Experimental Anaesthesiology Antkowiak Lab:Publications

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2017

• Rosenberger P, Drexler B: Entwicklung der anästhesieassoziierten Letalität und Einfluss auf das Outcome. AINS 2017 Jul;52(7-08):486-497. pub med

• Fideler F, Grasshoff C: Anästhesie und Outcome: Einfluss bei Kindern. AINS 2017 Jul;52(7-08):513-523. pub med

• Balk M, Hentschke H, Rudolph U, Antkowiak B, Drexler B: Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices. Scientific Reports 14 June 2017 open access

2016

• Antkowiak B, Rudolph U: New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors. Curr Opin Anaesthesiol. 2016 Aug;29(4):447-53 Journal

• Drexler B, Balk M, Antkowiak B: Synergistic modulation of GABA(A) receptor-mediated synaptic inhibition in cortical networks by allopregnanolone and propofol. Anesthesia & Analgesia, 2016 Journal

• Eckle VS, Balk M, Thiermann H, Antkowiak B, Grasshoff C: Botulinum toxin B increases intrinsic muscle activity in organotypic spinal cord-skeletal muscle co-cultures. Toxicol Lett. 2016 Feb 26;244:167-71 Journal

• Weimer I, Worek F, Seeger T, Thiermann H, Grasshoff C, Antkowiak B, Balk M: Anesthetic actions of thiopental remain largely unaffected during cholinergic overstimulation in cultured cortical networks. Toxicol Lett. 2016 Feb 26;244:129-35 PubMed

• Weimer I, Worek F, Seeger T, Thiermann H, Eckle VS, Grasshoff C, Antkowiak B: Self-regeneration of neuromuscular function following soman and VX poisoning in spinal cord-skeletal muscle cocultures. Toxicol Lett. 2016 Feb 26;244:149-53 PubMed

• Drexler B: Volatile oder intravenöse Anästhetika - Die Eigenschaften bestimmen den klinischen Einsatz, in: Eckart, Jaeger, Möllhoff - Anästhesiologie - 47.Erg.-Lfg. 4/16

2015

• Eckle VS, Rudolph U, Antkowiak B, Grasshoff C: Propofol modulates phasic and tonic GABAergic currents in spinal ventral horn interneurones. British Journal of Anaesthesia 2015; 114(3):491-8. link

• Liebig L, von Ameln-Mayerhofer A, Hentschke H: MDMA modulates spontaneous firing of subthalamic nucleus neurons in vitro. Experimental Brain Research 2015; 233(1):137-47. link

• Antkowiak B: Closing the gap between the molecular and systemic actions of anesthetic agents. Advances in Pharmacology 2015; 72: 229-62. PubMed

2014

• Eckle VS, Drexler B, Grasshoff C, Seeger T, Thiermann H, Antkowiak B: Spinal cord - skeletal muscle cocultures detect muscle-relaxant action of botulinum neurotoxin A. Alternatives to Animal Experimentation (ALTEX). 2014 Aug 14 PubMed

• Kreuzer M, Jordan D, Antkowiak B, Drexler B, Kochs EF, Schneider G: Brain Electrical Activity Obeys Benford’s Law. Anesthesia & Analgesia 118(1): 183–191, 2014 PubMed

2013

• Razik DS, Hawellek DJ, Antkowiak B, Hentschke H. Impairment of GABA transporter GAT-1 terminates cortical recurrent network activity via enhanced phasic inhibition. Front Neural Circuits. 2013 Sep 11;7:141. PubMed

• Drexler B, Thiermann H, Antkowiak B, Grasshoff C. Effects of succinylcholine in an organotypic spinal cord-skeletal muscle coculture of embryonic mice. Chemico-Biological Interactions 2013 July 6. abstract

• Drexler B, Kreuzer M, Jordan D, Antkowiak B, Schneider G. Sevoflurane-induced loss of consciousness is paralleled by a prominent modification of neural activity during cortical down-states. Neurosci Lett. 548: 149 - 54; 2013. abstract

• Eckle VS, Antkowiak B. ALX 1393 inhibits spontaneous network activity by inducing glycinergic tonic currents in the spinal ventral horn. Neuroscience. 2013 Dec 3;253:165-71. PubMed

