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==Contact Info==
==Contact Info==
[[Image:OWWEmblem.png|thumb|right|L. Richard-Parpaillon (an artistic interpretation)]]
[[Image:GIET_R.jpg|thumb|left]]


*Régis GIET
*Régis GIET
*UMR6061-CNRS. Institut de Génétique et Développement de Rennes.
*UMR6290-CNRS. Institut de Génétique et Développement de Rennes.
*Faculté de Médecine
*Faculté de Médecine
*2 avenue du Professeur Léon Bernard
*2 avenue du Professeur Léon Bernard
Line 12: Line 13:
*email : regis.giet@univ-rennes1.fr
*email : regis.giet@univ-rennes1.fr


==Education==
<br>
PhD of Biology, University of Rennes 1, "Study of te function and regulation of the Aurora A protein kinase"  
<br>
 
<br>
==Professional experiments==
<br>
==Biography==
* Since 2010 : Group leader "Cytoskeleton and Cell Proliferation"
* 2008 : CNRS Bronze medal [http://www.cnrs.fr/fr/recherche/prix/docs/bronze2008/GietR.pdf]
* Since 2002 : CNRS researcher (Group leader) at the UMR-6061-CNRS, Institut de Génétique et Développement de Rennes
* Since 2002 : CNRS researcher (Group leader) at the UMR-6061-CNRS, Institut de Génétique et Développement de Rennes
* 2000-2002  : Research associate at the University of Cambridge(UK). Department of Genetic, Regulation of Mitosis and Meiosis Group (Head : Pr.David Glover)
* 2000-2002  : Research associate at the University of Cambridge(UK). Department of Genetic, Regulation of Mitosis and Meiosis Group (Head : Pr.David Glover)
* 1999 : PhD of Biology, University of Rennes 1, "Study of te function and regulation of the Aurora A protein kinase"


==Publications==
==Publications==
*Ensconsin/Map7 promotes microtubule growth and centrosome separation in Drosophila neural stem cells.
:Gallaud E, Caous R, Pascal A, Bazile F, Gagné JP, Huet S, Poirier GG, Chrétien D, Richard-Parpaillon L, '''Giet R'''.
:J Cell Biol. 2014 Mar 31;204(7)[http://jcb.rupress.org/content/204/7/1111.long]
*CDK11p58 kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis.
:Rakkaa T, Escudé C, '''Giet R''', Magnaghi-Jaulin L, Jaulin C.
:Chromosome Res. 2014 Jan 17.
*MNK1 kinase activity is required for abscission.
:Rannou Y, Salaun P, Benaud C, Khan J, Dutertre S, '''Giet R''', Prigent C.
:J Cell Sci. 2012 Jun 15;125(Pt 12):2844-52.


*CDK11 is required for centriole duplication and Plk4  targeting to the mitotic centrosome. PLoS ONE, 6 (1).
*CDK11 is required for centriole duplication and Plk4  targeting to the mitotic centrosome. PLoS ONE, 6 (1).
:Franck, N., Montembault, E., Romé, P.,  Pascal, A., Cremet, J. Y. and Giet, R. (2011).  
:Franck, N., Montembault, E., Romé, P.,  Pascal, A., Cremet, J. Y. and '''Giet, R'''. (2011).  


*Aurora A participates to dynactin phoshorylation and function during mitosis. Journal of Cell Biology , 2010, 189(4):651-9.
*Aurora A participates to dynactin phoshorylation and function during mitosis. Journal of Cell Biology , 2010, 189(4):651-9.
:Romé, P., Montembault, E., Franck, N., Pascal, A., Glover, D. M., and Giet, R. (2010).  
:Romé, P., Montembault, E., Franck, N., Pascal, A., Glover, D. M., and '''Giet, R'''. (2010).  


*Centrosome, microtubule and cancer. Medecine  Sciences. (2010), 26(4):377-383.
*Centrosome, microtubule and cancer. Medecine  Sciences. (2010), 26(4):377-383.
:Romé, P., Prigent., and Giet, R.  
:Romé, P., Prigent., and '''Giet, R'''.  


