Haynes Lab:Notebook/James Alling/2013/01/08
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Chromatin is an ancient innovation conserved between Archaea and Eukarya. Ammar R, Torti D, Tsui K, Gebbia M, Durbic T, Bader GD, Giaever G, Nislow C.
Ammar et al. point out that chromatin architecture is conserved between Archaea and Eukarya. This suggests that chromatin structure in the genomes existed long ago in the evolutionary time scale.
Impact: I'm interested in what "advantage" chromatin architecture gave organisms; how did this emerge as as a trait? Does this play a role in more complicated patterning or growth that enabled a more advanced organism structures.
Also, can chromatin be engineered by directed evolution? (at extreme levels of population?)
Favorite quote - ". . . suggesting that the fundamental role of chromatin in the regulation of gene expression is ancient."