Haynes Lab
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Our group uses synthetic, systems, and quantitative biology to engineer useful gene and protein-based biological devices and to deepen our understanding of molecular cell biology. We operate biological devices primarily in human/ mammalian cells. Accelerating the pace of therapeutic technologies (such as tissue regeneration and customizable protein-based drugs) via modular design is the grand challenge that shapes our research plans.
CURRENT PROJECTS
Synthetic chromatin for cell differentiation
- David Barclay (FURI, BS) - pancreas, Jan Simper (FURI, BS) - cardiac
- Description: Testing the synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011 to assess its ability to alter the phenotypes of healthy cells, such as pancreas beta cells and iPSC's.
Editing synthetic genes using CRISPR
- René Davis (Biological Design, PhD)
- Description:
- Engineering synthetic chromatin transcription factors - Cameron Gardner (FURI)
- Microbial communication with synthetic quorum sensing - René Davis, Ryan Muller (SOLUR)
Lab Notebooks - Active
Lab Notebooks - Archived
