Evolutionary Stability - Revision history

Jason R. Kelly at 17:32, 26 August 2005

2005-08-26T17:32:13Z

←Older revision		Revision as of 17:32, 26 August 2005
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	#'''Performance Stability'''		#'''Performance Stability'''
	#*the capacity of the system to continue to function reliably given changes in the underlying DNA sequence.		#*the capacity of the system to continue to function reliably given changes in the underlying DNA sequence.
-	Note that a system that was genetically stable would by default have performance stability, but not vice-versa.	+	Note that a system that was genetically stable would by default have performance stability, but not vice-versa. Experimentally, we can evaluate methods to control the genetic and performance stability of engineered biological systems by:
-		+
-	Experimentally, we can evaluate methods to control the genetic and performance stability of engineered biological systems by:	+
	#Evaluating [[DNA sequence design to modulate evolutionary stability\|DNA sequence design]] that increases or decreases the genetic and performance stability of the system		#Evaluating [[DNA sequence design to modulate evolutionary stability\|DNA sequence design]] that increases or decreases the genetic and performance stability of the system
	#Evaluating [[Device and system design to modulate evolutionary stability\|device and system design]] that increases or decreases performance stability of the system.		#Evaluating [[Device and system design to modulate evolutionary stability\|device and system design]] that increases or decreases performance stability of the system.

	Contact: [[Jason Kelly]]		Contact: [[Jason Kelly]]

Jason R. Kelly at 17:25, 26 August 2005

2005-08-26T17:25:37Z

←Older revision		Revision as of 17:25, 26 August 2005
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	#Evaluating [[DNA sequence design to modulate evolutionary stability\|DNA sequence design]] that increases or decreases the genetic and performance stability of the system		#Evaluating [[DNA sequence design to modulate evolutionary stability\|DNA sequence design]] that increases or decreases the genetic and performance stability of the system
	#Evaluating [[Device and system design to modulate evolutionary stability\|device and system design]] that increases or decreases performance stability of the system.		#Evaluating [[Device and system design to modulate evolutionary stability\|device and system design]] that increases or decreases performance stability of the system.
		+
		+	Contact: [[Jason Kelly]]

Jason R. Kelly at 17:23, 26 August 2005

2005-08-26T17:23:01Z

←Older revision		Revision as of 17:23, 26 August 2005
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	To begin to solve this problem, we define two aspects of evolutionary stability:		To begin to solve this problem, we define two aspects of evolutionary stability:
	#'''Genetic Stability'''		#'''Genetic Stability'''
-	#*the stability of the information encoding the system (e.g. the likelihood of mutations in the DNA sequence)	+	#*the stability of the information encoding the system (i.e. the likelihood of mutations in the DNA sequence)
	#'''Performance Stability'''		#'''Performance Stability'''
	#*the capacity of the system to continue to function reliably given changes in the underlying DNA sequence.		#*the capacity of the system to continue to function reliably given changes in the underlying DNA sequence.

Jason R. Kelly at 17:22, 26 August 2005

2005-08-26T17:22:15Z

←Older revision		Revision as of 17:22, 26 August 2005
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	To begin to solve this problem, we define two aspects of evolutionary stability:		To begin to solve this problem, we define two aspects of evolutionary stability:
-	#[[Genetic Stability]]	+	#'''Genetic Stability'''
-	#*the stability of the information encoding the system -- the ~~stability~~ of the DNA sequence ~~itself.~~	+	#*the stability of the information encoding the system (e.g. the likelihood of mutations in the DNA sequence)
-	#[[Performance Stability]]	+	#'''Performance Stability'''
	#*the capacity of the system to continue to function reliably given changes in the underlying DNA sequence.		#*the capacity of the system to continue to function reliably given changes in the underlying DNA sequence.
	Note that a system that was genetically stable would by default have performance stability, but not vice-versa.		Note that a system that was genetically stable would by default have performance stability, but not vice-versa.

Jason R. Kelly at 13:28, 26 August 2005

2005-08-26T13:28:21Z

←Older revision		Revision as of 13:28, 26 August 2005
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	#*the capacity of the system to continue to function reliably given changes in the underlying DNA sequence.		#*the capacity of the system to continue to function reliably given changes in the underlying DNA sequence.
	Note that a system that was genetically stable would by default have performance stability, but not vice-versa.		Note that a system that was genetically stable would by default have performance stability, but not vice-versa.
		+
		+	Experimentally, we can evaluate methods to control the genetic and performance stability of engineered biological systems by:
		+	#Evaluating [[DNA sequence design to modulate evolutionary stability\|DNA sequence design]] that increases or decreases the genetic and performance stability of the system
		+	#Evaluating [[Device and system design to modulate evolutionary stability\|device and system design]] that increases or decreases performance stability of the system.

