Haynes Lab: Difference between revisions
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CURRENT SYNTHETIC BIOMEDICAL ENGINEERING PROJECTS<br> | CURRENT SYNTHETIC BIOMEDICAL ENGINEERING PROJECTS<br> | ||
'''Synthetic chromatin for | '''Synthetic chromatin for cancer research''' | ||
* David | * David Nyer (Research Tech), David Tze (Biomed Eng. BS) | ||
* Description: | * Description: Using the "PcTF" synthetic chromatin protein/ transcription activator described in [http://www.ncbi.nlm.nih.gov/pubmed/21669865 Haynes & Silver 2011] to regulate genes in cancer cells. Building and testing re-engineered versions of PcTF. | ||
''' | '''Opening silenced chromatin''' | ||
* | * Daniel Vargas (Biological Design PhD) | ||
* Description: | * Description: Using synthetic chromatin proteins to induce a permanently re-opened state at epigenetically silenced genes. | ||
'''Synthetic chromatin systems for cell development''' | |||
* David Barclay (Biomedical Eng. BS), Jan Simper (Biomedical Eng. BS), Theodore Kyriacou (Biomedical Eng. BS) | |||
* Description: Designing a single-cell-level fluorescent reporter that tracks changes in epigenetic states in developing cells. | |||
''' | '''Editing synthetic genes using CRISPR''' | ||
* | * René Davis (Biological Design PhD) | ||
* Description: | * Description: Characterizing chromatin/CRISPR interactions. | ||
'''Microbial communication with synthetic quorum sensing''' | '''Microbial communication with synthetic quorum sensing''' | ||
* René Davis (Biological Design, PhD), Ryan Muller ( | * René Davis (Biological Design, PhD), Ryan Muller (Biochem. BS), Jiaqi Wu (Biomedical Eng. BS) | ||
* Description: Characterizing cross-talk between decoupled cell-cell communication systems from bacteria. | * Description: Characterizing cross-talk between decoupled cell-cell communication systems from bacteria. | ||
Revision as of 13:37, 15 May 2015
Our group uses synthetic, systems, and quantitative biology to engineer useful gene and protein-based biological devices and to deepen our understanding of molecular cell biology. We operate biological devices primarily in human/ mammalian cells. Accelerating the pace of therapeutic technologies (such as tissue regeneration and customizable protein-based drugs) via modular design is the grand challenge that shapes our research plans.
CURRENT SYNTHETIC BIOMEDICAL ENGINEERING PROJECTS
Synthetic chromatin for cancer research
- David Nyer (Research Tech), David Tze (Biomed Eng. BS)
- Description: Using the "PcTF" synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011 to regulate genes in cancer cells. Building and testing re-engineered versions of PcTF.
Opening silenced chromatin
- Daniel Vargas (Biological Design PhD)
- Description: Using synthetic chromatin proteins to induce a permanently re-opened state at epigenetically silenced genes.
Synthetic chromatin systems for cell development
- David Barclay (Biomedical Eng. BS), Jan Simper (Biomedical Eng. BS), Theodore Kyriacou (Biomedical Eng. BS)
- Description: Designing a single-cell-level fluorescent reporter that tracks changes in epigenetic states in developing cells.
Editing synthetic genes using CRISPR
- René Davis (Biological Design PhD)
- Description: Characterizing chromatin/CRISPR interactions.
Microbial communication with synthetic quorum sensing
- René Davis (Biological Design, PhD), Ryan Muller (Biochem. BS), Jiaqi Wu (Biomedical Eng. BS)
- Description: Characterizing cross-talk between decoupled cell-cell communication systems from bacteria.
Lab Notebooks - Active
Lab Notebooks - Archived