*Human Prp4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural Molecular Biology (2010), 17(2):216-221.
*Human Prp4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural Molecular Biology (2010), 17(2):216-221.
:Marc Schneider, He-Hsuan Hsiao, Cindy L. Will, Régis Giet, Henning Urlaub & Reinhard Lührmann.
:Marc Schneider, He-Hsuan Hsiao, Cindy L. Will, '''Régis Giet''', Henning Urlaub & Reinhard Lührmann.


*PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1 and MAD2 localisation to the kinetochores.
 Journal of Cell Biology (2007), 179(4):601-609.
*PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1 and MAD2 localisation to the kinetochores.
 Journal of Cell Biology (2007), 179(4):601-609.
:Montembault, E., Dutertre, S.,  Prigent. C, and Giet, R.  
:Montembault, E., Dutertre, S.,  Prigent. C, and '''Giet, R'''.  


*Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells.
Journal of Cell Science 2006, 119(21):4431-4441.
*Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells.
Journal of Cell Science 2006, 119(21):4431-4441.
:Delcros, J., G, Prigent, C. and Giet, R.  
:Delcros, J., G, Prigent, C. and '''Giet, R'''.  


*CDK11p58 is required for spindle morphogenesis and centrosome maturation.  EMBO report.(2006) 7(4):418-424
*CDK11p58 is required for spindle morphogenesis and centrosome maturation.  EMBO report.(2006) 7(4):418-424
:Petretti, C., Savoian, M., Glover, D., M., Prigent, C. and Giet, R.
:Petretti, C., Savoian, M., Glover, D., M., Prigent, C. and '''Giet, R'''.


*Aurora kinases, aneuploidy and cancer, a coincidence or a real link?. Trends in Cell Biology, 2005, 15(5):241-250
*Aurora kinases, aneuploidy and cancer, a coincidence or a real link?. Trends in Cell Biology, 2005, 15(5):241-250
:Giet R, Petretti C, Prigent C.
:'''Giet R''', Petretti C, Prigent C.


*Drosophila Nek2 protein kinase is require to regulate centrosome and cytokinesis. Experimental Cell Research (2005), 303(1):1-13.  
*Drosophila Nek2 protein kinase is require to regulate centrosome and cytokinesis. Experimental Cell Research (2005), 303(1):1-13.  
:Prigent, C., Glover, DM. And Giet, R. (2005).  
:Prigent, C., Glover, DM. And '''Giet, R'''. (2005).  


*Genome wide survey of protein kinases required for cell cycle progression. Nature, 2004, 432(7020):980-987.
*Genome wide survey of protein kinases required for cell cycle progression. Nature, 2004, 432(7020):980-987.
:Bettencourt-Dias M, Giet R, Sinka R, Mazumdar A, Lock WG,Balloux F, Zafiropoulos PJ, Yamaguchi S, Winter S, Carthew RW, Cooper M, Jones D, Frenz LM, Glover DM.  
:Bettencourt-Dias M, '''Giet R''', Sinka R, Mazumdar A, Lock WG,Balloux F, Zafiropoulos PJ, Yamaguchi S, Winter S, Carthew RW, Cooper M, Jones D, Frenz LM, Glover DM.  


*The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itselfundergoes cyclical degradation. Current Biology, 2004, 14(19):1723-1733.
*The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itselfundergoes cyclical degradation. Current Biology, 2004, 14(19):1723-1733.
:Mathe E, Kraft C, Giet R, Deak P, Peters JM, Glover DM.
:Mathe E, Kraft C, '''Giet R''', Deak P, Peters JM, Glover DM.


*Aurora A and mitotic commitment. Cell.(2003) 114, 531-2.
*Aurora A and mitotic commitment. Cell.(2003) 114, 531-2.
:Prigent,C and Giet,R.  
:Prigent,C and '''Giet,R'''.  


*Control by centrosome of asymmetric repartition of cellular components. (2003). Medecine Science.19, 6-7.
*Control by centrosome of asymmetric repartition of cellular components. (2003). Medecine Science.19, 6-7.
:Giet, R and Prigent, C.  
:'''Giet, R''' and Prigent, C.  


