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{{Frankel}}
{{Frankel}}
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== Welcome to the Frankel Group ==


Biological interfaces possess intriguing properties related to their function, an understanding of which can lead to treatments of disease, development of sophisticated medical implants and construction of bio/machine devices. Our particular expertise is in both investigating the fundamental science of these interfaces as well as trying to exploit them to build devices.
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'''Specifically we are looking at the following systems:''' <br> [[Image:CyberplasmVehicle-for_website.jpg|thumb|400px|right|'''Cyberplasm - A part biological / part machine swimming robot''']]
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== '''Welcome by P.I. Daniel Frankel''' ==
We are interested in the reductionist approach to biology which considers complex biological systems as machines allowing us to apply the laws of physics and rules of engineering to understand such systems. In particular we are working on building bio/machine hybrids bringing biological sensitivity and control to robotic devices. We are also interested in constructing artificial viruses for drug delivery (without the nasty infectious bits!!) and understanding/exploiting the ultimate bio/machine interface, the cell membrane. <br>


▪. '''The Cell Membrane''' - ''how do signals, biochemical and physical in origin, transmit through the cell membrane in order to control the cells machinery. Our ultimate goal in this area is to develop a new model of cell membrane structure and function.'' <br>
▪. '''Engineering Cells to Communicate with Electronics''' - '' Most attempts to interface living tissue with electronics involves finding novel approaches to building microelectronic probes. Our approach is to rebuild the biological systems so they can fit the electronics. This involves genetic engineering of cellular systems to enable them to produce a machine readable signal upon specified stimulation'' <br>
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<br>
▪. '''The Cell/Machine Interface'''- ''In this collaborative international project we are building a swimming biohybrid robot and in the process developing methods for encouraging cells to talk to electronics''  <br>
▪. '''Building Artificial Viruses'''- ''The virus particles infection strategy is ingenious. We would like to replicate this in synthetic particles for the delivery of drugs to targeted cells''  <br>
<br>
<br>
▪. '''Interfaces Involved in Disease''' - ''Cancer cell adhesion to the tumour surface results in tumour growth. We would like to be able to understand and manipulate such surfaces to prevent tumor growth and treat the disease.'' <br>
[[Image:GIF-VIRUS-INFECTION NEW.gif|350px]]
▪. ''' Building an Artificial Cell''' - ''A bottom up approach to assembling an artificial cell.'' <br>
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▪. '''Self Assembly of Small Biomolecules''' - ''Here we are trying to exploit self assembly in order to create nanoscale structures with potential technological applications'' <br>
▪. '''Cyberplasm''' - ''Building a swimmming bio hybrid microrobot'' <br>
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▪. ''' Building Model Cell Membranesl''' - ''The cell membrane is the ultimate signal transduction interface where external signals are passed through to genetic control in the innards of the cell. We are building model membranes out of biological components in order to better understand the structure/function relationship of the cell membrane.'' <br>
<br>
<br>
▪. '''Surfaces and Their Role in the Origin of Life on Earth''' <br>


We work at the interface between chemistry, biology and physics and employ both experimental and theoretical approaches. If you are interested in studying challenging systems involving complexity and are not afraid of inter-disciplinary work please don’t hesitate to contact me.
We work at the interface between chemistry, biology and physics and employ both experimental and theoretical approaches. If you are interested in studying challenging systems involving complexity and are not afraid of inter-disciplinary work please don’t hesitate to contact me.
Dr. Daniel Frankel : d.j.frankel@newcastle.ac.uk
Dr. Daniel Frankel : d.j.frankel@newcastle.ac.uk
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=='''LATEST NEWS''' !!==
Welcome to the lab to new PhD student Hani Sallam. He received his Meng in Chemical Engineering from Newcastle and will be working on a project to interface
living tissue with robots<br>
PhD opportunities<br>
<br>
1) Interfacing biological tissue with machines<br>
2) Mimicking the cell membrane to interface biological systems with electronics<br>
3) Building a living exoskeleton<br>
<br>
HIV paper makes front cover of Soft Matter:
[[Image:SoftCover.jpg|200px]]
Biorobot paper accepted!!
4 new papers in print related to protein unfolding
Welcome to the Lab to new PhD student Ana from Ecuador.
Cyberplasm receives media attention, here is the original press release [http://www.epsrc.ac.uk/newsevents/news/2012/Pages/livingmicrorobot.aspx living microrobot]
Congratulations to Orr Yarkoni for passing his PhD viva for a thesis entitled "Engineering an inducible NO pathway to facilitate cell-electronics communication"
Congratulations to Darman Nordin for passing his PhD viva for a thesis entitled "Interaction of the extracellular matrix protein fibronectin with model cell membranes"
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Latest revision as of 11:39, 17 September 2013

