Fong:Research

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The Fong Lab is interested in bridging the gap between fundamental understanding of biological systems and the novel applications of this knowledge for society's benefit.

Major areas of interest are:

Systems biology

Systems biology has returned systems-level perspectives to biology. This approach is based on the fundamental understanding that biological systems are complex and highly interconnected. Thus, studying single biological components in isolation is not sufficient to fully describe the functionality of the integrated system.

In practice, this discipline has been associated with high-throughput analytical tools that allow simultaneous analysis of all biological components. One of the great challenges in this area is interpretation and integration of these data.

Evolutionary biology

Using microorganisms with fast growth rates allows biological adaptation to be investigated experimentally. Experiments of this nature allow us to study fundamental aspects of biology such as how pathogens become resistant to antibiotics and the relationship between genotype and phenotype.

This far in this area our lab has studied:

1. Computational methods for predicting growth behaviors of evolved E. coli
2. Reproducibility and adaptability of E. coli evolution
3. Molecular changes occurring during evolution using mRNA transcriptional profiling and metabolic flux analysis

Metabolic engineering

Metabolic engineering intends to intellegently alter the functionality of an organism for a desired purpose, often the production of a chemical of interest. Within a systems perspective, this is accomplished by analyzing how single modifications have effects on an entire biological system.

Progress in this area includes:

1. Computational modeling and prediction of strain designs for chemical production.
2. Construction and evolution of 3 strains of E. coli for production of lactic acid.
3. Characterization of production strains using mRNA transcriptional profiling.

Publications

coming soon...