• Thiel C, Landgrebe K, Knubben E, Nadalin S, Ladurner R, Grasshoff C, Königsrainer A, Schenk M, Thiel K.Contributors to individual quality of life after liver transplantation. Eur J Clin Invest. 2013 Jan;43(1):11-9. PubMed

• Eckle VS, Hauser S, Drexler B, Antkowiak B, Grasshoff C: Opposing Actions of Sevoflurane on GABAergic and Glycinergic Synaptic Inhibition in the Spinal Ventral Horn. PLOS ONE 2013 8(4) e60286 pdf

• Drexler B, Zinser S, Huang S, Poe MM, Rudolph U, Cook JM, Antkowiak B. Enhancing the function of alpha5-subunit-containing GABA(A) receptors promotes action potential firing of neocortical neurons during up-states. Eur J Pharmacol. 2013 703 (1-3): 18 - 24 abstract

2012

• Drexler B, Grasshoff C. Ist tiefe Narkose gefährlich? Der Anaesthesist 61(8): 678-85; 2012 abstract

2011

• Hentschke H, Stüttgen MC. Computation of measures of effect size for neuroscience data sets. Eur J Neurosci 34:1887-1894, 2011 PubMed

• Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011;80:900-10. PubMed

• Drexler B, Zinser S, Seeger T, Thiermann H, Antkowiak B, Grasshoff C: Anaesthetic potency of diazepam is resistant to cholinergic overstimulation. Toxicol Lett. 2011 Sep 25;206(1):84-8 PubMed

• Bitzinger D, Drexler B, Francis R, Hubrath M, Larmann J, Nau C, Redel A, Roewer N, Stehr S, Thal S, Theilmeier T, Urban B: Der Wissenschaftliche Arbeitskreis „Wissenschaftlicher Nachwuchs“ der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin. AINS (Anästhesiol Intensivmed Notfallmed Schmerzther) 2011; 46(6): 444-447 abtract

• Drexler B, Seeger T, Grasshoff C, Thiermann H, Antkowiak B: Long-term evaluation of organophosphate toxicity and antidotal therapy in co-cultures of spinal cord and muscle tissue. Toxicol Lett. 2011 Sep 25;206(1):89-93 PubMed

• Drexler B, Antkowiak B, Engin E, Rudolph U: Identification and Characterization of Anesthetic Targets by Mouse Molecular Genetics Approaches. Canadian Journal of Anesthesia 58: 178-190 PubMed

• Ostermeier A, Danz S, Unertl K, Grasshoff C: Risking or saving the patient's neck - relocation of an odontoid fracture by direct laryngoscopy and manual in-line stabilization during resuscitation. Resuscitation 2011 Jan;82(1):137-8. Epub 2010 Nov 2 PubMed

2010

• Drexler B, Hentschke H, Antkowiak B, Grasshoff C: Organotypic cultures as tools for testing neuroactive drugs - link between in-vitro and in-vivo experiments. Current Medicinal Chemistry, 17(36): 4538-4550 PubMed

• Schwarz C, Hentschke H, Butovas S, Haiss F, Stüttgen MC, Gerdjikov TV, Bergner CG, Waiblinger C: The head-fixed behaving rat - procedures and pitfalls. Somatosens Mot Res. 2010;27(4):131-48. Epub 2010 Oct 18. PubMed

• Kreuzer M, Hentschke H, Antkowiak B, Schwarz C, Kochs EF, Schneider G: Cross-Approximate Entropy of cortical local field potentials quantifies effects of anesthesia - a pilot study in rats. BMC Neurosci 11(1):122, 2010 PubMed

• Butovas S, Rudolph U, Jurd R, Schwarz C, Antkowiak B: Activity patterns in the prefrontal cortex and hippocampus during and after awakening from etomidate anesthesia. Anesthesiology. 2010 Jul; 113(1):48-57 PubMed

• Drexler B, Zinser S, Hentschke H, Antkowiak B: Diazepam Decreases Action Potential Firing of Neocortical Neurons via Two Distinct Mechanisms. Anesthesia & Analgesia 111:1394-1399; 2010 PubMed

• Drexler B, Antkowiak B, Thiermann H, Seeger T, Grasshoff C: Interactions between atropine and etomidate in cortical and spinal networks during cholinergic crisis. Toxicology Letters 198(3): 342-7, 2010 PubMed

• Grasshoff C, Antkowiak B: Organotypic cultures of spinal cord ventral horn are valuable tools for investigating immobility-related mechanisms in vitro. Anesth Analg. 2010 Feb;110(2):638 PubMed