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Home=Frankel Members=#,Principal Investigator=Frankel:Lab_Members, PhD students=Frankel:Lab_Members, Alumni=Frankel:Lab_Members Contact=Frankel:Contact Collaborators=Frankel:Collaborators Publications=Frankel:Publications Lab=Frankel:Research Research=#,Force Spectroscopy=Frankel:Force Spectroscopy,HIV/Virus=Frankel:HIV/Virus,ECM Proteins=Frankel:ECM Proteins,Cyberplasm=Frankel:Cyberplasm,Cancer=Frankel:Cancer


Welcome by P.I. Daniel Frankel

We are interested in the reductionist approach to biology which considers complex biological systems as machines allowing us to apply the laws of physics and rules of engineering to understand such systems. In particular we are working on building bio/machine hybrids bringing biological sensitivity and control to robotic devices. We are also interested in constructing artificial viruses for drug delivery (without the nasty infectious bits!!) and understanding/exploiting the ultimate bio/machine interface, the cell membrane.

▪. Engineering Cells to Communicate with Electronics - Most attempts to interface living tissue with electronics involves finding novel approaches to building microelectronic probes. Our approach is to rebuild the biological systems so they can fit the electronics. This involves genetic engineering of cellular systems to enable them to produce a machine readable signal upon specified stimulation

▪. Building Artificial Viruses- The virus particles infection strategy is ingenious. We would like to replicate this in synthetic particles for the delivery of drugs to targeted cells

▪. Building an Artificial Cell - A bottom up approach to assembling an artificial cell.

▪. Cyberplasm - Building a swimmming bio hybrid microrobot

▪. Building Model Cell Membranesl - The cell membrane is the ultimate signal transduction interface where external signals are passed through to genetic control in the innards of the cell. We are building model membranes out of biological components in order to better understand the structure/function relationship of the cell membrane.

We work at the interface between chemistry, biology and physics and employ both experimental and theoretical approaches. If you are interested in studying challenging systems involving complexity and are not afraid of inter-disciplinary work please don’t hesitate to contact me. Dr. Daniel Frankel : d.j.frankel@newcastle.ac.uk

LATEST NEWS !!

Welcome to the lab to new PhD student Hani Sallam. He received his Meng in Chemical Engineering from Newcastle and will be working on a project to interface living tissue with robots

PhD opportunities

1) Interfacing biological tissue with machines
2) Mimicking the cell membrane to interface biological systems with electronics
3) Building a living exoskeleton

HIV paper makes front cover of Soft Matter:

Biorobot paper accepted!!

4 new papers in print related to protein unfolding

Welcome to the Lab to new PhD student Ana from Ecuador.

Cyberplasm receives media attention, here is the original press release living microrobot

Congratulations to Orr Yarkoni for passing his PhD viva for a thesis entitled "Engineering an inducible NO pathway to facilitate cell-electronics communication"

Congratulations to Darman Nordin for passing his PhD viva for a thesis entitled "Interaction of the extracellular matrix protein fibronectin with model cell membranes"

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