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Journal Articles (Read in Google Scholar)

74. Wang, H., Agarwal, P., Zhao, S., Yu, J., Lu, X., and He, X. A biomimetic hybrid nanoplatform for encapsulation and precisely controlled delivery of theranostic agents. Nature Communications 2015; accepted
73. Si, T., Yin, C., Gao, P., Li, G., Ding, H., He, X., Xie, B., and Xu, R.X. Steady cone-jet mode in compound-fluidic electro-flow focusing for fabricating multicompartment microcapsules. Applied Physics Letters 2015; accepted
72. Wang, H., Yu, J., Lu, X., and He, X. Nanoparticle systems reduce systemic toxicity in cancer treatment. Nanomedicine 2015; accepted
71. Han, J., Chen, X., Chu, J., Zhang, L., Meisen, W.H., Zhang, J., He, X., Wang, Q.-E., Chiocca, E.A., Kaur, B., Caligiuri, M.A., and Yu, J. A single TGF-beta pre-treatment enhances glioblastoma virotherapy by inhibiting innate immune response. Cancer Research 2015; accepted
70. Wang, H., Agarwal, P., Zhao, S., Yu, J., Lu, X., and He, X. A near infrared laser-activated “nanobomb” for breaking the barriers to microRNA delivery. Advanced Materials 2015; Read
69. Liu, Y., Hu, X., Han, C., Wang, L., Zhang, X., He, X. and Lu, X. Targeting tumor suppressor genes for cancer therapy. BioEssays 2015; 37: 1277-1286 Read
68. Huang, H.*, Choi, J.K.*, Rao, W., Zhao, S., Agarwal, P., Zhao, G., and He, X. Alginate hydrogel microencapsulation inhibits devitrification and enables large-volume low-CPA cell vitrification. Advanced Functional Materials 2015; 25: 6839-6850 Read (*equal contribution)
67. Wang, H., Agarwal, P., Zhao, S., Xu, R.X., Yu, J., Lu, X., and He, X. Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells. Biomaterials 2015; 72: 74-89 Read
66. Huang, H. and He, X. Fluid displacement during droplet formation at microfluidic flow-focusing junctions. Lab on a Chip 2015; 15: 4197-4205 Read
65. Choi, J.K., Yue, T., Huang, H., Zhao, G., Zhang, M., and He, X. The crucial role of zona pellucida in cryopreservation of oocytes by vitrification. Cryobiology 2015; 71: 350-355 Read
64. Huang, H.*, Sun, M.*, Heisler-Taylor, T., Kiourti, A., Volakis, J., Lafyatis, G., and He, X. Stiffness-independent highly efficient on-chip extraction of cell-laden hydrogel microcapsules from oil emulsion into aqueous solution by dielectrophoresis. Small 2015; 11: 5369-5374 Read (*equal contribution)
63. Wang, Z., Zhao, G., Wang, T., Yu, Q., Su, M., and He, X. Three-dimensional numerical simulation of the effects of fractal vascular trees on tissue temperature and intracelluar ice formation during combined cancer therapy of cryosurgery and hyperthermia. Applied Thermal Engineering 2015; 90: 296-304 Read
62. Choi, J.K. and He, X. Improved oocyte isolation and embryonic development of outbred deer mice. Scientific Reports 2015; 5:12232 Read
61. Han, J., Chu, J., Chan, W.K., Zhang, J., Wang, Y., Cohen, J.B., Victor, A., Meisen, W.H., Kim, S.-H., Grandi, P., Wang, Q.-E., He, X., Nakano, I., Chiocca, E.A., Glorioso, J., Kaur, B., Caligiuri, M, and Yu, J. CAR-engineered NK cells targeting wild-type EGFR and EGFRvIII enhance killing of glioblastoma and patient-derived glioblastoma stem cells. Scientific Reports 2015; 5: 11483 Read
60. Rao, W.*, Wang, H.*, Han, J., Zhao, S., Dumbleton, J., Agarwal, P., Zhang, W., Zhao, G., Yu, J., Zynger, D.L., Lu, X., and He, X. Chitosan-decorated doxorubicin-encapsulated nanoparticle targets and eliminates tumor reinitiating cancer stem-like cells. ACS Nano 2015; 9: 5725-5740 (*equal contribution) Read
