Harvard:Biophysics 101/2007/Notebook:HRH/2007-3-13

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(New page: Link to assignment: http://openwetware.org/wiki/Harvard:Biophysics_101/2007/03/13 ===Task 1=== After running the NCBI Blast, I received the following results: <pre> NT_030059.12 Homo s...)
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Revision as of 15:14, 13 March 2007

Link to assignment:

http://openwetware.org/wiki/Harvard:Biophysics_101/2007/03/13


Task 1

After running the NCBI Blast, I received the following results:

NT_030059.12	Homo sapiens chromosome 10 genomic contig, reference assembly
NW_924884.1	Homo sapiens chromosome 10 genomic contig, alternate assembly (based on Celera assembly)

Additionally, the flanking proteins are:

  • 3895 bp at 5' side: hypothetical protein
  • 425 bp at 3' side: HtrA serine peptidase 1

There is a point mutation at bp 201 (A-T -> A-G).

The reading frame containing the ATG start codon has the mutation changing the amino acid from a CAG to CGG (Glutamine to Arginine). Glutamine is polar and neutral, and Arginine is also polar and strongly basic (they are both hydrophilic).

Laymen's terms: the mutation probably will not do any harm (i.e. don't worry).

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