Haynes Lab:Notebook/Engineering PC-TFs

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Project Description/Abstract

  • Synthetic biology is an exciting new field that aims to create

novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

Notes

  • Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University


Recent changes

18 April 2014

+      23:32 Haynes Lab:Notebook/Engineering PC-TFs/2014/04/18‎ (6 changes) . . (+286) . . (Page history) [Cameron Lee Gardner‎ (6×)]
+ N    21:15 Haynes Lab:Notebook/Engineering PC-TFs/2014/04/08‎ (4 changes) . . (+2,665) . . (Page history) [Cameron Lee Gardner‎ (4×)]


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