Haynes Lab: Difference between revisions
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'''Synthetic chromatin for cell differentiation''' | '''Synthetic chromatin for cell differentiation''' | ||
* David Barclay (FURI, BS) - pancreas, Jan Simper (FURI, BS) - cardiac | * David Barclay (FURI & SynBERC, BS) - pancreas, Jan Simper (FURI, BS) - cardiac | ||
* Description: Testing the synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011 to | * Description: Testing the "PcTF" synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011 to determine its ability to alter the phenotypes of healthy cells, such as pancreas beta cells and iPSC's. | ||
'''Editing synthetic genes using CRISPR''' | '''Editing synthetic genes using CRISPR''' | ||
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* '''Engineering synthetic chromatin transcription factors''' | * '''Engineering synthetic chromatin transcription factors''' | ||
* '''Microbial communication with synthetic quorum sensing''' | * Cameron Gardner (FURI, BS) | ||
* Description: Building and testing re-engineered versions of the "PcTF" synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011 | |||
* '''Microbial communication with synthetic quorum sensing''' | |||
* René Davis (Biological Design, PhD), Ryan Muller (SOLUR) | |||
</div> | </div> | ||
Revision as of 15:41, 13 November 2014
Our group uses synthetic, systems, and quantitative biology to engineer useful gene and protein-based biological devices and to deepen our understanding of molecular cell biology. We operate biological devices primarily in human/ mammalian cells. Accelerating the pace of therapeutic technologies (such as tissue regeneration and customizable protein-based drugs) via modular design is the grand challenge that shapes our research plans.
CURRENT PROJECTS
Synthetic chromatin for cell differentiation
- David Barclay (FURI & SynBERC, BS) - pancreas, Jan Simper (FURI, BS) - cardiac
- Description: Testing the "PcTF" synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011 to determine its ability to alter the phenotypes of healthy cells, such as pancreas beta cells and iPSC's.
Editing synthetic genes using CRISPR
- René Davis (Biological Design, PhD)
- Description:
- Engineering synthetic chromatin transcription factors
- Cameron Gardner (FURI, BS)
- Description: Building and testing re-engineered versions of the "PcTF" synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011
- Microbial communication with synthetic quorum sensing
- René Davis (Biological Design, PhD), Ryan Muller (SOLUR)
Lab Notebooks - Active
Lab Notebooks - Archived