*Aurora A, act 2, scene 2: not only at the centrosome. ELSO Gaz., 2002, (10) http://www.the-elso-gazette.org/magazines/issue10/mreviews/mreviews6.asp   
*Aurora A, act 2, scene 2: not only at the centrosome. ELSO Gaz., 2002, (10) http://www.the-elso-gazette.org/magazines/issue10/mreviews/mreviews6.asp   
:Giet, R.
:'''Giet, R'''.


*Drosophila auroraA kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. Journal of Cell Biology (2001).156. 437-451.
*Drosophila auroraA kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. Journal of Cell Biology (2001).156. 437-451.
:Giet, R., MacLean, D. Descamps, S., Lee,MJ., Raff, JW., Prigent, C., and Glover, DM.  
:'''Giet, R.''', MacLean, D. Descamps, S., Lee,MJ., Raff, JW., Prigent, C., and Glover, DM.  


*Identification of a functional destruction box in the Xenopus laevis aurora-A kinase pEg2. FEBS Letter (2001)508, 149-52.
*Identification of a functional destruction box in the Xenopus laevis aurora-A kinase pEg2. FEBS Letter (2001)508, 149-52.
:Arlot-Bonnemain Y, Klotzbucher, A.Giet, R.Uzbekov, R.Bihan, R.Prigent, C.  
:Arlot-Bonnemain Y, Klotzbucher, A.'''Giet, R'''.Uzbekov, R.Bihan, R.Prigent, C.  


*The non-catalytic domain of the Xenopus laevis auroraA kinase localises the protein to the centrosome. (2001). Journal of Cell Science.114, 2095-104.
*The non-catalytic domain of the Xenopus laevis auroraA kinase localises the protein to the centrosome. (2001). Journal of Cell Science.114, 2095-104.
:Giet, R and Prigent, C.  
:'''Giet, R''' and Prigent, C.  


*Drosophila Aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organise the central spindle during cytokinesis. Journal of Cell Biology (2001) 152, 669-81.
*Drosophila Aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organise the central spindle during cytokinesis. Journal of Cell Biology (2001) 152, 669-81.
:Giet, R. and Glover, D. M.G.  
:'''Giet, R.''' and Glover, D. M.G.  


*The Xenopus laevis centrosome aurora-related-kinase pEg2. Biology of the Cell (1999) 91, 461-70.
*The Xenopus laevis centrosome aurora-related-kinase pEg2. Biology of the Cell (1999) 91, 461-70.
:Giet R., Uzbekov, R., Kiriev, I.,  and Prigent, C. (1999)  
:'''Giet R.''', Uzbekov, R., Kiriev, I.,  and Prigent, C. (1999)  


*The Xenopus laevis Aurora/Ipl1p-related kinase pEg2 participates to the bipolar spindle stability. Experimental Cell Research (2000). 258, 145-51.
*The Xenopus laevis Aurora/Ipl1p-related kinase pEg2 participates to the bipolar spindle stability. Experimental Cell Research (2000). 258, 145-51.
:Giet, R. and Prigent, C.   
:'''Giet, R.''' and Prigent, C.   


*Aurora/Ipl1p-related kinases a new oncogenic family of serine threonine kinases. Journal of Cell Science (1999)112, 3591-601.
*Aurora/Ipl1p-related kinases a new oncogenic family of serine threonine kinases. Journal of Cell Science (1999)112, 3591-601.
:Giet, R. and Prigent, C.  
:'''Giet, R.''' and Prigent, C.  


*The Xenopus leavis protein kinase pEg2 interacts with and phosphorylates the Kinesin Like Protein XlEg5. Journal of Biological Chemistry (1998) 274, 15005-15013.
*The Xenopus leavis protein kinase pEg2 interacts with and phosphorylates the Kinesin Like Protein XlEg5. Journal of Biological Chemistry (1998) 274, 15005-15013.
:Giet, R., Uzbekov, R., Cubizolles, F., Le Guellec, K. and Prigent C.  
:'''Giet, R.''', Uzbekov, R., Cubizolles, F., Le Guellec, K. and Prigent C.  


