Haynes Lab:Notebook/Synthetic Biology and Bioinformatics for Predictable Control of Therapeutic Gene2/2012/11/16: Difference between revisions
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5. FGFR4 | 5. FGFR4 | ||
*This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. | *This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. | ||
6. | 6. CDKN1A | ||
*The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. | *The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. | ||
*The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. | *The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. |
Revision as of 21:46, 24 November 2012
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Genes of FocusThere is a threshold of > 10^-3
K562
2. MAPK9
3. MAPK10
Phosphotransferase activity, alcohol group as acceptor
5. FGFR4
6. CDKN1A
SK-N-SH RA
2. TNFRSF11A
3. EGFR
Sequence-Specific DNA Binding
5. HLF
6. BCL6
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