Hee Seok Yang

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Revision as of 18:28, 18 October 2012

Research focus: Growth factor delivery, Ischemic tissue repair, Wound healing


Interests

My research is focused on controlled delivery of growth factors for the purposes of ischemic tissue repair, wound healing, cardiac and muscle tissue regeneration.


Publications

1. W.G. La, S.H. Bhang, J.Y. Shin, H.H. Yoon, J. Park, H.S. Yang, Y.E. Sung, B.S. Kim, 3,4- dihydroxyphenylalanine as a cell adhesion molecule in serum-free cell culture. Biotechnology progress 18:245-251 (2012).


2. T.J. Lee, S.H. Bhang, H.S. Yang, W.G. La, J.Y. Shin, J.Y. Seong, H.S. Shin, B.S. Kim, Enhancement of long-term angiogenic efficacy of human adipose-derived stromal cells by delivery of fibroblast growth factor 2. Microvascular Research 84:1-8 (2012).


3. S.H. Bang, J. Park, H.S. Yang, J. Shin, A.Y. Sun, B.S. Kim, Platelet-rich plasma enhances the dermal regeneration efficacy of human adipose-derived stromal cells administered to skin wound. Cell Transplantation. (Epub ahead of print).


4. H.J Park, C.Y. Heo, S. Lee, J.H. Kim, H.S. Yang, B.S. Kim, Enhancement of axial skin flap survival by sustained delivery of fibroblast growth factor 2. ANZ Journal of Surgery. (Epub ahead of print).


5. H.S. Yang, W.G. La, Y.M. Cho, W. Shin, G.D. Yeo, B.S. Kim, Comparison between heparin-conjugated fibrin and collagen sponge as bone morphogenetic protein-2 carriers for bone regeneration. Exp. Mol. Med. 44:350-355 (2012).


6. H.S. Yang, J. Park, W.G. La, H.K. Jang, M. Lee, B.S. Kim, 3,4-Dihydroxyphenylalanine- assisted hydroxyapatite nanoparticle coating on polymer scaffold for efficient osteoconduction. Tissue Engineering 18:245-251 (2012).


7. W.G. La, S.H. Kwon, T.J. Lee, H.S. Yang, J. Park, B.S. Kim, The effect of the delivery carrier on the quality of bone formed via bone morphogenetic protein-2. Artificial Organs. 36:642-647 (2012).


8. S.H. Bhang, S. Lee, T.J. Lee, W.G. LA, H.S. Yang, S.W. Cho, B.S. Kim. Three-Dimensional cell grafting enhances the angiogenic efficacy of human umbilical vein endothelial cells. Tissue Engineering 18:310-319 (2012).


9. H.S. Yang, S.H. Bhang, T.J. Lee, J.M. Kang, D.H. Lee, S.H. Lee, B.S. Kim. In situ cardiomyogenic differentiation of implanted bone marrow mononuclear cells by local delivery of transforming growth factor-ß1. Cell Transplantation 21:299-312 (2012).


10. H.J. Kim, H.W. Nam, C.Y. Hur, M. Park, H.S. Yang, B.S. Kim, J.H. Park. The effect of platelet rich plasma from bone marrow aspirate with added bone morphogenetic protein-2 on the Achilles tendon-bone junction in rabbits. Clin. Orthop. Surg. 3(4):325-331 (2011).


11. H.S. Yang, J. Shin, S.H. Bhang, J.Y. Shin, J. Park, G.I. Im, C.S. Kim, B.S. Kim. Enhanced skin wound healing by a sustained release of growth factor contained in platelet-rich plasma. Experimental and Molecular Medicine. 43:622-629 (2011).

12. H.S. Yang, W.G. La, J. Park, C.S. Kim, G.I. Im, B.S. Kim. Efficient bone formation by bone morphogenetic protein-2 released from apatite-coated collagen scaffolds. Journal of Biomaterials Science: Polymer Edition. 22(16) (2011).

13. J.W. Lee, S. Lee, S.H. Lee, H.S. Yang, G.I. Im, C.S. Kim, J.H. Park, B.S. Kim. Long-term delivery of bone morphogenetic protein-2 improves spinal fusion efficacy in a rabbit model. Acta Orthopaedica 82:756-760 (2011).

14. H.S. Yang, W.G. La, S.H. Bhang, H.J. Kim, S.J. Lee, G.I. Im, H. Lee, J.H. Park, B.S. Kim. Hyaline cartilage regeneration by a combined therapy of microfracture and a long-term delivery of BMP-2. Tissue Engineering 17:1809-1818 (2011).

15. H.S. Yang, W.G. La, S.H. Bhang, T.J Lee, M.H. Lee, B.S. Kim. Apatite-coated collagen scaffold for BMP-2 delivery. Tissue Engineering 17:2153-2164 (2011).

