Harvard:Synthetic Biology Nanocourse/2007

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Intellectual Unit: Experimental Tools for Biological Discovery


Synthetic Biology: Cellular and Molecular Engineering


Course Description

Synthetic biology explores the design rules for building artificial behavior of biomolecular systems through cycles of construction and comparison of intended versus observed behaviors. The ability to synthesize biomimetic behavior is an important benchmark for biological understanding. This course will introduce strategies for engineering cellular and molecular systems and will explore current and future applications for synthetic biology approaches.

Meeting Times

  • First Meeting: Monday, 2007 October 22nd, 1:30pm–4:30pm
    • Location: Goldenson 122 (on the HMS quad)
  • Second Meeting: Friday, 2007 October 26th, 12pm–2pm
    • Location: Warren Alpert Building 436

Course Project

Reading List

Lecture 1 (Silver)

The first 3 papers are reviews and are highly recommended as introductory readings. The other papers are examples of designing systems that may be useful background for those taking the course and for further background in the field.

  1. Drubin DA, Way JC, and Silver PA. . pmid:17289915. PubMed HubMed [pas1]
  2. Voigt CA. . pmid:16978856. PubMed HubMed [pas2]
  3. Andrianantoandro E, Basu S, Karig DK, and Weiss R. . pmid:16738572. PubMed HubMed [pas3]
  4. Chang MC and Keasling JD. . pmid:17108985. PubMed HubMed [pas4]
  5. Anderson JC, Clarke EJ, Arkin AP, and Voigt CA. . pmid:16330045. PubMed HubMed [pas5]
  6. Deans TL, Cantor CR, and Collins JJ. . pmid:17662949. PubMed HubMed [pas6]
  7. Ajo-Franklin CM, Drubin DA, Eskin JA, Gee EP, Landgraf D, Phillips I, and Silver PA. . pmid:17875664. PubMed HubMed [pas7]
  8. Basu S, Gerchman Y, Collins CH, Arnold FH, and Weiss R. . pmid:15858574. PubMed HubMed [pas8]
  9. Elowitz MB and Leibler S. . pmid:10659856. PubMed HubMed [pas9]
All Medline abstracts: PubMed HubMed

Lecture 2 (Shih)

  1. []

Lecture 3 (Church)

  1. []

Uploaded Proposals

Remember to upload a PDF of your file by Thursday, October 25th by noon. Uploading your file on time means that your fellow classmates and instructors will have ample time to carefully read all of the proposals. Please name your files something meaningful. I suggest the following format... NameofStudent_syntheticbiology2007.

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