Harvard:Synthetic Biology Nanocourse/2007

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Intellectual Unit: Experimental Tools for Biological Discovery

Contents

Synthetic Biology: Cellular and Molecular Engineering


Instructors


Course Description

Synthetic biology explores the design rules for building artificial behavior of biomolecular systems through cycles of construction and comparison of intended versus observed behaviors. The ability to synthesize biomimetic behavior is an important benchmark for biological understanding. This course will introduce strategies for engineering cellular and molecular systems and will explore current and future applications for synthetic biology approaches.

Meeting Times

  • First Meeting: Monday, 2007 October 22nd, 1:30pm–4:30pm
    • Location: Goldenson 122 (on the HMS quad)
  • Second Meeting: Friday, 2007 October 26th, 12pm–2pm
    • Location: Warren Alpert Building 436


Course Project


Reading List (Recommended)


Lecture 1 (Silver)

  1. Drubin DA, Way JC, and Silver PA. . pmid:17289915. PubMed HubMed [pas1]
  1. Voigt CA. . pmid:16978856. PubMed HubMed [pas1]
  1. Chang MC and Keasling JD. . pmid:17108985. PubMed HubMed [pas1]
  1. Anderson JC, Clarke EJ, Arkin AP, and Voigt CA. . pmid:16330045. PubMed HubMed [pas1]
  1. Andrianantoandro E, Basu S, Karig DK, and Weiss R. . pmid:16738572. PubMed HubMed [pas1]
  1. Deans TL, Cantor CR, and Collins JJ. . pmid:17662949. PubMed HubMed [pas1]
  1. Ajo-Franklin CM, Drubin DA, Eskin JA, Gee EP, Landgraf D, Phillips I, and Silver PA. . pmid:17875664. PubMed HubMed [pas1]
  1. Basu S, Gerchman Y, Collins CH, Arnold FH, and Weiss R. . pmid:15858574. PubMed HubMed [pas1]
  1. Elowitz MB and Leibler S. . pmid:10659856. PubMed HubMed [pas1]

Drubin DA, Way JC, Silver PA. Designing biological systems. Genes Dev. 2007 Feb 1;21(3):242-54.

Voigt CA.Genetic parts to program bacteria.Curr Opin Biotechnol. 2006 Oct;17(5):548-57. Epub 2006 Sep 15.

Chang MC, Keasling JD.Production of isoprenoid pharmaceuticals by engineered microbes. Nat Chem Biol. 2006 Dec;2(12):674-81

Anderson JC, Clarke EJ, Arkin AP, Voigt CA.Environmentally controlled invasion of cancer cells by engineered bacteria. J Mol Biol. 2006 Jan 27;355(4):619-27. Epub 2005 Nov 14.

Andrianantoandro E, Basu S, Karig DK, Weiss R. Synthetic biology: new engineering rules for an emerging discipline. Mol Syst Biol. 2006;2:2006.0028. Epub 2006 May 16

Deans TL, Cantor CR, Collins JJ. A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells. Cell. 2007 Jul 27;130(2):363-72.

Ajo-Franklin CM, Drubin DA, Eskin JA, Gee EP, Landgraf D, Phillips I, Silver PA. Rational design of memory in eukaryotic cells. Genes Dev. 2007 Sep 15;21(18):2271-6.

Basu S, Gerchman Y, Collins CH, Arnold FH, Weiss R. A synthetic multicellular system for programmed pattern formation. Nature. 2005 Apr 28;434(7037):1130-4.

Elowitz MB, Leibler S.A synthetic oscillatory network of transcriptional regulators. Nature. 2000 Jan 20;403(6767):335-8.

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