimeter
  • Freeze Dryer
  • Uv-Vis
  • GPC/HPLC

Materials
Internal

Contact

Thomas Dziubla
Assistant Professor
Mat and Chem Engineering
University of Kentucky
177 F Paul Anderson Tower
Lexington, KY 40506-0046
dziubla-at-engr.uky.edu

17. E. Hood, E. Simone, P.P. Wattamwar, T.D. Dziubla and V.R. Muzykantov, “Nanocarriers for vascular delivery of antioxidants”, Review article, Nanomedicine (Accepted)

16. V.V. Shuvaev, M.A. Ilies, E. Simone, S. Zaitsev, Y. Kim, S. Cai, A. Mahmud ,T. Dziubla ,S. Muro, D.E. Discher, V.R. Muzykantov* “Endothelial Targeting of Antibody-Decorated Polymeric Filomicelles” ACS Nano (Epub ahead of Print 2011)

15. P. Wattamwar, S. Hardas, D.A. Butterfield, K. Anderson, T. Dziubla* “Tuning of the Pro-oxidant and Antioxidant Activity of Trolox Through the Controlled Release from Biodegradable Poly(trolox ester) Polymers” J. Biomed Mater Res A, (EPub ahead of Print)

14. Medley JM, Kaplan E, Oz HS, Sundararaj SC, Puleo DA, Dziubla TD*. “Fibrin-targeted block copolymers for the prevention of postsurgical adhesions.” J Biomed Mater Res B Appl Biomater. doi: 10.1002/jbm.b.31876 (2011)

13. M. Howard, X. Lu, J. Rinehart, M. Jay and T. Dziubla* “Physicochemical Characterization of Nanotemplate Engineered Solid Lipid Nanoparticles” Langmuir 27(5):1964-71 (2011)

12. J. Kim, M. Howard, T. Dziubla, J. Rinehart, M. Jay and X. Lu* “Uniformity of Drug Payload and its Effect on Stability of Solid Lipid Nanoparticles Containing an Ester Prodrug” ACS Nano (2010)

11. J. Medley, Heisterberg J, and T Dziubla* “Synthesis and Characterization of CREKA-Targeted Polymers for the Disruption of Fibrin Gel Matrix Propagation.” J Biomater Sci:Poly Ed 22(10):1363-78 (2011)

10. P. Wattamwar, Y. Mo, R. Wan, R. Palli, Q. Zhang and T. Dziubla*, “Antioxidant Activity of Degradable Polymer Poly(trolox ester) to Suppress Oxidative Stress Injury in the Cells.” Advanced Functional Materials 20:147-154 (2010)

9. Y Ma, Y Xiong*, J Zhai, H Zhu, and T Dziubla, “Fractionation and Evaluation of Radical Scavenging Peptides from in vitro Digests of Buckwheat Protein.” Food Chemistry 118:582-588 (2010)

8. J. Medley, E. Beane, E. Kaplan and T Dziubla* “Block copolymers for the rational design of self-forming postsurgical adhesion barriers.” Acta Biomaterialia 6:72-82 (2010)

7. E Simone*, T Dziubla, D Discher, and V Muzykantov. “Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase.” Biomacromolecules 10:1324-30 (2009)

6. E Simone*, T. Dziubla, E Arguiri, V Vardon, V Shuvaev, M Christofidou-Solomidou and V Muzykantov. “Loading PEG-catalase into filamentous and spherical polymer nanocarriers” Pharmaceutical Research 26:250-60 (2009)

5. E. Simone, T.D. Dziubla, and V. R Muzykantov*, “Polymeric Carriers: Role of Geometry in Drug Delivery.” Expert Opinion on Drug Delivery 5:1283-1300 (2008)

4. M. Howard, M Jay, T. Dziubla, X. Lu*, “PEGylation of Nanocarrier Drug Delivery Systems: State of the Art.” J Biomed Nanotech 4:133-148 (2008)

3. C. Garnacho, R. Dhami, E. Simone, T. Dziubla, J. Leferovich, E. H. Schuchman, V. Muzykantov, and S. Muro*. “Delivery of acid sphingomyelinase in normal and Niemann-Pick disease mice using ICAM-1-targeted polymer nanoparticles” JPET 325:400-408 (2008)

2. T.D. Dziubla*, V.V. Shuvaev, N.K. Hong, B. Hawkins, M. Muniswamy, H. Takano, E. Simone, M.T. Nakada, A. Fisher, S.M. Albelda, and V.R. Muzykantov, “Endothelial Targeting of Semi-permeable Polymer Nanocarriers for Enzyme Therapies.” Biomaterials 2:215-27 (2008)

1. E. Simone*, T. Dziubla, F. Colon, D. Discher and V.R. Muzykantov. “Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers.” Biomacromolecules 8:3914-21 (2007)

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