Harvard:Biophysics 101/2007/04/10

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(Resources for disease frequency)
(What we need)
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**Frequency of deleterious allele
**Frequency of deleterious allele
***[http://www.genecards.org/index.shtml GeneCards]
***[http://www.genecards.org/index.shtml GeneCards]
-
**Clustering alleles for relevance to particular diseases
+
**Clustering alleles with respect to genes and particular diseases
**Treatment
**Treatment
***[http://www.emedicine.com/ Emedicine]
***[http://www.emedicine.com/ Emedicine]

Revision as of 10:27, 10 April 2007

What we have now

  • Sequence
  • RS#
  • OMIM
  • Parsed OMIM output
    • Pubmed - reviews and related articles
    • News (sort good from bad)
    • Wikipedia

What we need

Please sign up for problems below
  • Prioritize RS# - How to quantify the criteria below?
    • Disease relevance
      • Number of PMID's
      • Number of drugs for particular disease
      • Disease lists from WHO - cross ref with pubmed
      • CDC
      • California excel table - frequency of diagnosis
    • Frequency of deleterious allele
    • Clustering alleles with respect to genes and particular diseases
    • Treatment
    • Known alleles
    • Penetrance
  • Web interface
    • Not just script also paste in sequence
    • Maybe useful source for getting sequence data
  • Non OMIM based analysis of sequences

Resources for disease frequency

--Zsun

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