• Drexler B, Antkowiak B, Thiermann H, Grasshoff C: Atropine increases sevoflurane potency in cortical but not spinal networks during cholinergic overstimulation. Toxicology 268: 98 - 103; 2010 PubMed

• Thiermann H, Seeger T, Gonder S, Herkert N, Antkowiak B, Zilker T, Eyer F, Worek F: Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds. Chem Biol Interact. 2010 Sep 6; 187(1-3):265-9. Epub 2009 Dec 26 PubMed

• Schirner A, Unertl K, Grasshoff C: Dissimulation in patients with myotonic dystrophy. Eur J Anaesthesiol. 2010 Sep;27(9):842-3. Epub 2009 Nov 26 PubMed

2009

• Hentschke H, Benkwitz C, Banks MI, Perkins MG, Homanics GE, Pearce RA: Altered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit. J Neurophysiol. 2009 Dec;102(6):3643-55. Epub 2009 Oct 21 PubMed

• Drexler B, Jurd R, Rudolph U, Antkowiak B: Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors. Neuropharmacology 2009 57(4) 446-455 PubMed and F1000

2008

• Grasshoff C, Netzhammer N, Schweizer J, Antkowiak B, Hentschke H: Depression of spinal network activity by thiopental: Shift from phasic to tonic GABA(A) receptor-mediated inhibition. Neuropharmacology 2008 Oct 55(5): 793-802 PubMed

• Zeller A, Jurd R, Lambert S, Arras M, Drexler B, Grasshoff C, Antkowiak B, Rudolph U: Inhibitory ligand-gated ion channels as substrates for general anesthetic actions. Modern anesthetics in: Handbook of Experimental Pharmacology (Vol 182), Schüttler J, Schwilden H (eds.), 2008, XVI PubMed

2007

• Holt C, Zwölfer H: Life history and behaviour of Terellia longicauda (Meigen), a highly specialised tephritid of the woolly thistle, Cirsium eriophorum. Studia dipterologica 14 (2007) Heft 2 Abstract

• Hentschke H, Perkins MG, Pearce RA, Banks MI: Muscarinic blockade weakens interaction of gamma with theta rhythms in mouse hippocampus. European Journal of Neuroscience. 2007 Sep 26(6): 1642-56 PubMed

• Grasshoff C, Jurd R, Rudolph U, Antkowiak B: Modulation of presynaptic β3-containing GABAA receptors limits the immobilizing actions of GABAergic anesthetics. Mol Pharmacol. 2007 Sep 72(3): 780-7 PubMed

• Perouansky M, Hentschke H, Perkins M, Pearce RA: Amnesic concentrations of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N) and isoflurane alter hippocampal theta oscillations in vivo. Anesthesiology. 2007 Jun;106(6):1168-76 PubMed

• Grasshoff C, Drexler B, Hentschke H, Thiermann H, Antkowiak B: Cholinergic modulation of sevoflurane potency in cortical and spinal networks in vitro. Anesthesiology. 2007 Jun;106(6):1147-55 PubMed

• Grasshoff C, Thiermann H, Antkowiak B: Anaesthesia in patients suffering from organophosphorus intoxication - interactions between general anaesthetics and acetylcholine in cortical networks in vitro. Toxicology. 2007 Apr 20;233(1-3):214-22. Epub 2006 Sep 8 PubMed

• Grasshoff C, Drexler B, Antkowiak B: Effects of cholinergic overstimulation on isoflurane potency and efficacy in cortical and spinal networks. Toxicology. 2007 Jan 18;229(3):206-13. Epub 2006 Dec 4 PubMed

2006

• Grasshoff C, Antkowiak B: Effects of isoflurane and enflurane on GABAA and glycine receptors contribute equally to depressant actions on spinal ventral horn neurones in rats. Br J Anaesth. 2006 Nov;97(5):687-94 PubMed

• Drexler B, Jurd R, Rudolph U, Antkowiak B: Dual actions of enflurane on postsynaptic currents abolished by the γ-aminobutyric acid type A receptor β3(N265) point mutation. Anesthesiology 2006, 105(2):297-304 PubMed and F1000

• Hentschke H, Haiss F, Schwarz C: Central signals rapidly switch tactile processing in rat barrel cortex during whisker movements. Cerebral Cortex, 2006 Aug;16(8):1142-56 PubMed