16. T.J. Lee, S.H. Bhang, W.G. LA, H.S. Yang, J.Y. Seong, H.S. Lee, G.I. Im, S.H. Lee, B.S. Kim. Spinner-flask culture induces redifferentiation of de-differentiated chondrocytes. Biotechnology Letters 33:829-836 (2011).

17. S.H. Bhang, S.W. Cho, W.G. La, T.J. Lee, H.S. Yang, A.Y. Sun, S.H. Baek, J.W. Rhie, B.S. Kim. Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells. Biomaterials 32:2734-2747 (2011).

18. S.H. Bhang, A.Y. Sun, H.S. Yang, T. Rhim, D.I. Kim, B.S. Kim. Skin regeneration with fibroblast growth factor 2 released from heparin-conjugated fibrin. Biotechnology Letters 33:845-851 (2011).

19. H.S. Yang, G.H. Kim, W.G. La, S.H. Bhang, T.J. Lee, B.S. Kim. Enhancement of human peripheral blood mononuclear cell transplantation-mediated bone formation. Cell Transplantation 20:1445-1452 (2011).

20. S.H. Bhang, J.H. Kim, H.S. Yang, W.G. La, T.J. Lee, G.H. Kim, H.A. Kim, M.H. Lee, B.S. Kim. Combined gene therapy with hypoxia-inducible factor-1α and heme oxygenase-1 for therapeutic angiogenesis. Tissue Engineering part A 17:915-926 (2011).

21. M.S. Kim, S.H. Bhang, H.S. Yang, N.G. Rim, I. Jun, S.I. Kim, B.S. Kim, H. Shin. Development of functional fibrous matrices for the controlled release of basic fibroblast growth factor to improve therapeutic angiogenesis. Tissue Engineering part A 16:2999-3010 (2010).

22. H.S. Yang, S.H. Bhang, J.W. Hwang, D.I. Kim, B.S. Kim. Delivery of basic fibroblast growth factor using heparin-conjugated fibrin for therapeutic angiogenesis. Tissue Engineering part A 16:2113-2119 (2010).

23. H.S. Yang, O. Jeon, S.H. Bhang, S.H. Lee, B.S. Kim. Suspension culture of mammalian cells using thermosensitive microcarrier that allows cell detachment without proteolytic enzyme treatment. Cell Transplantation 19:1123-1132 (2010).

24. W.G. La, S.W. Kang, H.S. Yang, S.H. Bhang, S.H. Lee, J.H. Park, B.S. Kim. The efficacy of bone morphogenetic protein-2 depends on its mode of delivery. Artificial Organs 34(12):1150-1153 (2010).

25. H.S. Yang, W.G. La, S.H. Bhang, J.Y. Jeon, J.H. Lee, B.S. Kim. Heparin-conjugated fibrin as an injectable system for sustained delivery of BMP-2. Tissue Engineering part A 16:1225-1233 (2010).

26. S.H. Bhang, J.H. Kim, H.S. Yang, W.G. La, T.J. Lee, G.H. Kim, M. Lee, B.S. Kim. Combined delivery of heme oxygenase-1 gene and fibroblast growth factor-2 protein for therapeutic angiogenesis. Biomaterials 30:6247-6256 (2009).

27. S.H. Bhang, S.W. Cho, J.M. Lim, J.M. Kang, T.J. Lee, H.S. Yang, Y.S. Song, M.H. Park, H.S. Kim. K.J. Yoo, Y. Jang, R. Langer, D.G. Anderson, B.S. Kim. Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs. Stem Cells 27:1976-1986 (2009).

28. S.H. Bhang, T.J. Lee, H.S. Yang, W.G. La, A.M. Han, Y.H. Kim Kwon, B.S. Kim. Enhanced nerve growth factor efficiency in neural cell culture by immobilization on the culture substrate. Biochemical and Biophysical Research Communications 382:315-320 (2009).

29.S.J. Gwak, S.H. Bhang, H.S. Yang, S.S. Kim, D.H. Lee, S.H. Lee, B.S. Kim. In vitro cardiomyogenic differentiation of adipose-derived stromal cells using transforming growth factor-β1. Cell Biochemistry and Function 27(3):148-54 (2009).

30. H.S. Yang, J.H. Seo, B.S. Kim. Serial propagation of cells on thermo-sensitive microcarrier. Tissue Engineering and Regenerative Medicine 6(13):1262-1267 (2009).

31. S.J. Lee, H.J. Kim, H.S. Yang, B.S. Kim, J.H. Park. The effects of microfracture and bone morphogenetic protein-2 on healing articular cartilage defect of the rabbit. Tissue Engineering and Regenerative Medicine 6(13):1224-1232 (2009).

