Haynes Lab:Notebook/Synthetic Biology and Bioinformatics for Predictable Control of Therapeutic Gene2/2012/11/16: Difference between revisions
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|style="background-color: #EEE"|[[Image:owwnotebook_icon.png|128px]]<span style="font-size:22px;"> Project name</span> | |style="background-color: #EEE"|[[Image:owwnotebook_icon.png|128px]]<span style="font-size:22px;"> Project name</span> | ||
|style="background-color: #F2F2F2" align="center"| | |style="background-color: #F2F2F2" align="center"|[[File:Report.png|frameless|link={{#sub:{{FULLPAGENAME}}|0|-11}}]][[{{#sub:{{FULLPAGENAME}}|0|-11}}|Main project page]]<br />{{#if:{{#lnpreventry:{{FULLPAGENAME}}}}|[[File:Resultset_previous.png|frameless|link={{#lnpreventry:{{FULLPAGENAME}}}}]][[{{#lnpreventry:{{FULLPAGENAME}}}}{{!}}Previous entry]] }}{{#if:{{#lnnextentry:{{FULLPAGENAME}}}}|[[{{#lnnextentry:{{FULLPAGENAME}}}}{{!}}Next entry]][[File:Resultset_next.png|frameless|link={{#lnnextentry:{{FULLPAGENAME}}}}]]}} | ||
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| colspan="2"| | | colspan="2"| | ||
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'''K562''' | '''K562''' | ||
<br/> | <br/> | ||
'' | ''MAP Kinase Activity'' | ||
<br/> | <br/> | ||
1. MAPK14 | 1. MAPK14 | ||
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3. MAPK10 | 3. MAPK10 | ||
*Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis | *Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis | ||
'' | ''Phosphotransferase activity, alcohol group as acceptor'' | ||
<br/> | <br/> | ||
4. RET | 4. RET | ||
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5. FGFR4 | 5. FGFR4 | ||
*This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. | *This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. | ||
6. | 6. CDKN1A | ||
*The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. | *The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. | ||
*The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. | *The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. | ||
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'''SK-N-SH RA''' | '''SK-N-SH RA''' | ||
<br/> | <br/> | ||
'' | ''Signaling receptor activity'' | ||
<br/> | <br/> | ||
1. KIT | 1. KIT |
Latest revision as of 22:16, 26 September 2017
Project name | Main project page Previous entry Next entry |
Genes of FocusThere is a threshold of > 10^-3
K562
2. MAPK9
3. MAPK10
Phosphotransferase activity, alcohol group as acceptor
5. FGFR4
6. CDKN1A
SK-N-SH RA
2. TNFRSF11A
3. EGFR
Sequence-Specific DNA Binding
5. HLF
6. BCL6
|