Frankel:Force Spectroscopy

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'''<font align="center" font color=#ffffff font size=8>______ </font>''''''<font align="center" font color=#000000 font size=8>Force Spectroscopy</font>'''
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{| cellspacing="3px"
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|  align="center" width=400px style="border: 2px solid #000033; background-color:#FFFFFF; padding:1em;" class="plainlinks" valign="top"|
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'''<font color=#000000 font size=3>Picking up and unfolding a single protein</font>'''
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[[Image:Spectroscopy_complete.jpg|350px]]
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</div>
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| align="center" rowspan="2" width=21px style="border: 2px solid #000033; background-color:#ffffff; padding:1em;" valign="top"|
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'''<font color=#FFFFFF font size=3>Assembly</font>'''
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'''<font color=#000000 font size=3>Nano-mechanics of HIV GP160</font>'''
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[[Image:GP160mica.png|300px]]
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[[Image:GP_160.png|300px]]
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'''<font color=#FFFFFF font size=6>GP160mica</font>'''
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[[Image:Stlow.png|330px]]
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[[Image:Hislow.png|330px]]
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----
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'''<font color=#000000 font size=3 font align="justify">
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Typical sawtooth unfolding pattern of a single molecule of the HIV virion protein GP160. Unfolding forces can be extracted from the sawtooth pattern by applying the worm like chain model.</font>'''
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{|width="*"
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{| style="width: 728px;  text-align:center;font-size:12px;font-variant: small-caps;width: 18px; " align="justify"
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|----
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| align="center" width=21px style="border: 2px solid #000000; background-color:#FFFFFF; padding:1em;" valign="top"|
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'''<font color=#000000 font size=3> Unfolding the ECM protein fibronectin </font>'''
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[[Image:FNsawt.png|300px]]
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[[Image:HisFN.png|300px]]
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----
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'''<font align="justify" font size=3>  
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Sawtooth pattern on the retraction force curve indicating the unfolding of fibronectin. The average rupture force distribution of the protein on mica surface  was 85.1 ± 2.7 pN.

Current revision

Danbanner-bio-machines.jpg



'______ 'Force Spectroscopy


Assembly

Nano-mechanics of HIV GP160



GP160mica



Typical sawtooth unfolding pattern of a single molecule of the HIV virion protein GP160. Unfolding forces can be extracted from the sawtooth pattern by applying the worm like chain model.





Unfolding the ECM protein fibronectin



Sawtooth pattern on the retraction force curve indicating the unfolding of fibronectin. The average rupture force distribution of the protein on mica surface was 85.1 ± 2.7 pN.

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