Hebert:Research: Difference between revisions
From OpenWetWare
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (10 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
<div style="padding: 2px; color: #xxxxxx; background-color: #997; width: 1130px"> | |||
<center> | <center> | ||
[[Hebert | <font face="trebuchet ms" style="color:# | |||
[[Hebert:Contact | <font face="trebuchet ms" style="color:# | <font size="4">[[Hebert Lab | <font face="trebuchet ms" style="color:#xxxxxx"> '''Home''' </font>]] | ||
[[Hebert: | [[Hebert:Contact | <font face="trebuchet ms" style="color:#xxxxxx"> '''Contact''' </font>]] | ||
[[Hebert: | [[Hebert:Lab Members | <font face="trebuchet ms" style="color:#xxxxxx"> '''Lab Members''' </font>]] | ||
[[Hebert: | [[Hebert:Publications | <font face="trebuchet ms" style="color:#xxxxxx"> '''Publications''' </font>]] | ||
[[Hebert: | [[Hebert:Research | <font face="trebuchet ms" style="color:#xxxxxx"> '''Research''' </font>]] | ||
[[Hebert:Lab pictures | <font face="trebuchet ms" style="color:#xxxxxx"> '''Lab Pictures''' </font>]] </font> | |||
<div style="text-align: center; "> | |||
<div style="margin-bottom: 0px; margin-left: auto; margin-right: auto; margin-top: 0px; overflow: hidden; position: relative; word-wrap: break-word; background: rgb(213, 212, 169); text-align: left; width: 800px; " id="body_content"> | |||
<div style="float: left; height: 0px; line-height: 0px; margin-left: 0px; position: relative; width: 800px; z-index: 10; " id="header_layer"> | |||
<div style="height: 0px; line-height: 0px; " class="bumper"> </div> | |||
</div> | |||
<div style="margin-left: 0px; position: relative; width: 800px; z-index: 0; " id="nav_layer"> | |||
<div style="height: 0px; line-height: 0px; " class="bumper"> </div> | |||
<div class="com-apple-iweb-widget-navbar flowDefining" id="widget0" style="margin-left: 85px; margin-top: 0px; opacity: 1.00; position: relative; width: 630px; z-index: 1; "> | |||
<div id="widget0-navbar" class="navbar"> | |||
<div id="widget0-bg" class="navbar-bg"> | |||
Our work seeks to understand nuclear function, with particular emphasis on splicing and transcription efficiency. | Our work seeks to understand nuclear function, with particular emphasis on splicing and transcription efficiency. | ||
| Line 31: | Line 45: | ||
We are also conducting experiments designed to understand the normal cellular dialogue that occurs between some subnuclear domains. For example, it has been known for some time that Cajal bodies and another nuclear structure, known as the PML body, occasionally abut one another. We have found that CBs and PML bodies can simultaneously associate near U2 snRNA gene loci. It is possible that such an arrangement facilitates the transcription of this gene and experiments are underway to confirm this hypothesis. Additionally, since Cajal bodies are especially prevalent in cancer cells, identification and characterization of proteins that induce the formation of this structure may lead to novel cancer therapeutics. | We are also conducting experiments designed to understand the normal cellular dialogue that occurs between some subnuclear domains. For example, it has been known for some time that Cajal bodies and another nuclear structure, known as the PML body, occasionally abut one another. We have found that CBs and PML bodies can simultaneously associate near U2 snRNA gene loci. It is possible that such an arrangement facilitates the transcription of this gene and experiments are underway to confirm this hypothesis. Additionally, since Cajal bodies are especially prevalent in cancer cells, identification and characterization of proteins that induce the formation of this structure may lead to novel cancer therapeutics. | ||
June 2010 | |||
