Freimoser

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<h2><b>Florian M. Freimoser, PhD</b></h2>
<h2><b>Florian M. Freimoser, PhD</b></h2>
<h3>Institute of Plant Sciences</h3>
<h3>Institute of Plant Sciences</h3>
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Tel: +41 +44 632 38 44<br>
Tel: +41 +44 632 38 44<br>
Fax: +41 +44 632 10 44<br>
Fax: +41 +44 632 10 44<br>
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Please also visit our [http://www.polyphosphate.ethz.ch/ other web site!]
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<h3>The molecule we study is so plain<br>
<h3>The molecule we study is so plain<br>
the inorganic polyphosphate chain</h3>
the inorganic polyphosphate chain</h3>
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The focus of the research in
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Our group studies a simple
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our group is a simple
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molecule: <strong>inorganic
molecule: <strong>inorganic
polyphosphate (poly P)</strong>.<br>
polyphosphate (poly P)</strong>.<br>
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phosphate residues
phosphate residues
(from three to more than a thousand) that are
(from three to more than a thousand) that are
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linked by energy-rich phosphoanhydride bonds. It has been detected
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linked by energy-rich phosphoanhydride bonds. It occurs ubiquitously in all living cells and regulates many molecular and biological processes. Nevertheless, poly P is scarcely studied and little is known about poly P metabolism and its exact molecular functions; especially in eukaryotes. In our group we have developed methods to quantify poly P, to stain and localize poly P and to screen for poly P binding proteins. We are using these tools to investigate poly P metabolism and functions in fungi, plants and algae. However, at the moment our main efforts are devoted to the study of poly P metabolism in the yeast ''Saccharomyces cerevisiae'' and of poly P in fungal cell walls.
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in all organisms and living cells and was found in many organelles.
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In eukaryotes, poly P is particularly
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prominent in fungi, algae and trypanosomatids.
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Poly P serves as a phosphate and energy store and regulates
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enzymes, chromatin condensation
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and translation. Poly P is also involved in bacterial pathogenicity,
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survival during stationary phase in
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bacteria and yeast, or the adaptation to alkaline and osmotic stress.
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In the slime mold <i>Dictyostelium discoideum</i>, poly P regulates
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development and predation behaviour, and in humans blood coagulation is
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accelerated and fibrinolysis is delayed by poly P.
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In our group we study poly P metabolism and functions in eukaryotes and
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we work mostly with yeast, filamentous fungi and algae.
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__NOTOC__
__NOTOC__

Current revision


Florian M. Freimoser, PhD

Institute of Plant Sciences

Biochemistry and Physiology of Plants ETH Zurich, LFW D46.1
Universitätsstr. 2
CH-8092 Zurich
Switzerland
Tel: +41 +44 632 38 44
Fax: +41 +44 632 10 44

Please also visit our other web site!

The molecule we study is so plain
the inorganic polyphosphate chain

Our group studies a simple molecule: inorganic polyphosphate (poly P).
Poly P is a linear polymer that consists of a variable number of phosphate residues (from three to more than a thousand) that are linked by energy-rich phosphoanhydride bonds. It occurs ubiquitously in all living cells and regulates many molecular and biological processes. Nevertheless, poly P is scarcely studied and little is known about poly P metabolism and its exact molecular functions; especially in eukaryotes. In our group we have developed methods to quantify poly P, to stain and localize poly P and to screen for poly P binding proteins. We are using these tools to investigate poly P metabolism and functions in fungi, plants and algae. However, at the moment our main efforts are devoted to the study of poly P metabolism in the yeast Saccharomyces cerevisiae and of poly P in fungal cell walls.


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