• Grasshoff C, Drexler B, Rudolph U, Antkowiak B: Anaesthetic drugs: Linking molecular actions to clinical effects. Current Pharmaceutical Design. 2006, 12(28): 3665-679 PubMed

• Drexler B, Grasshoff C, Rudolph U, Unertl K, Antkowiak B: The GABA(A) receptor family. Possibilities for the development of better anesthetics. Anaesthesist. 2006 Mar;55(3):287-95 PubMed

2005

• Jurd R, Arras M, Zeller A, Lambert S, Lazaris A, Crestani F, Drexler B, Siegwart R, Vogt KE, Antkowiak B, Rudolph U: β3-containing GABAA receptors mediate the immobilizing and, in part, the hypnotic actions of etomidate and propofol. International Congress Series 1283 (2005) 143-148 ScienceDirect

• Antkowiak B: 'The anesthetic cascade' - Fact or Fiction? (Letter), Anesthesiology. 2005 Oct;103(4):904-5 PubMed

• Grasshoff C, Rudolph U, Antkowiak B: Molecular and systemic mechanisms of general anaesthesia: the 'multi-site and multiple mechanisms' concept. Current Opinion in Anaesthesiology. 2005 Aug; 18(4):386-91 PubMed

• Grasshoff C, Gillessen T: Effects of Propofol on N-Methyl-D-Aspartate receptor-mediated calcium increase in cultured rat cerebrocortical neurons. European Journal of Anaesthesiology. 2005 Jun;22(6):467-70 PubMed

• Grasshoff C, Gillessen T, Wagner E, Thiermann H, Szinicz L: Ketamine reduces cholinergic modulated GABA release from rat striatal slices. Toxicology letters. 2005 Apr 28;156(3):361-7 PubMed

• Grasshoff C, Herrera-Marschitz M, Goiny M, Kretschmer BD. Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis. Amino Acids. 2005 Mar;28(2):145-8 PubMed

• Hentschke H, Schwarz C, Antkowiak B: Neocortex is the major target of sedative concentrations of volatile anesthetics: strong depression of firing rates and increase of GABAA receptor-mediated inhibition. European Journal of Neuroscience. 2005 Jan;21(1):93-102 PubMed

• Drexler B, Roether CL, Jurd R, Rudolph U, Antkowiak B: Opposing actions of etomidate on cortical theta ascillations are mediated by different γ-aminobutyric acid type A receptor subtypes. Anesthesiology 102(2): 346-352; 2005 PubMed

2004

• Grasshoff C, Antkowiak B: Propofol and Sevoflurane Depress Spinal Neurons In Vitro via Different Molecular Targets. Anesthesiology. 101(5):1167-1176, November 2004 PubMed

• Rudolph U, Antkowiak B: Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci. 2004 Sep;5(9):709-20. Review PubMed

2003

• Grasshoff C, Gillessen T, Thiermann H, Wagner E, Szinicz L: The effect of acetylcholinesterase-inhibition on depolarization-induced GABA release from rat striatal slices. Toxicology 2003; 184: 149-56 PubMed

• Heck D, Borst A, Antkowiak B: Passive spatial and temporal integration of excitatory synaptic inputs in cerebellar Purkinje cells of young rats. Neuroscience Letters 2003; 341: 79-83 PubMed

• Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt KE, Ledermann B, Antkowiak B, Rudolph U: General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta 3 subunit. FASEB Journal 2003; 17: 250-2 PubMed

2002

• Antkowiak B: In vitro networks: cortical mechanisms of anaesthetic action. British Journal of Anaesthesia 2002; 89: 102-11 PubMed

• Benkwitz C, Roewer N, Antkowiak B: Anesthetic action on neuronal network activity in hippocampus: Electrophysiology and Ca-Imaging, Molecular and basic mechanisms of anesthesia. Edited by Urban BW, Barann M. Lengerich, Pabst, 2002, pp 355-62 ISBN 3-936142-41-6

• Gillessen T, Grasshoff C, Szinicz L: Mitochondrial permeability transition can be directly monitored in living neurons. Biomed.Pharmacother. 2002; 56: 186-93 PubMed

• Grasshoff C, Antkowiak B: Effects of volatile anesthetics on action potential firing of spinal neurons in organotypic slice cultures, Molecular and basic mechanisms of anesthesia. Edited by Urban BW, Barann M. Lengerich, Pabst, 2002, pp 363-9 ISBN 3-936142-41-6

