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Overexpression and mutant analyses indicate that all the circadian regulated PRRs play a role in the regulation of the circadian clock in Arabidopsis [32, 33]. Furthermore, experiments performed in rice, wheat and barley show that the PRRs also play a role in the regulation of the circadian rhythms and flowering time in these species [34-39]. The expression of all PRRs is clock regulated with each peaking at a different time of the day or night [18]. As indicated above, recent results also suggest that post-translational regulation plays a key role in the function of these proteins [23-25, 40]. Genetic analyses have shown that PRR7, PRR9 and PRR5 play partially redundant functions [41-44]. PRRs share two conserved protein domains. The pseudo-receiver domain (PR) shares homology with the receiver domains found in response regulators involved in the two-component signaling pathways found in bacteria and plants [45, 46]. However, it lacks the specific aspartate residue that becomes phosphorylated in canonical receiver domains and in vitro experiments suggest that unlike other plant response regulators it cannot be phosphorylated by sensor histidine kinases [47, 48]. The CCT domain (CONSTANS,CONSTANTS-LIKE, TOC1) contains a putative nuclear localization signal and shares some homology with the DNA binding domain of yeast HEME activator protein 2 (HAP2), which is a subunit of the HAP2/HAP3/HAP5 trimeric complex that binds to CCAAT boxes in eukaryotic promoters [49]. However, the DNA binding capacity of CCT domains has not been reported. Recent work indicates that PRR3 is involved in the regulation of TOC1 stability [50], which represents the first report of the biochemical function of a PRRs (Figure 2). The biochemical function of the other PRRs remains to be elucidated.
Overexpression and mutant analyses indicate that all the circadian regulated PRRs play a role in the regulation of the circadian clock in Arabidopsis [32, 33]. Furthermore, experiments performed in rice, wheat and barley show that the PRRs also play a role in the regulation of the circadian rhythms and flowering time in these species [34-39]. The expression of all PRRs is clock regulated with each peaking at a different time of the day or night [18]. As indicated above, recent results also suggest that post-translational regulation plays a key role in the function of these proteins [23-25, 40]. Genetic analyses have shown that PRR7, PRR9 and PRR5 play partially redundant functions [41-44]. PRRs share two conserved protein domains. The pseudo-receiver domain (PR) shares homology with the receiver domains found in response regulators involved in the two-component signaling pathways found in bacteria and plants [45, 46]. However, it lacks the specific aspartate residue that becomes phosphorylated in canonical receiver domains and in vitro experiments suggest that unlike other plant response regulators it cannot be phosphorylated by sensor histidine kinases [47, 48]. The CCT domain (CONSTANS,CONSTANTS-LIKE, TOC1) contains a putative nuclear localization signal and shares some homology with the DNA binding domain of yeast HEME activator protein 2 (HAP2), which is a subunit of the HAP2/HAP3/HAP5 trimeric complex that binds to CCAAT boxes in eukaryotic promoters [49]. However, the DNA binding capacity of CCT domains has not been reported. Recent work indicates that PRR3 is involved in the regulation of TOC1 stability [50], which represents the first report of the biochemical function of a PRRs (Figure 2). The biochemical function of the other PRRs remains to be elucidated.
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<h2><font style="color:#006400;">Bibliography</font></h2>
 +
 +
