Hebert:Research

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[[Hebert:Research | <font face="trebuchet ms" style="color:#xxxxxx"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Hebert:Research | <font face="trebuchet ms" style="color:#xxxxxx"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Hebert:Lab pictures | <font face="trebuchet ms" style="color:#xxxxxx"> '''Lab Pictures''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Hebert:Lab pictures | <font face="trebuchet ms" style="color:#xxxxxx"> '''Lab Pictures''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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We are also conducting experiments designed to understand the normal cellular dialogue that occurs between some subnuclear domains. For example, it has been known for some time that Cajal bodies and another nuclear structure, known as the PML body, occasionally abut one another. We have found that CBs and PML bodies can simultaneously associate near U2 snRNA gene loci. It is possible that such an arrangement facilitates the transcription of this gene and experiments are underway to confirm this hypothesis. Additionally, since Cajal bodies are especially prevalent in cancer cells, identification and characterization of proteins that induce the formation of this structure may lead to novel cancer therapeutics.
We are also conducting experiments designed to understand the normal cellular dialogue that occurs between some subnuclear domains. For example, it has been known for some time that Cajal bodies and another nuclear structure, known as the PML body, occasionally abut one another. We have found that CBs and PML bodies can simultaneously associate near U2 snRNA gene loci. It is possible that such an arrangement facilitates the transcription of this gene and experiments are underway to confirm this hypothesis. Additionally, since Cajal bodies are especially prevalent in cancer cells, identification and characterization of proteins that induce the formation of this structure may lead to novel cancer therapeutics.
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June 2010
June 2010

Revision as of 16:20, 18 April 2011


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