Haynes Lab: Difference between revisions
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'''Synthetic chromatin for cancer research''' | '''Synthetic chromatin for cancer research''' | ||
* David Nyer (Research Tech), David Tze (Biomed Eng. BS) | * David Nyer (Research Tech), Daniel Vargas (Biological Design PhD), Stefan Tekel (Biological Design PhD), David Tze (Biomed Eng. BS) | ||
* Description: Using the "PcTF" synthetic chromatin protein/ transcription activator described in [http://www.ncbi.nlm.nih.gov/pubmed/21669865 Haynes & Silver 2011] to regulate genes in cancer cells. Building and testing re-engineered versions of PcTF. | * Description: Using the "PcTF" synthetic chromatin protein/ transcription activator described in [http://www.ncbi.nlm.nih.gov/pubmed/21669865 Haynes & Silver 2011] to regulate genes in cancer cells. Building and testing re-engineered versions of PcTF. | ||
'''Opening silenced chromatin''' | '''Opening silenced chromatin''' | ||
* | * René Daer (Biological Design, PhD), Cassandra Barrett (Biological Design, PhD) | ||
* Description: Using synthetic chromatin proteins to induce a permanently re-opened state at epigenetically silenced genes. | * Description: Using synthetic chromatin proteins to induce a permanently re-opened state at epigenetically silenced genes. | ||
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* David Barclay (Biomedical Eng. BS), Jan Simper (Biomedical Eng. BS), Theodore Kyriacou (Biomedical Eng. BS) | * David Barclay (Biomedical Eng. BS), Jan Simper (Biomedical Eng. BS), Theodore Kyriacou (Biomedical Eng. BS) | ||
* Description: Designing a single-cell-level fluorescent reporter that tracks changes in epigenetic states in developing cells. | * Description: Designing a single-cell-level fluorescent reporter that tracks changes in epigenetic states in developing cells. | ||
'''Microbial communication with synthetic quorum sensing''' | '''Microbial communication with synthetic quorum sensing''' | ||
* René | * René Daer (Biological Design, PhD), Ryan Muller (Biochem. BS), Jiaqi Wu (Biomedical Eng. BS) | ||
* Description: Characterizing cross-talk between decoupled cell-cell communication systems from bacteria. | * Description: Characterizing cross-talk between decoupled cell-cell communication systems from bacteria. | ||
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'''Lab Notebooks - Active''' {{hide| | '''Lab Notebooks - Active''' {{hide| | ||
* [http://openwetware.org/wiki/User:David_Benjamin_Nyer/Notebook Ben] | * [http://openwetware.org/wiki/User:David_Benjamin_Nyer/Notebook Ben] | ||
* [http://openwetware.org/wiki/ | * [http://openwetware.org/wiki/User:Daniel_A._Vargas/Notebook/General_lab_notebook Daniel] | ||
* [http://openwetware.org/wiki/User:David_Barclay/Notebook David Barclay] | * [http://openwetware.org/wiki/User:David_Barclay/Notebook David Barclay] | ||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Synthetic_Chromatin_for_Cancer_Research David Tze] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Jan Jan] | * [http://openwetware.org/wiki/Haynes_Lab:Notebook/Jan Jan] | ||
* [http://openwetware.org/wiki/User:Karmella_Haynes/Notebook Karmella] | * [http://openwetware.org/wiki/User:Karmella_Haynes/Notebook Karmella] | ||
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* [http://openwetware.org/wiki/Haynes_Lab:Notebook:Shared/Cloning_Bootcamp SHARED: Cloning Bootcamp] | * [http://openwetware.org/wiki/Haynes_Lab:Notebook:Shared/Cloning_Bootcamp SHARED: Cloning Bootcamp] | ||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Short_Projects SHARED: Short Projects] | * [http://openwetware.org/wiki/Haynes_Lab:Notebook/Short_Projects SHARED: Short Projects] | ||
* [http://openwetware.org/wiki/User:Stefan_J._Tekel/Notebook/Pc-TF_Engineering Stefan Tekel] | |||
* [http://openwetware.org/wiki/User:Mara_Peterson/Notebook/Mara_Peterson Mara Peterson] | |||
}} | }} | ||
'''Lab Notebooks - Archived''' {{hide| | '''Lab Notebooks - Archived''' {{hide| | ||
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* [http://openwetware.org/wiki/User:Behzad_Damadzadeh/Notebook/PcTF_Subcloning_in_E-coli Behzad] | * [http://openwetware.org/wiki/User:Behzad_Damadzadeh/Notebook/PcTF_Subcloning_in_E-coli Behzad] | ||
* [http://openwetware.org/wiki/User:Brendan_F._Fries/Notebook/Brendan_Fries Brendan] | * [http://openwetware.org/wiki/User:Brendan_F._Fries/Notebook/Brendan_Fries Brendan] | ||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Engineering_PC-TFs Cameron] | |||
* [http://openwetware.org/wiki/Carly's_Lab_Notebook Carly] | * [http://openwetware.org/wiki/Carly's_Lab_Notebook Carly] | ||
* [http://openwetware.org/wiki/User:David_Dreher/Notebook/Chromatin_controlled_cell_pattern David Dreher] | * [http://openwetware.org/wiki/User:David_Dreher/Notebook/Chromatin_controlled_cell_pattern David Dreher] | ||
Latest revision as of 10:44, 7 January 2016
Our group uses synthetic, systems, and quantitative biology to engineer useful gene and protein-based biological devices and to deepen our understanding of molecular cell biology. We operate biological devices primarily in human/ mammalian cells. Accelerating the pace of therapeutic technologies (such as tissue regeneration and customizable protein-based drugs) via modular design is the grand challenge that shapes our research plans.
CURRENT SYNTHETIC BIOMEDICAL ENGINEERING PROJECTS
Synthetic chromatin for cancer research
- David Nyer (Research Tech), Daniel Vargas (Biological Design PhD), Stefan Tekel (Biological Design PhD), David Tze (Biomed Eng. BS)
- Description: Using the "PcTF" synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011 to regulate genes in cancer cells. Building and testing re-engineered versions of PcTF.
Opening silenced chromatin
- René Daer (Biological Design, PhD), Cassandra Barrett (Biological Design, PhD)
- Description: Using synthetic chromatin proteins to induce a permanently re-opened state at epigenetically silenced genes.
Synthetic chromatin systems for cell development
- David Barclay (Biomedical Eng. BS), Jan Simper (Biomedical Eng. BS), Theodore Kyriacou (Biomedical Eng. BS)
- Description: Designing a single-cell-level fluorescent reporter that tracks changes in epigenetic states in developing cells.
Microbial communication with synthetic quorum sensing
- René Daer (Biological Design, PhD), Ryan Muller (Biochem. BS), Jiaqi Wu (Biomedical Eng. BS)
- Description: Characterizing cross-talk between decoupled cell-cell communication systems from bacteria.
Lab Notebooks - Active
Lab Notebooks - Archived