'''1.''' Ouyang, Y., Andersson, C.R., Kondo, T., Golden, S.S., and Johnson, C.H. (1998). Resonating circadian clocks enhance fitness in cyanobacteria. Proc Natl Acad Sci U S A 95, 8660-8664.
 +
 +
'''2.''' Woelfle, M.A., Ouyang, Y., Phanvijhitsiri, K., and Johnson, C.H. (2004). The adaptive value of circadian clocks: an experimental assessment in cyanobacteria. Curr Biol 14, 1481-1486.
 +
 +
'''3.''' Dodd, A.N., Salathia, N., Hall, A., Kevei, E., Toth, R., Nagy, F., Hibberd, J.M., Millar, A.J., and Webb, A.A. (2005). Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage. Science 309, 630-633.
 +
 +
'''4.''' Hastings, M.H., Reddy, A.B., and Maywood, E.S. (2003). A clockwork web: circadian timing in brain and periphery, in health and disease. Nat Rev Neurosci 4, 649-661.
 +
 +
'''5.''' Yanovsky, M.J., and Kay, S.A. (2003). Living by the calendar: how plants know when to flower. Nat Rev Mol Cell Biol 4, 265-275.
 +
 +
'''6.''' Imaizumi, T., and Kay, S.A. (2006). Photoperiodic control of flowering: not only by coincidence. Trends Plant Sci 11, 550-558.
 +
 +
'''7.''' Dowson-Day, M.J., and Millar, A.J. (1999). Circadian dysfunction causes aberrant hypocotyl elongation patterns in Arabidopsis. Plant J 17, 63-71.
 +
 +
'''8.''' Hennessey, T.L., and Field, C.B. (1991). Circadian Rhythms in Photosynthesis : Oscillations in Carbon Assimilation and Stomatal Conductance under Constant Conditions. Plant Physiol 96, 831-836.
 +
 +
'''9.''' Harmer, S.L., Hogenesch, J.B., Straume, M., Chang, H.S., Han, B., Zhu, T., Wang, X., Kreps, J.A., and Kay, S.A. (2000). Orchestrated transcription of key pathways in Arabidopsis by the circadian clock. Science 290, 2110-2113.
 +
 +
'''10.''' Schaffer, R., Landgraf, J., Accerbi, M., Simon, V., Larson, M., and Wisman, E. (2001). Microarray analysis of diurnal and circadian-regulated genes in Arabidopsis. Plant Cell 13, 113-123.
 +
 +
'''11.''' Michael, T.P., and McClung, C.R. (2003). Enhancer trapping reveals widespread circadian clock transcriptional control in Arabidopsis. Plant Physiol 132, 629-639.
 +
 +
'''12.''' Alabadi, D., Oyama, T., Yanovsky, M.J., Harmon, F.G., Mas, P., and Kay, S.A. (2001). Reciprocal regulation between TOC1 and LHY/CCA1 within the Arabidopsis circadian clock. Science 293, 880-883.
 +
 +
'''13.''' Green, R.M., and Tobin, E.M. (1999). Loss of the circadian clock-associated protein 1 in Arabidopsis results in altered clock-regulated gene expression. Proc Natl Acad Sci U S A 96, 4176-4179.
 +
 +
'''14.''' Alabadi, D., Yanovsky, M.J., Mas, P., Harmer, S.L., and Kay, S.A. (2002). Critical role for CCA1 and LHY in maintaining circadian rhythmicity in Arabidopsis. Curr Biol 12, 757-761.
 +
 +
'''15.''' Mizoguchi, T., Wheatley, K., Hanzawa, Y., Wright, L., Mizoguchi, M., Song, H.R., Carre, I.A., and Coupland, G. (2002). LHY and CCA1 are partially redundant genes required to maintain circadian rhythms in Arabidopsis. Dev Cell 2, 629-641.
 +
 +
'''16.''' Locke, J.C., Millar, A.J., and Turner, M.S. (2005). Modelling genetic networks with noisy and varied experimental data: the circadian clock in Arabidopsis thaliana. J Theor Biol 234, 383-393.
 +
 +
'''17.''' Somers, D.E., Webb, A.A., Pearson, M., and Kay, S.A. (1998). The short-period mutant, toc1-1, alters circadian clock regulation of multiple outputs throughout development in Arabidopsis thaliana. Development 125, 485-494.
 +
 +
'''18.''' Matsushika, A., Makino, S., Kojima, M., and Mizuno, T. (2000). Circadian waves of expression of the APRR1/TOC1 family of pseudo-response regulators in Arabidopsis thaliana: insight into the plant circadian clock. Plant Cell Physiol 41, 1002-1012.
 +
 +
'''19.''' Hazen, S.P., Schultz, T.F., Pruneda-Paz, J.L., Borevitz, J.O., Ecker, J.R., and Kay, S.A. (2005). LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms. Proc Natl Acad Sci U S A 102, 10387-10392.
