Hartman Behavioral Neuroscience Lab: Difference between revisions
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Our lab at [[Loma Linda University]] in [http://maps.google.com/maps?f=q&hl=en&geocode=&q=loma+linda,+ca&ie=UTF8&t=h&ll=35.245619,-117.246094&spn=8.268015,17.86377&z=6&iwloc=addr southern California] primarily uses animal models to understand | Our lab at [[Loma Linda University]] in [http://maps.google.com/maps?f=q&hl=en&geocode=&q=loma+linda,+ca&ie=UTF8&t=h&ll=35.245619,-117.246094&spn=8.268015,17.86377&z=6&iwloc=addr southern California] primarily uses animal models of neurological disease to understand their mechanisms and potential therapeutic treatments. Techniques used include behavioral assessment (e.g., [[Hartman Behavioral Neuroscience Lab:Protocols |water maze]]) of rats and genetically modified ([http://en.wikipedia.org/wiki/Transgenic transgenic] / [http://en.wikipedia.org/wiki/Knockout_%28genetics%29 knockout]) mice, pharmacology (e.g., manipulation of behavior with various drugs), small animal surgery (e.g., intracardial perfusion, electrolytic brain lesions, induction of ischemic stroke), [http://en.wikipedia.org/wiki/Histology histology] / [http://en.wikipedia.org/wiki/Immunohistochemistry immunohistochemistry] (e.g., visualization of amyloid plaques in brain slices), [http://en.wikipedia.org/wiki/Stereology stereological] microscopy (unbiased quantification of brain structures under a microscope), and [http://en.wikipedia.org/wiki/Biochemistry biochemistry] (e.g., protein assays of brain tissue using [http://en.wikipedia.org/wiki/Western_blot Western blot] and [http://en.wikipedia.org/wiki/ELISA ELISA]). | ||
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Revision as of 13:17, 3 April 2009
Our lab at Loma Linda University in southern California primarily uses animal models of neurological disease to understand their mechanisms and potential therapeutic treatments. Techniques used include behavioral assessment (e.g., water maze) of rats and genetically modified (transgenic / knockout) mice, pharmacology (e.g., manipulation of behavior with various drugs), small animal surgery (e.g., intracardial perfusion, electrolytic brain lesions, induction of ischemic stroke), histology / immunohistochemistry (e.g., visualization of amyloid plaques in brain slices), stereological microscopy (unbiased quantification of brain structures under a microscope), and biochemistry (e.g., protein assays of brain tissue using Western blot and ELISA).
