Haynes:LitRviewMar2012
Spring 2012, 3/30/12
ACS Synthetic Biology
1. Evan Mills, Xi Chen, Elizabeth Pham, Stanley Wong, and Kevin Truong et al (2011). Engineering a Photoactivated Caspase-7 for Rapid Induction of Apoptosis. ACS Synthetic Biology 2012 1 (3) Summary: Group from University of Toronto developed protein that causes rapid cell apotosis (cell death) of targeted cells. 2.
FEBS Letters
1. Kono H, Imanishi M, Negi S, Tatsutani K, Sakaeda Y, et al. (2012). Rational design of DNA sequence-specific zinc fingers. FEBS letters. 586: 918–923. Link
Summary: Sugiura's group from Kyoto, Japan mutated zinc finger DNA binding domains to increase binding affinity.
Frontiers in Microbiotechnology
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Journal of Biological Engineering
1. Joshua T Kittleson, Sherine Cheung, and J Christopher Anderson, Rapid optimization of gene dosage in E. coli using DIAL strains. Journal of Biological Engineering. ,2011 Link
Summary: In an attempt to simplify the tuning process of synthetically created E. coli the author has created a system to test multiple copy numbers.
2. Lorenzo Pasotti1, Susanna Zucca1, Manuel Lupotto, Maria Gabriella Cusella De Angelis and Paolo Magni, Characterization of a synthetic bacterial selfdestruction device for programmed cell death and for recombinant proteins release. Journal of Biological Engineering. ,2011 Link
Summary: This paper characterizes the destructive properties of the BioBrick BBa_K112808.
3. Michael A Speer and Tom L Richard, Amplified insert assembly: an optimized approach to standard assembly of BioBrickTM genetic circuits. , 2011. Link
Summary: A new system of assembling BioBricks using primers and PCR.
Journal of Cell Biology
1. Yejing Ge, Yuting Sun, and J. Chencorresponding, IGF-II is regulated by microRNA-125b in skeletal myogenesis. J Cell Biol. , 2011. 192(1): p. 69-81. Summary: IGF-II (insulin-like growth factor 2), a critical regulator of skeletal myogenesis, as a direct and major target of miR-125b in both myocytes and regenerating muscles, This article revealing for the first time an miRNA mechanism controlling IGF-II expression.
2. Suzanne Hoppins, et al., A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J. Cell Biol., 2011. 195(2): p. 323–340. Summary: They constructed a quantitative, high-density genetic interaction map in Saccharomyces cerevisiae to explore mitochondrial structure and function as well as the communication of mitochondria with other cellular pathways.
3. Haynes, K.A. and P.A. Silver, Eukaryotic systems broaden the scope of synthetic biology. J. Cell Biol., 2009. 187(5): p. 589–596.Summary: This review surveys recent advances in eukaryotic synthetic biology and describes how synthetic systems can be linked to natural cellular processes in order to manipulate cell behavior and to foster new discoveries in cell biology research.
Molecular Biology of the Cell
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Molecular and Cellular Biology
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Nature
1. Dana GV, Kuiken T, Rejeski D, Snow A. (2012). Four steps to avoid a synthetic-biology disaster. Nature. 483: 29. Link
Summary: A group from the Synthetic Biology project at the Woodrow Wilson Institute suggests four key areas for testing and determining the safety of synthetic organisms.
Nature Biotechnology
1. Yizhi Cai & Jef D Boeke, Genome remodeling. , 2011. Link
Summary: Alter the stop codon of E. coli.
PLoS Biology
1. Levine JH, Fontes ME., Dworkin J, Elowitz, MB (2012). Pulsed feedback defers cellular differentiation. PLoS Biology, 10(1) Link
Summary: The Elowitz lab from Cal Tech reports a mechanism underlying a biological timer in bacteria (Bacillus subtilis).
2. Nishida K, Silver PA. (2012). Induction of biogenic magnetization and redox control by a component of the target of rapamycin complex 1 signaling pathway. PLoS Biology. 10(2) Link
Summary: The Silver lab from Harvard reports genetic manipulation of yeast to make it accumulate more magnetic iron (Fe3+) and display enhanced magnetic properties. There's a very good blog article on this project at the Scientific American.
Systems and Synthetic Biology
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