 +
 +
'''20.''' Schaffer, R., Ramsay, N., Samach, A., Corden, S., Putterill, J., Carre, I.A., and Coupland, G. (1998). The late elongated hypocotyl mutation of Arabidopsis disrupts circadian rhythms and the photoperiodic control of flowering. Cell 93, 1219-1229.
 +
 +
'''21.''' Doyle, M.R., Davis, S.J., Bastow, R.M., McWatters, H.G., Kozma-Bognar, L., Nagy, F., Millar, A.J., and Amasino, R.M. (2002). The ELF4 gene controls circadian rhythms and flowering time in Arabidopsis thaliana. Nature 419, 74-77.
 +
 +
'''22.''' Kikis, E.A., Khanna, R., and Quail, P.H. (2005). ELF4 is a phytochrome-regulated component of a negative-feedback loop involving the central oscillator components CCA1 and LHY. Plant J 44, 300-313.
 +
 +
'''23.''' Mas, P., Kim, W.Y., Somers, D.E., and Kay, S.A. (2003). Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana. Nature 426, 567-570.
 +
 +
'''24.''' Kiba, T., Henriques, R., Sakakibara, H., and Chua, N.H. (2007). Targeted Degradation of PSEUDO-RESPONSE REGULATOR5 by an SCFZTL Complex Regulates Clock Function and Photomorphogenesis in Arabidopsis thaliana. Plant Cell 19, 2516-2530.
 +
 +
'''25.''' Ito, S., Nakamichi, N., Kiba, T., Yamashino, T., and Mizuno, T. (2007). Rhythmic and Light-Inducible Appearance of Clock-Associated Pseudo-Response Regulator Protein PRR9 Through Programmed Degradation in the Dark in Arabidopsis thaliana. Plant Cell Physiol., pcm122.
 +
 +
'''26.''' Schultz, T.F., Kiyosue, T., Yanovsky, M., Wada, M., and Kay, S.A. (2001). A role for LKP2 in the circadian clock of Arabidopsis. Plant Cell 13, 2659-2670.
 +
 +
'''27.''' Nelson, D.C., Lasswell, J., Rogg, L.E., Cohen, M.A., and Bartel, B. (2000). FKF1, a clock-controlled gene that regulates the transition to flowering in Arabidopsis. Cell 101, 331-340.
 +
 +
'''28.''' Imaizumi, T., Schultz, T.F., Harmon, F.G., Ho, L.A., and Kay, S.A. (2005). FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis. Science 309, 293-297.
 +
 +
'''29.''' Imaizumi, T., Tran, H.G., Swartz, T.E., Briggs, W.R., and Kay, S.A. (2003). FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis. Nature 426, 302-306.
 +
 +
'''30.''' Sawa, M., Nusinow, D.A., Kay, S.A., and Imaizumi, T. (2007). FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis. Science 318, 261-265.
 +
 +
'''31.''' Kim, W.Y., Fujiwara, S., Suh, S.S., Kim, J., Kim, Y., Han, L.Q., David, K., Putterill, J., Nam, H.G., and Somers, D.E. (2007). ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light. Nature 449, 356.
 +
 +
'''32.''' Mizuno, T. (2004). Plant response regulators implicated in signal transduction and circadian rhythm. Curr Opin Plant Biol 7, 499-505.
 +
 +
'''33.''' Mizuno, T. (2005). Two-component phosphorelay signal transduction systems in plants: from hormone responses to circadian rhythms. Biosci Biotechnol Biochem 69, 2263-2276.
 +
 +
'''34.''' Turner, A., Beales, J., Faure, S., Dunford, R.P., and Laurie, D.A. (2005). The pseudo-response regulator Ppd-H1 provides adaptation to photoperiod in barley. Science 310, 1031-1034.
 +
 +
'''35.''' Beales, J., Turner, A., GriYths, S., Snape, J.W., and Laurie, D.A. (2007). A Pseudo-Response Regulator is misexpressed in the photoperiod insensitive Ppd-D1a mutant of wheat (Triticum aestivum L.). Theoretical and Applied Genetics 115, 721-733.
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'''36.''' Murakami, M., Tago, Y., Yamashino, T., and Mizuno, T. (2007). Comparative Overviews of Clock-Associated Genes of Arabidopsis thaliana and Oryza sativa. Plant Cell Physiol. 48, 110-121.
