Guillaume Lesage: Difference between revisions

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Projects: Light-inducible gene regulation system / Engineering and pseudotyping of the Duck Hepatitis B Virus (DHBV)<br/>
Projects: Light-inducible gene regulation system / Engineering and pseudotyping of the Duck Hepatitis B Virus (DHBV)<br/>


*Oct 2003 - Jul 2004: [http://www.livercenter.nl/page.php?page=1922&menu=3&parent=1908 Seppen Lab], [http://www.livercenter.nl/ AMC Liver Center], University of Amsterdam, The Netherlands: ''"Lentiviral Gene Transfer of Chemically Inducible Hepatocyte Growth Factor Receptor and Liver Re-Targeting of Lentiviral Particles"'' / Supervisors: Dr. Jurgen Seppen, Prof. Ronald P.J. Oude-Elferink
*Oct 2003 - Jul 2004: [http://www.neb.com New England Biolabs, Inc.], Beverly, MA, USA
Supervisor: Dr. M.-Q. Xu
Project: Protein transduction assays on eukaryotic cells


*Jan - Sep 2003: [http://www.lrz-muenchen.de/~Biologische-Chemie/ Skerra Lab], [http://www.lrz-muenchen.de/~Biologische-Chemie/ Institute of Biological Chemistry], Technical University of Munich, Germany: ''"Production and characterization of the enzymatically active domain of the endolysine Ply500 isolated from Listeria monocytogenes-bacteriophage A 500"'' / Supervisors: Dr. Ingo P. Korndörfer, Prof. Arne Skerra
*Jan - Sep 2003: [http://www.neb.com New England Biolabs, Inc.], Beverly, MA, USA
Supervisor: Dr. M.-Q. Xu
Projects: Mutagenesis study of the Ssp DnaB mini-intein / Catalytic RNA in RNAi production


==Education==
==Education==

Revision as of 06:08, 15 October 2008

Contact Info

File:Guillaume Lesage.JPG
  • Guillaume Lesage
  • University of Zurich

     Institute of Molecular Biology / Hemmi Lab
     Winterthurerstrasse 190
     8057 Zurich
     Switzerland

Research interests

  • Virology
  • MicroRNAs

Current position

PhD Student in the Hemmi Lab, Institute of Molecular Biology, University of Zurich
Projects:

  • Engineering of Oncolytic CRAds for Melanoma Treatment
  • Study on Potential miRNAs Encoded by Human Adenoviruses

Founding member of the MicroRNA Network Zurich (MiNZ).

Previous labs

Previous labs

Supervisors: Dr. J. Stitz, Prof. M. Fussenegger
Projects: Light-inducible gene regulation system / Engineering and pseudotyping of the Duck Hepatitis B Virus (DHBV)

Supervisor: Dr. M.-Q. Xu Project: Protein transduction assays on eukaryotic cells

Supervisor: Dr. M.-Q. Xu Projects: Mutagenesis study of the Ssp DnaB mini-intein / Catalytic RNA in RNAi production

Education

  • Master Degree of Science in Biotechnology
  • Diplôme d’ingénieur en Biotechnologie
  • Diplôme d’Etude Approfondie (DEA) in Cellular and Molecular Biology

Ecole supérieure de Biotechnologie de Strasbourg (ESBS) (graduated September 2003 in Strasbourg, France)
Tri-lingual (French, English and German) Biotechnology Masters program emphasizing practical laboratory training

  • Diplôme d'études universitaires générales (DEUG) in Biology

Institut d'Ecologie Appliquée, Université catholique de l'Ouest (graduated August 2000 in Angers, France)

Publications

  1. Galgano A, Forrer M, Jaskiewicz L, Kanitz A, Zavolan M, and Gerber AP. Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system. PLoS One. 2008 Sep 8;3(9):e3164. DOI:10.1371/journal.pone.0003164 | PubMed ID:18776931 | HubMed [Paper3]
  2. Fluri DA, Kelm JM, Lesage G, Baba MD, and Fussenegger M. InXy and SeXy, compact heterologous reporter proteins for mammalian cells. Biotechnol Bioeng. 2007 Oct 15;98(3):655-67. DOI:10.1002/bit.21461 | PubMed ID:17461419 | HubMed [Paper2]
  3. Ding Y, Xu MQ, Ghosh I, Chen X, Ferrandon S, Lesage G, and Rao Z. Crystal structure of a mini-intein reveals a conserved catalytic module involved in side chain cyclization of asparagine during protein splicing. J Biol Chem. 2003 Oct 3;278(40):39133-42. DOI:10.1074/jbc.M306197200 | PubMed ID:12878593 | HubMed [Paper1]

All Medline abstracts: PubMed | HubMed

Useful links