Recent Publications
2012
Velma, V., Broome, H.J., and Hebert, M.D. (2012). Regulated specific proteolysis of the Cajal body marker protein coilin. Chromosoma. [1]
Velma, V., Carrero, Z.I., Allen, C.B., and Hebert, M.D. (2012). Coilin levels modulate cell cycle progression and γH2AX levels in etoposide treated U2OS cells. FEBS letters. [2]
Broome HJ, Hebert MD (2012) In Vitro RNase and Nucleic Acid Binding Activities Implicate Coilin in U snRNA Processing. PLoS ONE 7(4): e36300. [3]
2011
Carrero ZI, Velma V, Douglas HE, Hebert MD (2011) Coilin phosphomutants disrupt cajal body formation, reduce cell proliferation and produce a distinct coilin degradation product. PLoS One 6: e25743. [4]
Gilder AS, Do PM, Carrero ZI, Cosman AM, Broome HJ, Velma V, Martinez LA, Hebert MD.
Coilin participates in the suppression of RNA polymerase I in response to cisplatin
induced DNA damage. Mol Biol Cell. 2011 Feb 2. [Epub ahead of print]. PMID: 21289084 [5]
[6]
2010
Velma V., Carrero Z., Cosman M., Hebert M.D. Coilin interacts with Ku proteins
and inhibits in vitro non-homologous DNA end joining. FEBS Lett. 2010 Dec 1;584(23):4735-9.PMID: 21070772 [7]
Hebert MD. Phosphorylation and the Cajal body: modification in search of
function. Arch Biochem Biophys. 2010 Apr 15;496(2):69-76. Epub 2010 Mar 1.
Review. PubMed PMID: 20193656; PubMed Central PMCID: PMC2850958.
Bidwell GL 3rd, Whittom AA, Thomas E, Lyons D, Hebert MD, Raucher D. A
thermally targeted peptide inhibitor of symmetrical dimethylation inhibits
cancer-cell proliferation. Peptides. 2010 May;31(5):834-41. Epub 2010 Feb 16.
PubMed PMID: 20167239; PubMed Central PMCID: PMC2872552.
Toyota CG, Davis MD, Cosman AM, Hebert MD. Coilin phosphorylation mediates
interaction with SMN and SmB'. Chromosoma. 2010 Apr;119(2):205-15. Epub 2009 Dec
8. PubMed PMID: 19997741; PubMed Central PMCID: PMC2839002. [8]
2009
Hearst SM, Gilder AS, Negi SS, Davis MD, George EM, Whittom AA, Toyota CG,
Husedzinovic A, Gruss OJ, Hebert MD. Cajal-body formation correlates with
differential coilin phosphorylation in primary and transformed cell lines. J Cell
Sci. 2009 Jun 1;122(Pt 11):1872-81. Epub 2009 May 12. PubMed PMID: 19435804;
PubMed Central PMCID: PMC2684838. [9]
2008
Whittom AA, Xu H, Hebert MD. Coilin levels and modifications influence
artificial reporter splicing. Cell Mol Life Sci. 2008 Apr;65(7-8):1256-71. PubMed
PMID: 18322647.
Hebert MD. Targeting the gene in Friedreich ataxia. Biochimie. 2008
Aug;90(8):1131-9. Epub 2007 Dec 28. Review. PubMed PMID: 18206656.
2007
Hebert MD, Whittom AA. Gene-based approaches toward Friedreich ataxia
therapeutics. Cell Mol Life Sci. 2007 Dec;64(23):3034-43. Review. PubMed PMID:
17828464.
Sun J, Xu H, Negi S, Subramony SH, Hebert MD. Differential effects of
polyglutamine proteins on nuclear organization and artificial reporter splicing.
J Neurosci Res. 2007 Aug 15;85(11):2306-17. PubMed PMID: 17526020.
Vig PJ, Wei J, Shao Q, Hebert MD, Subramony SH, Sutton LT. Role of tissue
transglutaminase type 2 in calbindin-D28k interaction with ataxin-1. Neurosci
Lett. 2007 Jun 8;420(1):53-7. Epub 2007 Apr 5. PubMed PMID: 17442486; PubMed
Central PMCID: PMC1949022.
2006
D'Souza DR, Wei J, Shao Q, Hebert MD, Subramony SH, Vig PJ. Tissue
transglutaminase crosslinks ataxin-1: possible role in SCA1 pathogenesis.
Neurosci Lett. 2006 Nov 27;409(1):5-9. Epub 2006 Oct 11. PubMed PMID: 17045396;
PubMed Central PMCID: PMC2117902.
Grant L, Sun J, Xu H, Subramony SH, Chaires JB, Hebert MD. Rational selection
of small molecules that increase transcription through the GAA repeats found in
Friedreich's ataxia. FEBS Lett. 2006 Oct 2;580(22):5399-405. Epub 2006 Sep 15.
PubMed PMID: 16989817; PubMed Central PMCID: PMC1847611.
2005
Sun J, Xu H, Subramony SH, Hebert MD. Interactions between coilin and PIASy
partially link Cajal bodies to PML bodies. J Cell Sci. 2005 Nov 1;118(Pt
21):4995-5003. Epub 2005 Oct 11. PubMed PMID: 16219678.
Xu H, Somers ZB, Robinson ML 2nd, Hebert MD. Tim50a, a nuclear isoform of the
mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis. BMC
Cell Biol. 2005 Jul 11;6(1):29. PubMed PMID: 16008839; PubMed Central PMCID:
PMC1177934.
Xu H, Pillai RS, Azzouz TN, Shpargel KB, Kambach C, Hebert MD, Schümperli D,
Matera AG. The C-terminal domain of coilin interacts with Sm proteins and U
snRNPs. Chromosoma. 2005 Aug;114(3):155-66. Epub 2005 Jul 8. PubMed PMID:
16003501; PubMed Central PMCID: PMC1389727.
Xu H, Hebert MD. A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the
Cajal body protein coilin. BMC Cell Biol. 2005 Apr 29;6(1):23. PubMed PMID:
15862129; PubMed Central PMCID: PMC1097723.
2004
Dundr M, Hebert MD, Karpova TS, Stanek D, Xu H, Shpargel KB, Meier UT,
Neugebauer KM, Matera AG, Misteli T. In vivo kinetics of Cajal body components. J
Cell Biol. 2004 Mar 15;164(6):831-42. PubMed PMID: 15024031; PubMed Central
PMCID: PMC1630494.