Jason R. Kelly at 21:33, 23 May 2005

2005-05-23T21:33:07Z

←Older revision		Revision as of 21:33, 23 May 2005
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	To begin to solve this problem, we define two aspects of evolutionary stability:		To begin to solve this problem, we define two aspects of evolutionary stability:
-	#[[~~genetic stability~~]]	+	#[[Genetic Stability]]
	#*the stability of the information encoding the system -- the stability of the DNA sequence itself.		#*the stability of the information encoding the system -- the stability of the DNA sequence itself.
-	#[[~~performance stability~~]]	+	#[[Performance Stability]]
	#*the capacity of the system to continue to function reliably given changes in the underlying DNA sequence.		#*the capacity of the system to continue to function reliably given changes in the underlying DNA sequence.
	Note that a system that was genetically stable would by default have performance stability, but not vice-versa.		Note that a system that was genetically stable would by default have performance stability, but not vice-versa.

Jason R. Kelly at 21:32, 23 May 2005

2005-05-23T21:32:18Z

←Older revision		Revision as of 21:32, 23 May 2005
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	Our engineered biological systems exist inside replicating machines (i.e., living cells). Machine replication results in spontaneous errors in the genetic information encoding our systems. As engineers, we would like to be able to design systems such that performance in the face of mutation and selection is predictable. Further, we would like to either decrease or increase the susceptibility of the system to loss of function by mutation; if, for instance, we wanted a system to function only for a short period.		Our engineered biological systems exist inside replicating machines (i.e., living cells). Machine replication results in spontaneous errors in the genetic information encoding our systems. As engineers, we would like to be able to design systems such that performance in the face of mutation and selection is predictable. Further, we would like to either decrease or increase the susceptibility of the system to loss of function by mutation; if, for instance, we wanted a system to function only for a short period.

-	To begin to solve this problem, we define two aspects of evolutionary stability: ~~(1)~~ [[genetic stability]] ~~and (2) [[performance stability]]. Genetic stability is~~ the stability of the information encoding the system -- the stability of the DNA sequence itself. ~~Performance~~ stability is the capacity of the system to continue to function reliably given changes in the underlying DNA sequence. Note that a system that was genetically stable would by default have performance stability, but not vice-versa.	+	To begin to solve this problem, we define two aspects of evolutionary stability:
		+	#[[genetic stability]]
		+	#*the stability of the information encoding the system -- the stability of the DNA sequence itself.
		+	#[[performance stability]]
		+	#*the capacity of the system to continue to function reliably given changes in the underlying DNA sequence.
		+	Note that a system that was genetically stable would by default have performance stability, but not vice-versa.

Jason R. Kelly at 21:31, 23 May 2005

2005-05-23T21:31:22Z

←Older revision		Revision as of 21:31, 23 May 2005
Line 1:		Line 1:
	Our engineered biological systems exist inside replicating machines (i.e., living cells). Machine replication results in spontaneous errors in the genetic information encoding our systems. As engineers, we would like to be able to design systems such that performance in the face of mutation and selection is predictable. Further, we would like to either decrease or increase the susceptibility of the system to loss of function by mutation; if, for instance, we wanted a system to function only for a short period.		Our engineered biological systems exist inside replicating machines (i.e., living cells). Machine replication results in spontaneous errors in the genetic information encoding our systems. As engineers, we would like to be able to design systems such that performance in the face of mutation and selection is predictable. Further, we would like to either decrease or increase the susceptibility of the system to loss of function by mutation; if, for instance, we wanted a system to function only for a short period.

-	To begin to solve this problem, we define two aspects of evolutionary stability: (1) genetic stability and (2) performance stability. Genetic stability is the stability of the information encoding the system -- the stability of the DNA sequence itself. Performance stability is the capacity of the system to continue to function reliably given changes in the underlying DNA sequence. Note that a system that was genetically stable would by default have performance stability, but not vice-versa.	+	To begin to solve this problem, we define two aspects of evolutionary stability: (1) [[genetic stability]] and (2) [[performance stability]]. Genetic stability is the stability of the information encoding the system -- the stability of the DNA sequence itself. Performance stability is the capacity of the system to continue to function reliably given changes in the underlying DNA sequence. Note that a system that was genetically stable would by default have performance stability, but not vice-versa.

Jason R. Kelly at 21:30, 23 May 2005

2005-05-23T21:30:59Z

New page

Our engineered biological systems exist inside replicating machines (i.e., living cells). Machine replication results in spontaneous errors in the genetic information encoding our systems. As engineers, we would like to be able to design systems such that performance in the face of mutation and selection is predictable. Further, we would like to either decrease or increase the susceptibility of the system to loss of function by mutation; if, for instance, we wanted a system to function only for a short period.

To begin to solve this problem, we define two aspects of evolutionary stability: (1) genetic stability and (2) performance stability. Genetic stability is the stability of the information encoding the system -- the stability of the DNA sequence itself. Performance stability is the capacity of the system to continue to function reliably given changes in the underlying DNA sequence. Note that a system that was genetically stable would by default have performance stability, but not vice-versa.