*A method for in situ spindle binding assay. Experiemtal Cell Research (1998) 244, 470-473.
*A method for in situ spindle binding assay. Experiemtal Cell Research (1998) 244, 470-473.
:Giet, R. and Prigent, C.  
:'''Giet, R.''' and Prigent, C.  


*The Xenopus Protein Kinase pEg2 Associates with the Centrosome in a Cell Cycle-Dependent Manner, Binds to the Spindle Microtubules and is involved in Bipolar Mitotic Spindle Assembly. Journal of Cell Science (1998) 111, 557-572. Awarded best paper of the year.
*The Xenopus Protein Kinase pEg2 Associates with the Centrosome in a Cell Cycle-Dependent Manner, Binds to the Spindle Microtubules and is involved in Bipolar Mitotic Spindle Assembly. Journal of Cell Science (1998) 111, 557-572. Awarded best paper of the year.
:Roghi, C., Giet, R., Uzbekov, R., Morin, N., Chartrain, I., Le Guellec, R., Anne Couturier, A., Dorée, M., Philippe, M., and Prigent, C.
:Roghi, C., '''Giet, R.''', Uzbekov, R., Morin, N., Chartrain, I., Le Guellec, R., Anne Couturier, A., Dorée, M., Philippe, M., and Prigent, C.

Revision as of 05:54, 15 July 2014

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Contact Info

  • Régis GIET
  • UMR6290-CNRS. Institut de Génétique et Développement de Rennes.
  • Faculté de Médecine
  • 2 avenue du Professeur Léon Bernard
  • 35043 RENNES Cedex
  • phone : 33 (0)2.23.23.49.98
  • email : regis.giet@univ-rennes1.fr





Biography

  • Since 2010 : Group leader "Cytoskeleton and Cell Proliferation"
  • 2008 : CNRS Bronze medal [1]
  • Since 2002 : CNRS researcher (Group leader) at the UMR-6061-CNRS, Institut de Génétique et Développement de Rennes
  • 2000-2002  : Research associate at the University of Cambridge(UK). Department of Genetic, Regulation of Mitosis and Meiosis Group (Head : Pr.David Glover)
  • 1999 : PhD of Biology, University of Rennes 1, "Study of te function and regulation of the Aurora A protein kinase"

