Harvard:Synthetic Biology Nanocourse/2007
Intellectual Unit: Experimental Tools for Biological Discovery
Synthetic Biology: Cellular and Molecular Engineering
- Nanocourse Lecturers: George Church (talk), William Shih (talk) (co-director), and Pamela Silver (talk) (co-director)
Synthetic biology explores the design rules for building artificial behavior of biomolecular systems through cycles of construction and comparison of intended versus observed behaviors. The ability to synthesize biomimetic behavior is an important benchmark for biological understanding. This course will introduce strategies for
engineering cellular and molecular systems and will explore current and future applications for synthetic biology approaches.
- First Meeting: Monday, 2007 October 22nd, 1:30pm–4:30pm
- Location: Goldenson 122 (on the HMS quad)
- Second Meeting: Friday, 2007 October 26th, 12pm–2pm
- Location: Warren Alpert Building 436
- For those enrolled in the nanocourse, the course project will be a short proposal (800–1000 words plus figures) describing a synthetic biology project that can be completed by a graduate student in three years or less. The proposals, in Adobe PDF form, must be posted on this wiki page by noon on Thursday, 2007 October 25.
- Registered students and instructors will read the proposals and meet on Friday, 2007 October 26 at noon to critique the proposals (see above).
- To see some potential project ideas, please browse through the project and brainstorming pages of former iGEM teams. If you decide to adopt one of those ideas, you need to propose a significant improvement or alteration that represents value added to the original idea. Be sure to credit the sources for your inspirations. Here are some example links (everyone, please feel free to add more or to reorganize):
Reading List (Recommended)
Lecture 1 (Silver)
The first 3 papers are reviews and are highly recommended as introductory readings. The other papers are examples of designing systems that may be useful background for those taking the course and for further background in the field.
- Drubin DA, Way JC, and Silver PA. . pmid:17289915.
- Voigt CA. . pmid:16978856.
- Andrianantoandro E, Basu S, Karig DK, and Weiss R. . pmid:16738572.
- Chang MC and Keasling JD. . pmid:17108985.
- Anderson JC, Clarke EJ, Arkin AP, and Voigt CA. . pmid:16330045.
- Deans TL, Cantor CR, and Collins JJ. . pmid:17662949.
- Ajo-Franklin CM, Drubin DA, Eskin JA, Gee EP, Landgraf D, Phillips I, and Silver PA. . pmid:17875664.
- Basu S, Gerchman Y, Collins CH, Arnold FH, and Weiss R. . pmid:15858574.
- Elowitz MB and Leibler S. . pmid:10659856.
Lecture 2 (Shih)
Lecture 3 (Church)
Remember to upload a PDF of your file by Thursday, October 25th by noon. Uploading your file on time means that your fellow classmates and instructors can spend more time reading and considering your proposal. Please name your files something meaningful. I suggest the following format... NameofStudent_syntheticbiology2007.