Haynes Lab:Notebook/Synthetic Biology and Bioinformatics for Predictable Control of Therapeutic Gene2/2012/11/16

(Difference between revisions)

Revision as of 12:58, 16 November 2012

Project name

HepG2

K562
All of these genes are listed under MAP Kinase Activity
1. MAPK14

The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

2. MAPK9

Involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway
This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells

3. MAPK10

Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis

Under phosphotransferase activity, alcohol group as acceptor

Interesting Note: RET is present within the list, a proto-oncogene. It can undergo oncogenic activation and become tumor-inducing.

SK-N-SH RA

@@ Line 12: / Line 12: @@
 <br/>
 All of these genes are listed under MAP Kinase Activity
+<br/>
 . MAPK14
 *The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.