Publications

  • Ensconsin/Map7 promotes microtubule growth and centrosome separation in Drosophila neural stem cells.
Gallaud E, Caous R, Pascal A, Bazile F, Gagné JP, Huet S, Poirier GG, Chrétien D, Richard-Parpaillon L, Giet R.
J Cell Biol. 2014 Mar 31;204(7)[2]
  • CDK11p58 kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis.
Rakkaa T, Escudé C, Giet R, Magnaghi-Jaulin L, Jaulin C.
Chromosome Res. 2014 Jan 17.
  • MNK1 kinase activity is required for abscission.
Rannou Y, Salaun P, Benaud C, Khan J, Dutertre S, Giet R, Prigent C.
J Cell Sci. 2012 Jun 15;125(Pt 12):2844-52.
  • CDK11 is required for centriole duplication and Plk4 targeting to the mitotic centrosome. PLoS ONE, 6 (1).
Franck, N., Montembault, E., Romé, P., Pascal, A., Cremet, J. Y. and Giet, R. (2011).
  • Aurora A participates to dynactin phoshorylation and function during mitosis. Journal of Cell Biology , 2010, 189(4):651-9.
Romé, P., Montembault, E., Franck, N., Pascal, A., Glover, D. M., and Giet, R. (2010).
  • Centrosome, microtubule and cancer. Medecine Sciences. (2010), 26(4):377-383.
Romé, P., Prigent., and Giet, R.
  • Human Prp4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural Molecular Biology (2010), 17(2):216-221.
Marc Schneider, He-Hsuan Hsiao, Cindy L. Will, Régis Giet, Henning Urlaub & Reinhard Lührmann.
  • PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1 and MAD2 localisation to the kinetochores.
 Journal of Cell Biology (2007), 179(4):601-609.
Montembault, E., Dutertre, S., Prigent. C, and Giet, R.
  • Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells.
Journal of Cell Science 2006, 119(21):4431-4441.
Delcros, J., G, Prigent, C. and Giet, R.
  • CDK11p58 is required for spindle morphogenesis and centrosome maturation. EMBO report.(2006) 7(4):418-424
Petretti, C., Savoian, M., Glover, D., M., Prigent, C. and Giet, R.
  • Aurora kinases, aneuploidy and cancer, a coincidence or a real link?. Trends in Cell Biology, 2005, 15(5):241-250
Giet R, Petretti C, Prigent C.
  • Drosophila Nek2 protein kinase is require to regulate centrosome and cytokinesis. Experimental Cell Research (2005), 303(1):1-13.
Prigent, C., Glover, DM. And Giet, R. (2005).
  • Genome wide survey of protein kinases required for cell cycle progression. Nature, 2004, 432(7020):980-987.
Bettencourt-Dias M, Giet R, Sinka R, Mazumdar A, Lock WG,Balloux F, Zafiropoulos PJ, Yamaguchi S, Winter S, Carthew RW, Cooper M, Jones D, Frenz LM, Glover DM.
  • The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itselfundergoes cyclical degradation. Current Biology, 2004, 14(19):1723-1733.
Mathe E, Kraft C, Giet R, Deak P, Peters JM, Glover DM.
  • Aurora A and mitotic commitment. Cell.(2003) 114, 531-2.
Prigent,C and Giet,R.
  • Control by centrosome of asymmetric repartition of cellular components. (2003). Medecine Science.19, 6-7.
Giet, R and Prigent, C.
Giet, R.
  • Drosophila auroraA kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. Journal of Cell Biology (2001).156. 437-451.
Giet, R., MacLean, D. Descamps, S., Lee,MJ., Raff, JW., Prigent, C., and Glover, DM.
  • Identification of a functional destruction box in the Xenopus laevis aurora-A kinase pEg2. FEBS Letter (2001)508, 149-52.
Arlot-Bonnemain Y, Klotzbucher, A.Giet, R.Uzbekov, R.Bihan, R.Prigent, C.
  • The non-catalytic domain of the Xenopus laevis auroraA kinase localises the protein to the centrosome. (2001). Journal of Cell Science.114, 2095-104.
Giet, R and Prigent, C.
  • Drosophila Aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organise the central spindle during cytokinesis. Journal of Cell Biology (2001) 152, 669-81.
Giet, R. and Glover, D. M.G.
  • The Xenopus laevis centrosome aurora-related-kinase pEg2. Biology of the Cell (1999) 91, 461-70.
Giet R., Uzbekov, R., Kiriev, I., and Prigent, C. (1999)
  • The Xenopus laevis Aurora/Ipl1p-related kinase pEg2 participates to the bipolar spindle stability. Experimental Cell Research (2000). 258, 145-51.
Giet, R. and Prigent, C.
  • Aurora/Ipl1p-related kinases a new oncogenic family of serine threonine kinases. Journal of Cell Science (1999)112, 3591-601.
Giet, R. and Prigent, C.
  • The Xenopus leavis protein kinase pEg2 interacts with and phosphorylates the Kinesin Like Protein XlEg5. Journal of Biological Chemistry (1998) 274, 15005-15013.
Giet, R., Uzbekov, R., Cubizolles, F., Le Guellec, K. and Prigent C.
  • A method for in situ spindle binding assay. Experiemtal Cell Research (1998) 244, 470-473.
Giet, R. and Prigent, C.
  • The Xenopus Protein Kinase pEg2 Associates with the Centrosome in a Cell Cycle-Dependent Manner, Binds to the Spindle Microtubules and is involved in Bipolar Mitotic Spindle Assembly. Journal of Cell Science (1998) 111, 557-572. Awarded best paper of the year.
Roghi, C., Giet, R., Uzbekov, R., Morin, N., Chartrain, I., Le Guellec, R., Anne Couturier, A., Dorée, M., Philippe, M., and Prigent, C.
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