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'''37.''' Murakami, M., Tago, Y., Yamashino, T., and Mizuno, T. (2007). Characterization of the rice circadian clock-associated pseudo-response regulators in Arabidopsis thaliana. Bioscience Biotechnology and Biochemistry 71, 1107-1110.
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'''38.''' Murakami, M., Matsushika, A., Ashikari, M., Yamashino, T., and Mizuno, T. (2005). Circadian-associated rice pseudo response regulators (OsPRRs): insight into the control of flowering time. Biosci Biotechnol Biochem 69, 410-414.
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'''39.''' Tago, Y., Murakami, M., Yamashino, T., and Mizuno, T. (2005). Pseudo response regulators implicated in circadian rhythm of rice: Characterization of OsPRR1 orthlogous to the Arabidopsis clock-component TOC1. Plant and Cell Physiology 46, S98-S98.
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'''40.''' Farre, E.M., and Kay, S.A. (2007). PRR7 protein levels are regulated by light and the circadian clock in Arabidopsis. Plant J 52, 548-560.
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'''41.''' Nakamichi, N., Kita, M., Ito, S., Sato, E., Yamashino, T., and Mizuno, T. (2005). The Arabidopsis pseudo-response regulators, PRR5 and PRR7, coordinately play essential roles for circadian clock function. Plant Cell Physiol 46, 609-619.
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'''42.''' Nakamichi, N., Kita, M., Ito, S., Yamashino, T., and Mizuno, T. (2005). PSEUDO-RESPONSE REGULATORS, PRR9, PRR7 and PRR5, together play essential roles close to the circadian clock of Arabidopsis thaliana. Plant Cell Physiol 46, 686-698.
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'''43.''' Salome, P.A., and McClung, C.R. (2005). PSEUDO-RESPONSE REGULATOR 7 and 9 are partially redundant genes essential for the temperature responsiveness of the Arabidopsis circadian clock. Plant Cell 17, 791-803.
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'''44.''' Farre, E.M., Harmer, S.L., Harmon, F.G., Yanovsky, M.J., and Kay, S.A. (2005). Overlapping and distinct roles of PRR7 and PRR9 in the Arabidopsis circadian clock. Curr Biol 15, 47-54.
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'''45.''' Oka, A., Sakai, H., and Iwakoshi, S. (2002). His-Asp phosphorelay signal transduction in higher plants: receptors and response regulators for cytokinin signaling in Arabidopsis thaliana. Genes & Genetic Systems 77, 383-391.
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'''46.''' Hwang, I., and Sheen, J. (2002). Two-component circuitry in Arabidopsis cytokinin signal transduction. Developmental Biology 247, 484-484.
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'''47.''' Strayer, C., Oyama, T., Schultz, T.F., Raman, R., Somers, D.E., Mas, P., Panda, S., Kreps, J.A., and Kay, S.A. (2000). Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog. Science 289, 768-771.
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'''48.''' Makino, S., Kiba, T., Imamura, A., Hanaki, N., Nakamura, A., Suzuki, T., Taniguchi, M., Ueguchi, C., Sugiyama, T., and Mizuno, T. (2000). Genes encoding pseudo-response regulators: insight into His-to-Asp phosphorelay and circadian rhythm in Arabidopsis thaliana. Plant Cell Physiol 41, 791-803.
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'''49.''' Wenkel, S., Turck, F., Singer, K., Gissot, L., Le Gourrierec, J., Samach, A., and Coupland, G. (2006). CONSTANS and the CCAAT box binding complex share a functionally important domain and interact to regulate flowering of Arabidopsis. Plant Cell 18, 2971-2984.
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'''50.''' Para, A., Farre, E.M., Imaizumi, T., Pruneda-Paz, J.L., Harmon, F.G., and Kay, S.A. (in press). PRR3 is a vascular regulator of TOC1 stability in the Arabidopsis circadian clock. Plant Cell.

