Freimoser

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<h2><b>Florian M. Freimoser, PhD</b></h2>
<h2><b>Florian M. Freimoser, PhD</b></h2>
<h3>Institute of Plant Sciences</h3>
<h3>Institute of Plant Sciences</h3>
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Tel: +41 +44 632 38 44<br>
Tel: +41 +44 632 38 44<br>
Fax: +41 +44 632 10 44<br>
Fax: +41 +44 632 10 44<br>
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Please also visit our [http://www.polyphosphate.ethz.ch/ other web site!]
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<h3>The molecule we study is so plain<br>
<h3>The molecule we study is so plain<br>
the inorganic polyphosphate chain</h3>
the inorganic polyphosphate chain</h3>
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The focus of the research in
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Our group studies a simple
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our group is a simple
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molecule: <strong>inorganic
molecule: <strong>inorganic
polyphosphate (poly P)</strong>.<br>
polyphosphate (poly P)</strong>.<br>
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phosphate residues
phosphate residues
(from three to more than a thousand) that are
(from three to more than a thousand) that are
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linked by energy-rich phosphoanhydride bonds. It has been detected
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linked by energy-rich phosphoanhydride bonds. It occurs ubiquitously in all living cells and regulates many molecular and biological processes. Nevertheless, poly P is scarcely studied and little is known about poly P metabolism and its exact molecular functions; especially in eukaryotes. In our group we have developed methods to quantify poly P, to stain and localize poly P and to screen for poly P binding proteins. We are using these tools to investigate poly P metabolism and functions in fungi, plants and algae. However, at the moment our main efforts are devoted to the study of poly P metabolism in the yeast ''Saccharomyces cerevisiae'' and of poly P in fungal cell walls.
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in all organisms and living cells and was found in many organelles.
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In eukaryotes, poly P is particularly
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prominent in fungi, algae and trypanosomatids.
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Poly P serves as a phosphate and energy store and regulates
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enzymes, chromatin condensation
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and translation. Poly P is also involved in bacterial pathogenicity,
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survival during stationary phase in
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bacteria and yeast, or the adaptation to alkaline and osmotic stress.
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In the slime mold <i>Dictyostelium discoideum</i>, poly P regulates
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development and predation behaviour, and in humans blood coagulation is
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accelerated and fibrinolysis is delayed by poly P.
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In our group we study poly P metabolism and functions in eukaryotes and
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we work mostly with yeast, filamentous fungi and algae.
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Current revision

Florian's Lab    People     Research     Publications     Protocols     Recipes     Links     Contact     Group info    


Florian M. Freimoser, PhD

Institute of Plant Sciences

Biochemistry and Physiology of Plants ETH Zurich, LFW D46.1
Universitätsstr. 2
CH-8092 Zurich
Switzerland
Tel: +41 +44 632 38 44
Fax: +41 +44 632 10 44

Please also visit our other web site!

The molecule we study is so plain
the inorganic polyphosphate chain

Our group studies a simple molecule: inorganic polyphosphate (poly P).
Poly P is a linear polymer that consists of a variable number of phosphate residues (from three to more than a thousand) that are linked by energy-rich phosphoanhydride bonds. It occurs ubiquitously in all living cells and regulates many molecular and biological processes. Nevertheless, poly P is scarcely studied and little is known about poly P metabolism and its exact molecular functions; especially in eukaryotes. In our group we have developed methods to quantify poly P, to stain and localize poly P and to screen for poly P binding proteins. We are using these tools to investigate poly P metabolism and functions in fungi, plants and algae. However, at the moment our main efforts are devoted to the study of poly P metabolism in the yeast Saccharomyces cerevisiae and of poly P in fungal cell walls.


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