Haynes Lab:Notebook/Synthetic Biology and Bioinformatics for Predictable Control of Therapeutic Gene2/2013/01/25: Difference between revisions
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#EPHB2: Prognostic factor in colorectal cancer. Expression is significantly higher in NSCLC tissue than in control tissues, and were positively correlated with lymphatic metastasis. Expression has closed related to gennesis and progression of hepatoblastoma. | #EPHB2: Prognostic factor in colorectal cancer. Expression is significantly higher in NSCLC tissue than in control tissues, and were positively correlated with lymphatic metastasis. Expression has closed related to gennesis and progression of hepatoblastoma. | ||
#PBK: PBK/TOPK (PDZ-binding kinase, T-LAK-cell-originated protein kinase) is a serine-threonine kinase that is overexpressed in a variety of tumor cells. | |||
''Protein Kinase Activity'' | ''Protein Kinase Activity'' | ||
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#SLC4A7: associated with increased risk of breast cancer | #SLC4A7: associated with increased risk of breast cancer | ||
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#CHRNA3: Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. | #CHRNA3: Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. | ||
#EPBH4: Expression is significantly higher in NSCLC tissue than in control tissues, and were positively correlated with lymphatic metastasis. EphB4 plays an important role in the progression of papillary thyroid carcinoma by stimulating cell migration and EphB4 might be a potential therapeutic target in papillary thyroid carcinoma. EphB4 protein expression is significantly increased in non-small- cell lung cancer and corresponds to progression and severity of the disease. Expression has closed related to gennesis and progression of hepatoblastoma. Observed as being significantly related to tumor size and regional lymph nodes category. | #EPBH4: Expression is significantly higher in NSCLC tissue than in control tissues, and were positively correlated with lymphatic metastasis. EphB4 plays an important role in the progression of papillary thyroid carcinoma by stimulating cell migration and EphB4 might be a potential therapeutic target in papillary thyroid carcinoma. EphB4 protein expression is significantly increased in non-small- cell lung cancer and corresponds to progression and severity of the disease. Expression has closed related to gennesis and progression of hepatoblastoma. Observed as being significantly related to tumor size and regional lymph nodes category. | ||
#IL13RA1: cancer/testis antigen | |||
''signal transducer activity'' | ''signal transducer activity'' | ||
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''growth factor activity'' | ''growth factor activity'' | ||
#KITLG: Linked to predisposing testicular germ cell cancer. | #KITLG: Linked to predisposing testicular germ cell cancer. | ||
#IGF2: It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. | |||
''receptor binding'' | ''receptor binding'' | ||
#FGF4: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. | #FGF4: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. | ||
#IL1B: inflammatory cytokines IL1B is shown to contribute to breast cancer development and metastasis | #IL1B: inflammatory cytokines IL1B is shown to contribute to breast cancer development and metastasis | ||
#BMP4: Upregulation of bone morphogenetic protein 4 is associated with hepatocellular carcinoma. | |||
''sequence-specific DNA binding transcription factor activity'' | ''sequence-specific DNA binding transcription factor activity'' | ||
#MYCL1: v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived | #MYCL1: v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived | ||
# | ''transporter activity'' | ||
# | #STEAP2: Increased transcriptional expression of the human gene is associated with prostate cancer progression. | ||
''oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen'' | |||
#CYP2A6: Cytochrome P450 2A6 (CYP2A6) is an enzyme responsible for the metabolism of nicotine and some tobacco-specific carcinogens (such as N-nitrosamines). CYP2A6 genetic variations are associated with the activity of the CYP2A6 enzyme, which affects smoking behavior and the rate at which some tobacco-specific carcinogens are metabolized, which in turn determines the incidence of lung cancer. | |||
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Revision as of 03:47, 1 February 2013
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Gene Expression Round 2K562
phosphotransferase activity, alcohol group as acceptor
structural molecule activity
Protein Kinase Activity
structural molecule activity
anion transmembrane transporter activity
SK-N-SH
signal transducer activity
sequence-specific DNA binding
G-protein coupled receptor activity
sequence-specific DNA binding transcription factor activity
transmembrane transporter activity
growth factor activity
receptor binding
sequence-specific DNA binding transcription factor activity
transporter activity
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