• Grasshoff C, Gillessen T: The effect of propofol on increased superoxide concentration in cultured rat cerebrocortical neurons after stimulation of N-methyl-d-aspartate receptors. Anesth.Analg. 2002; 95: 920-2 PubMed

2001

• Antkowiak B: Cerebral effects of volatile anaesthetics - What do we really know? Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie 2001; 36: 365-7 PubMed

• Antkowiak B: How do general anaesthetics work? Naturwissenschaften 2001; 88: 201-13 PubMed

• Grasshoff C, Szinicz L, Sohns T: Diagnose und Therapie von Gesundheitsschäden durch chemische Waffen im Rettungsdienst. Notfallvorsorge 2, 23-26. 2001

• Grasshoff C, Thiermann H, Gillessen T, Zilker T, Szinicz L: Internal standard high-performance liquid chromatography method for the determination of obidoxime in urine of organophosphate-poisoned patients. J.Chromatogr.B Biomed.Sci.Appl. 2001; 753: 203-8 ScienceDirect

2000

• Antkowiak B, Kirschfeld K: Neural mechanisms of anaesthesia. Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie 2000; 35: 731-43 PubMed

• Antkowiak B, Hentschke H: Effects of benzodiazepines and general anaesthetics on the GABA(A) receptor: Where are the differences? Anästhesiologie Intensivmedizin Notfallmedizin Schmerztherapie 2000; 35: 593-5 PubMed

1999

• Antkowiak B: Different actions of general anaesthetics on the firing patterns of neocortical neurons mediated by the GABAA receptor. Anesthesiology 1999; 91: 500-11 PubMed

• Antkowiak B, Hentschke H: Zentralnervöse Wirkungen von Schlaf- und Narkosemitteln, Jahrbuch der Max-Planck-Gesellschaft 1999. Edited by Generalverwaltung der Max-Planck-Gesellschaft. Göttingen, Verlag Vandenhoeck & Ruprecht, 1999, pp 227-37

• Hentschke H, Antkowiak B: NMDA receptor-mediated changes of spontaneous activity patterns in thalamocortical slice cultures. Brain Research 1999; 830: 123-37 PubMed

1998

• Antkowiak B, Helfrich-Förster C: Effects of small concentrations of volatile anesthetics on action potential firing of neocortical neurons in vitro. Anesthesiology 1998; 88: 1592-602 PubMed

• Engelmann W, Antkowiak B: Ultradian Rhythms in Desmodium. Chronobiology International 1998; 15: 293-307 PubMed

1997

• Antkowiak B, Hentschke H: Cellular mechanisms of gamma rhythms in rat neocortical brain slices probed by the volatile anaesthetic isoflurane. Neuroscience Letters 1997; 231: 87-90 PubMed

• Antkowiak B, Hentschke H, Kirschfeld K: Effects of volatile anaesthetics on spontaneous action potential firing of cerebellar Purkinje cells in vitro do not follow the Meyer-Overton rule. British Journal of Anaesthesia 1997; 79: 617-24 PubMed

• Antkowiak B, Heck D: Effects of the volatile anesthetic enflurane on spontaneous discharge rate and GABAA-mediated inhibition of Purkinje cells in rat cerebellar slices. Journal of Neurophysiology 1997; 77: 2525-38 PubMed

• Felisberti F, Antkowiak B, Kirschfeld K: Effects of volatile anaesthetics on the membrane potential and ion channels of cultured neocortical astrocytes. Brain Research 1997; 766: 56-65 PubMed

1995

• Antkowiak B, Engelmann W: Oscillations of apoplasmic K+ and H+ activities in Desmodium motorium (Houtt.) Merril. pulvini in relation to the membrane potential of motor cells and leaflet movements. Planta 1995; 196: 350-6 Abstract

• Kirschfeld K, Antkowiak B: Die neuronale Basis des Zustandes der Narkose: Probleme, Ergebnisse, Forschungstrends. Neuroforum 1995; 3: 5-16

1994

• Rinast KA, Antkowiak B, Brinkmann K: Systems analysis of yeast glycolysis using perturbations of external pH: physiological parameters, non-parametric analysis, and general properties of the system dynamics. Biosystems 1994; 32: 211-21 PubMed