Revision as of 16:50, 22 September 2008

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Background


Circadian clocks have evolved to provide an adaptive advantage to most organisms that live under alternating cycles of light and darkness [1-3]. The clock provides a mechanism whereby physiological and behavioral processes can be parsed out into the appropriate time of day or night. Furthermore, the evolution of a true oscillator, rather than just a light-responsive sand-timer, enables organisms to predict the alterations that occur in relative proportion to day and night throughout the year in most clines. In mammals, many aspects of behavior and physiology are regulated by endogenous circadian clocks and are subject to daily oscillations [4]. In higher plants, the circadian clock regulates many key physiological processes, ranging from flowering time [5, 6] and growth [7] to stomatal opening and CO2 assimilation [8]. Moreover, in Arabidopsis thaliana the expression of at least 6% of the transcriptome is regulated by the circadian clock [9-11], and recent findings show that the matching of internal and external cycles optimizes growth and survival [3].

Figure 1

Circadian systems can be thought of consisting of 3 parts (Figure 1). The imput pathways are involved in the entrainment or reprograming of the central oscillator which is the core of the circadian system. In turn this molecular self-sustained oscillator regulates the different physiological processes by regulating output pathways.

Although circadian clocks in different species utilize distinct protein motifs for the positive and negative limbs of the clock, the same general pattern of regulation is maintained: transcriptional regulatory loops in combination with post-translational regulation. The first regulatory feedback loop described for Arabidopsis consisted of the repression by the morning expressed CCA1 (CIRCADIAN CLOCK ASSOCIATED 1) and LHY (LATE ELONGATED HYPOCOTYL) of the evening expressed TOC1 (TIMING OF CAB EXPRESSION). In turn, TOC1 has been shown to be necessary for CCA1 and LHY activation [12] (Figure 1). Genetic analysis has demonstrated that CCA1 and LHY have partial redundant functions [13-15] [16]. TOC1 was identified as a circadian mutant in Arabidopsis that exhibited a short period phenotype for multiple outputs [17]. TOC1 belongs to the multigene family of circadian regulated PSEUDO-RESPONSE REGULATORS (PRR), which, in Arabidopsis consists of four other members: PRR3, PRR5, PRR7, PRR9 [18]. In addition to TOC1, there are several other evening expressed genes that are necessary for the morning expression of CCA1 and LHY. These include the putative MYB transcription factor LUX (LUX ARRYTHMO)[19], as well as ELF3 and ELF4 (EARLY FLOWERING 3, 4) [20-22](Figure 2).

Figure 2

Recent results have shown that post-translational regulation of protein levels plays a key role in the control of the plant circadian clock. The F-box protein ZEITLUPE (ZTL) is involved in the degradation of both TOC1 and PRR5 but not PRR9 and PRR7 [23-25] (Figure 1). LKP2 (LOV KELCH PROTEIN 2) is a homologue of ZTL whose arrhythmic overexpression phenotype indicates a key role in regulating circadian rhythms [26]. This ZTL family of F-box proteins that also includes FKF1 (FLAVIN BINDING, KELCH REPEAT, F-BOX 1), a protein involved in the regulation of flowering time [27-29], contain a LOV/PAS domain that mediates blue light dependent protein-protein interactions [30, 31] (Figure 2).

Overexpression and mutant analyses indicate that all the circadian regulated PRRs play a role in the regulation of the circadian clock in Arabidopsis [32, 33]. Furthermore, experiments performed in rice, wheat and barley show that the PRRs also play a role in the regulation of the circadian rhythms and flowering time in these species [34-39]. The expression of all PRRs is clock regulated with each peaking at a different time of the day or night [18]. As indicated above, recent results also suggest that post-translational regulation plays a key role in the function of these proteins [23-25, 40]. Genetic analyses have shown that PRR7, PRR9 and PRR5 play partially redundant functions [41-44]. PRRs share two conserved protein domains. The pseudo-receiver domain (PR) shares homology with the receiver domains found in response regulators involved in the two-component signaling pathways found in bacteria and plants [45, 46]. However, it lacks the specific aspartate residue that becomes phosphorylated in canonical receiver domains and in vitro experiments suggest that unlike other plant response regulators it cannot be phosphorylated by sensor histidine kinases [47, 48]. The CCT domain (CONSTANS,CONSTANTS-LIKE, TOC1) contains a putative nuclear localization signal and shares some homology with the DNA binding domain of yeast HEME activator protein 2 (HAP2), which is a subunit of the HAP2/HAP3/HAP5 trimeric complex that binds to CCAAT boxes in eukaryotic promoters [49]. However, the DNA binding capacity of CCT domains has not been reported. Recent work indicates that PRR3 is involved in the regulation of TOC1 stability [50], which represents the first report of the biochemical function of a PRRs (Figure 2). The biochemical function of the other PRRs remains to be elucidated.


