Freimoser

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<h3>[[Freimoser:Group|Group]]</h3>
 
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*[[User:mstadler|Martha Stadler]]<BR>
 
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* [[User:Huerlimann|Hans Caspar Hürlimann]]<BR>
 
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* [[User:werner|Thomas Werner]]<BR>
 
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* [[User:freimoser|Florian Freimoser]]<BR>
 
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<h3>[[Freimoser:Research|Research]]</h3>
 
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*Projects
 
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*Poly P
 
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<h3>[[Freimoser:Publications|Publications]]</h3>
 
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<h3>[[Freimoser:Protocols|Protocols]]</h3>
 
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* [[Freimoser:Protocols:Yeast|Yeast]]
 
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*Poly P
 
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*DNA
 
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*Protein
 
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<h3>[[Freimoser:Recipes|Recipes]]</h3>
 
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*Yeast media
 
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*Other media
 
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*Buffers (DNA)
 
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*Buffers (Proteins)
 
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<h3>[[Freimoser:Contact|Contact]]</h3>
 
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ETH Zurich<BR>
 
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Institute of Plant Sciences<BR>
 
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Universitätsstr. 2<BR>
 
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8092 Zürich<BR>
 
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Switzerland<BR>
 
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Revision as of 16:08, 6 October 2006

The molecule we study is so plain
the inorganic polyphosphate chain

The focus of the research in our group is a simple molecule: inorganic polyphosphate (poly P).
Poly P is a linear polymer that consists of a variable number of phosphate residues (from three to more than a thousand) that are linked by energy-rich phosphoanhydride bonds. It has been detected in all organisms and living cells and was found in many organelles. In eukaryotes, poly P is particularly prominent in fungi, algae and trypanosomatids. Poly P serves as a phosphate and energy store and regulates enzymes, chromatin condensation and translation. Poly P is also involved in bacterial pathogenicity, survival during stationary phase in bacteria and yeast, or the adaptation to alkaline and osmotic stress. In the slime mold Dictyostelium discoideum, poly P regulates development and predation behaviour, and in humans blood coagulation is accelerated and fibrinolysis is delayed by poly P. In our group we study poly P metabolism and functions in eukaryotes and we work mostly with yeast, filamentous fungi and algae.

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