Gunawan:Ang Kok Siong

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
(Research interests)
(Research interests)
Line 25: Line 25:
-
[b] Paremeter Estimation of Oscillatory Systems [/b]
+
'''Paremeter Estimation of Oscillatory Systems'''
Oscillatory behavior is exhibited by many biological systems. Examples these include the circadian rhythm and p53-mdm2 response to DNA damage. Such dynamical behavior is important and integral of a higher biological function, such as sleeping and feeding patterns (circadian rhythm) and DNA repair (p53-mdm2). To study these systems, in-silico models have been developed to aid in the analysis. However, the corresponding model parameters are usually chosen qualitatively such that the system to exhibit the general characteristics of experimental data. The focus of the research here is to facilitate reconciliation of the model with experimental data in a quantitative manner.
Oscillatory behavior is exhibited by many biological systems. Examples these include the circadian rhythm and p53-mdm2 response to DNA damage. Such dynamical behavior is important and integral of a higher biological function, such as sleeping and feeding patterns (circadian rhythm) and DNA repair (p53-mdm2). To study these systems, in-silico models have been developed to aid in the analysis. However, the corresponding model parameters are usually chosen qualitatively such that the system to exhibit the general characteristics of experimental data. The focus of the research here is to facilitate reconciliation of the model with experimental data in a quantitative manner.

Revision as of 12:22, 17 July 2008

Chemical and Biological Systems Engineering Laboratory

Home                    Research                    People                    Publications                    Internal                    News       


I am a new member of OpenWetWare!

Contact Info

Ang, Kok Siong (an artistic interpretation)
Ang, Kok Siong (an artistic interpretation)
  • Ang, Kok Siong
  • National University of Singapore (NUS)
  • 4 Engineering Drive 4, Blk E5 #B-05, Singapore 117576
  • Singapore
  • Email me through OpenWetWare

I work in the Gunawan Lab at National University of Singapore.

Education

  • Student, M.Eng, NUS
  • 2006, B.Eng, NUS

Research interests

  1. Systems Biology
  2. Control Systems
  3. Global Optimization


Paremeter Estimation of Oscillatory Systems

Oscillatory behavior is exhibited by many biological systems. Examples these include the circadian rhythm and p53-mdm2 response to DNA damage. Such dynamical behavior is important and integral of a higher biological function, such as sleeping and feeding patterns (circadian rhythm) and DNA repair (p53-mdm2). To study these systems, in-silico models have been developed to aid in the analysis. However, the corresponding model parameters are usually chosen qualitatively such that the system to exhibit the general characteristics of experimental data. The focus of the research here is to facilitate reconciliation of the model with experimental data in a quantitative manner.

Publications

  1. []

Useful links

Personal tools