Bibliography

1. Ouyang, Y., Andersson, C.R., Kondo, T., Golden, S.S., and Johnson, C.H. (1998). Resonating circadian clocks enhance fitness in cyanobacteria. Proc Natl Acad Sci U S A 95, 8660-8664.

2. Woelfle, M.A., Ouyang, Y., Phanvijhitsiri, K., and Johnson, C.H. (2004). The adaptive value of circadian clocks: an experimental assessment in cyanobacteria. Curr Biol 14, 1481-1486.

3. Dodd, A.N., Salathia, N., Hall, A., Kevei, E., Toth, R., Nagy, F., Hibberd, J.M., Millar, A.J., and Webb, A.A. (2005). Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage. Science 309, 630-633.

4. Hastings, M.H., Reddy, A.B., and Maywood, E.S. (2003). A clockwork web: circadian timing in brain and periphery, in health and disease. Nat Rev Neurosci 4, 649-661.

5. Yanovsky, M.J., and Kay, S.A. (2003). Living by the calendar: how plants know when to flower. Nat Rev Mol Cell Biol 4, 265-275.

6. Imaizumi, T., and Kay, S.A. (2006). Photoperiodic control of flowering: not only by coincidence. Trends Plant Sci 11, 550-558.

7. Dowson-Day, M.J., and Millar, A.J. (1999). Circadian dysfunction causes aberrant hypocotyl elongation patterns in Arabidopsis. Plant J 17, 63-71.

8. Hennessey, T.L., and Field, C.B. (1991). Circadian Rhythms in Photosynthesis : Oscillations in Carbon Assimilation and Stomatal Conductance under Constant Conditions. Plant Physiol 96, 831-836.

9. Harmer, S.L., Hogenesch, J.B., Straume, M., Chang, H.S., Han, B., Zhu, T., Wang, X., Kreps, J.A., and Kay, S.A. (2000). Orchestrated transcription of key pathways in Arabidopsis by the circadian clock. Science 290, 2110-2113.

10. Schaffer, R., Landgraf, J., Accerbi, M., Simon, V., Larson, M., and Wisman, E. (2001). Microarray analysis of diurnal and circadian-regulated genes in Arabidopsis. Plant Cell 13, 113-123.

11. Michael, T.P., and McClung, C.R. (2003). Enhancer trapping reveals widespread circadian clock transcriptional control in Arabidopsis. Plant Physiol 132, 629-639.

12. Alabadi, D., Oyama, T., Yanovsky, M.J., Harmon, F.G., Mas, P., and Kay, S.A. (2001). Reciprocal regulation between TOC1 and LHY/CCA1 within the Arabidopsis circadian clock. Science 293, 880-883.

13. Green, R.M., and Tobin, E.M. (1999). Loss of the circadian clock-associated protein 1 in Arabidopsis results in altered clock-regulated gene expression. Proc Natl Acad Sci U S A 96, 4176-4179.

14. Alabadi, D., Yanovsky, M.J., Mas, P., Harmer, S.L., and Kay, S.A. (2002). Critical role for CCA1 and LHY in maintaining circadian rhythmicity in Arabidopsis. Curr Biol 12, 757-761.

15. Mizoguchi, T., Wheatley, K., Hanzawa, Y., Wright, L., Mizoguchi, M., Song, H.R., Carre, I.A., and Coupland, G. (2002). LHY and CCA1 are partially redundant genes required to maintain circadian rhythms in Arabidopsis. Dev Cell 2, 629-641.

16. Locke, J.C., Millar, A.J., and Turner, M.S. (2005). Modelling genetic networks with noisy and varied experimental data: the circadian clock in Arabidopsis thaliana. J Theor Biol 234, 383-393.