32. O. Jeon, H.S. Yang, T.J. Lee, B.S. Kim. Heparin-conjugated polyethylenimine for gene delivery. Journal of Controlled Release 132(3):236-242 (2008).

33. S.W. Kang, H.S. Yang, S.W. Seo, D.K. Han, B.S. Kim. Apatite-coated poly(lactic-co-glycolic acid) microspheres as an injectable scaffold for bone tissue engineering. Journal of Biomedical Materials Research 85(A):747-756 (2008).

34. O. Jeon, S.J. Song, H.S. Yang, S.H. Bhang, S.W. Kang, M.A. Sung, J.H. Lee B.S. Kim. Long- term delivery enhances in vivo osteogenic efficacy of bone morphogenetic protein-2 compared to short-term delivery. Biochemical and Biophysical Research Communications 369:774-780 (2008).

35. H.S. Yang, K. Park, J.J. Kim, B.S. Kim, D.K. Han. Effect of bioreactor system on chondrocyte proliferation using cell adhesive PLLA-PAA-RGD scaffolds. Tissue Engineering and Regenerative Medicine 5(3):498-505 (2008).

36. S.J. Song, O. Jeon, H.S. Yang, D.K. Han, B.S. Kim. Effects of culture conditions on osteogenic differentiation in human mesenchymal stem cells. Journal of Microbiology and Biotechnology 17(7):1113-1119 (2007).

37. H.S. Yang, K. Park, J.S. Son, J.J. Kim, D.K. Han, B.W. Park, S.H. Baek. Surface modification and fibrovascular ingrowth of porous polyethylene anophthalmic implants. Macromolecular Research 15(3):256-262 (2007).

38. H.S. Yang, K. Park, B.S. Kim, J.J. Kim, K.D. Ahn, D.K. Han. In vitro chondrocyte culture using hydrophilized PLLA scaffold in bioreactor system. Key Engineering Materials 342:253-256 (2007).

39. B.W. Park, H.S. Yang, S.H. Baek, K. Park, D.K. Han, T.S. Lee. The efficacy of acrylic acid grafting and arginine-glycine-aspartic acid peptide immobilization on fibrovascular ingrowth into porous polyethylene implants in rabbits. Graefe’s Arch. Clin. Exp. Ophthalmol. 245:855-862 (2007).

40. H.S. Yang, K. Park, K.D. Ahn, B.S. Kim, D.K. Han. Optimal hydrophilization and chondrocyte adhesion of PLLA films and scaffolds by plasma treatment and acrylic acid grafting. Polymer 30(2):268-274 (2006).

41. H.S. Yang, K.D. Ahn, D.K. Han, Surface properties and cell adhesion behaviors of PLLA films and dual pore scaffolds grafted with carboxyl acids. Biomaterials Research 8(3):135-142 (2004).


Presentations


1. O. Jeon, J.M. Kang, H.S. Yang, S.J. Song, S.H. Bhang, S.W Kang, B.S. Kim. Bone morphogenetic protein-2 delivery using poly(lactic-co-glycolic acid) nanosphere for bone regeneration. The EU-Tissue Engineering & Regenerative Medicine International Society (EU-TERMIS) 2008 Porto meeting, Porto, Portugal (June 2008)

2. H.S. Yang, W.G. La, S.H. Bhang, J.Y. Jeon, J.H. Lee, B.S. Kim. Bone morphogenetic protein- 2 delivery with heparin –conjugated fibrin gel for bone regeneration. The World Congress-Tissue Engineering & Regenerative Medicine International Society (WC-TERMIS) 2009, Seoul, Korea (August 2009)

3. H.S. Yang, J.H. Shin, S.H. Bhang, T.J. Lee, M.H. Lee, B.S. Kim. Delivery of growth factors contained in platelet-rich plasma using heparin-conjugated fibrin for wound healing. The AP-Tissue Engineering & regenerative Medicine International Society (AP-TERMIS) 2010, Sydney, Australia (September 2010)

4. H.S. Yang, S.H. Bhang, D.H. Kim, B.S. Kim. In situ cardiomyogenic differentiation of implanted bone marrow mononuclear cells by heparin-conjugated PLGA nanosphere with transforming growth factor-beta 1. The International Society for Stem Cell Research (ISSCR) 2011, Toronto, Canada (June 2011)


Honors and Awards


1. Seoul Metropolitan Government Scholarship (Seoul Metropolitan Government, Seoul, Korea, 2008- 2009)

2. Best poster presentation award (The Korean Tissue Engineering and Regenerative Medicine Society, Seoul, Korea, May 2008)

3. Best article award (Graduate School, Hanyang University, Seoul, Korea, Feb 2011)

4. Best article prize (Research Institute of Industrial, Hanyang University, Seoul, Korea, Feb 2011)

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