Frankel:ECM Proteins

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'''<font color=#045FB4 font size=3> Self assembly and pore formation of HIV gp160 revealed at molecular resolution
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'''<font color=#000000 font size=3> One of the major components of the extracellular matrix (ECM) is fibronectin, this dimeric glycoprotein is involved in numerous cell processes and has important functions in vertebrate development. 
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Self assembly of HIV gp160 reconstituted into DOPC bilayer and adsorbed onto mica.
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Fibronectin in the extracellular matrix interacts with the transmembrane integrins in a highly specific manner. The ECM ligand protein contains a tripeptide recognition site, Arg-Gly-Asp (RGD), responsible for the affinity of the cell surface receptors with its ligand. </font>'''
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gp160 forming pore like structures. </font>'''
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Revision as of 20:25, 8 November 2012

Danbanner-bio-machines.jpg


ECM Proteins









One of the major components of the extracellular matrix (ECM) is fibronectin, this dimeric glycoprotein is involved in numerous cell processes and has important functions in vertebrate development.

Fibronectin in the extracellular matrix interacts with the transmembrane integrins in a highly specific manner. The ECM ligand protein contains a tripeptide recognition site, Arg-Gly-Asp (RGD), responsible for the affinity of the cell surface receptors with its ligand.