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Revision as of 21:19, 24 February 2009
Our research program combines mouse genetics, cell biological and biochemical approaches to investigate the interplay between signal transduction pathways and the actin cytoskeleton, and to deduce the functional importance of these regulatory systems in organismal development and disease etiology. One focus of the lab involves the study of cell motility and the control of cellular protrusions. A related second focus involves studying migration of neurons and their growth cones, actin-rich structures that guide developing axons and dendrites to their targets. We utilize fluorescence and time-lapse video microscopy of living cells and high-resolution electron microscopy to analyze and quantify these processes. |