17. Somers, D.E., Webb, A.A., Pearson, M., and Kay, S.A. (1998). The short-period mutant, toc1-1, alters circadian clock regulation of multiple outputs throughout development in Arabidopsis thaliana. Development 125, 485-494.

18. Matsushika, A., Makino, S., Kojima, M., and Mizuno, T. (2000). Circadian waves of expression of the APRR1/TOC1 family of pseudo-response regulators in Arabidopsis thaliana: insight into the plant circadian clock. Plant Cell Physiol 41, 1002-1012.

19. Hazen, S.P., Schultz, T.F., Pruneda-Paz, J.L., Borevitz, J.O., Ecker, J.R., and Kay, S.A. (2005). LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms. Proc Natl Acad Sci U S A 102, 10387-10392.

20. Schaffer, R., Ramsay, N., Samach, A., Corden, S., Putterill, J., Carre, I.A., and Coupland, G. (1998). The late elongated hypocotyl mutation of Arabidopsis disrupts circadian rhythms and the photoperiodic control of flowering. Cell 93, 1219-1229.

21. Doyle, M.R., Davis, S.J., Bastow, R.M., McWatters, H.G., Kozma-Bognar, L., Nagy, F., Millar, A.J., and Amasino, R.M. (2002). The ELF4 gene controls circadian rhythms and flowering time in Arabidopsis thaliana. Nature 419, 74-77.

22. Kikis, E.A., Khanna, R., and Quail, P.H. (2005). ELF4 is a phytochrome-regulated component of a negative-feedback loop involving the central oscillator components CCA1 and LHY. Plant J 44, 300-313.

23. Mas, P., Kim, W.Y., Somers, D.E., and Kay, S.A. (2003). Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana. Nature 426, 567-570.

24. Kiba, T., Henriques, R., Sakakibara, H., and Chua, N.H. (2007). Targeted Degradation of PSEUDO-RESPONSE REGULATOR5 by an SCFZTL Complex Regulates Clock Function and Photomorphogenesis in Arabidopsis thaliana. Plant Cell 19, 2516-2530.

25. Ito, S., Nakamichi, N., Kiba, T., Yamashino, T., and Mizuno, T. (2007). Rhythmic and Light-Inducible Appearance of Clock-Associated Pseudo-Response Regulator Protein PRR9 Through Programmed Degradation in the Dark in Arabidopsis thaliana. Plant Cell Physiol., pcm122.

26. Schultz, T.F., Kiyosue, T., Yanovsky, M., Wada, M., and Kay, S.A. (2001). A role for LKP2 in the circadian clock of Arabidopsis. Plant Cell 13, 2659-2670.

27. Nelson, D.C., Lasswell, J., Rogg, L.E., Cohen, M.A., and Bartel, B. (2000). FKF1, a clock-controlled gene that regulates the transition to flowering in Arabidopsis. Cell 101, 331-340.

28. Imaizumi, T., Schultz, T.F., Harmon, F.G., Ho, L.A., and Kay, S.A. (2005). FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis. Science 309, 293-297.

29. Imaizumi, T., Tran, H.G., Swartz, T.E., Briggs, W.R., and Kay, S.A. (2003). FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis. Nature 426, 302-306.

30. Sawa, M., Nusinow, D.A., Kay, S.A., and Imaizumi, T. (2007). FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis. Science 318, 261-265.

31. Kim, W.Y., Fujiwara, S., Suh, S.S., Kim, J., Kim, Y., Han, L.Q., David, K., Putterill, J., Nam, H.G., and Somers, D.E. (2007). ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light. Nature 449, 356.

32. Mizuno, T. (2004). Plant response regulators implicated in signal transduction and circadian rhythm. Curr Opin Plant Biol 7, 499-505.

33. Mizuno, T. (2005). Two-component phosphorelay signal transduction systems in plants: from hormone responses to circadian rhythms. Biosci Biotechnol Biochem 69, 2263-2276.

34. Turner, A., Beales, J., Faure, S., Dunford, R.P., and Laurie, D.A. (2005). The pseudo-response regulator Ppd-H1 provides adaptation to photoperiod in barley. Science 310, 1031-1034.

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