59. Agarwal, P.*, Choi, J.K.*, Huang, H., Zhao, S., Dumbleton, J., Li, J., and He, X. A biomimetic core-shell platform for miniaturized 3D cell and tissue engineering. Particle & Particle Systems Characterization 2015; 32: 809-816 (*equal contribution) Read
58. Choi, J.K., Huang, H., and He, X. Improved low-CPA vitrification of mouse oocytes using quartz microcapillary. Cryobiology 2015; 70: 269-272 Read
57. Wang, H., Zhao, S., Agarwal, P., Dumbleton, J., Yu, J., Lu, X., and He, X. Multi-layered polymeric nanoparticles for pH-responsive and sequenced release of theranostic agents. Chemical Communications 2015; 51: 7733-7736 Read
56. Liu, Y., Zhang, X., Han, C., Wan, G., Huang, X., Ivan, C., Jiang, D., Rao, P.H., Maru, D.M., Pahl, A., He, X., Sood, A.K., Ellis, L.M., Anderl, J., and Lu, X. TP53 loss creates therapeutic vulnerability in colorectal cancer. Nature 2015; 520: 697-701 Read
55. Rao, W.*, Wang, H.*, Zhong, A.*, Yu, J., Lu, X., and He, X. Nanodrug-mediated thermotherapy of cancer stem-like cells. Journal of Nanoscience and Nanotechnology 2015; 15: 1–9 (*equal contribution)
54. Zhang, W., Zhao, S., and He, X. Proliferation and differentiation of mesenchymal stem cells encapsulated in miniaturized 3D core of alginate-chitosan-alginate (ACA) microcapsules. Archives of Stem Cell Research 2015; 2: 1004-1009 Read
53. Rao, W., Huang, H., Wang, H., Zhao, S., Dumbleton, J., Zhao, G., and He, X. Nanoparticle-mediated intracellular delivery enables cryopreservation of human adipose-derived stem cells using trehalose as the sole cryoprotectant. ACS Applied Materials & Interfaces 2015; 7: 5017–5028 Read
52. Huang, H. and He, X. Interfacial tension based on-chip extraction of microparticles confined in microfluidic Stokes flows. Applied Physics Letters 2014; 105: Article No. 143704 (5 pp) Read
51. Kiourti, A., Sun, M., He, X., and Volakis, J.L. Microwave cavity with controllable temperature for in vitro hyperthermia investigations. Journal of Electromagnetic Engineering and Science 2014; 14: 267-272 Read
50. Han, C., Liu, Y., Wan, G., Choi, H.J., He, X., Zhao, L., Ivan, C., Sood, A.K., Zhang, X., and Lu, X. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression. Cell Reports 2014; 8: 1447-1460 Read
49. Deng, Y., Ren, Y., Fan, Z., Chu, J., Ji, X., Yuan, S., He, S., Hughes, T., Zhang, J., Cheema, B., Camardo, A.T., Xia, Y., Wu, L.-C., He, X., Kinghorn, D., Li, X., Caligiuri, M.A., and Yu, J. The natural product phyllanthusmin C selectively enhances IFN-gamma production by human natural killer cells through upregulation of TLR-mediated NF-kB signaling. Journal of Immunology 2014; 193: 2994-3002 Read
48. Zhao, S., Agarwal, P., Rao, W., Huang, H., Zhang, R., Liu, Z., Yu, J., Weisleder, N., Zhang, W., and He, X. Coaxial electrospray of liquid core-hydrogel shell microcapsules for encapsulation and miniaturized 3D culture of pluripotent stem cells. Integrative Biology 2014; 6: 874-884 Read
47. Rao, W.*, Zhao, S.*, Yu, J., Lu, X., Zynger, D.L., and He, X. Enhanced enrichment of prostate cancer stem-like cells with miniaturized 3D culture in liquid core-hydrogel shell microcapsules. Biomaterials 2014; 35: 7762-7773 Read (*equal contribution)
46. Yi, J., Liang, X.M., Zhao, G., and He, X. An improved model for nucleation-limited ice formation in living cells during freezing. PLoS ONE 2014; 9(5): e98132 Read
45. Choi, J.K.*, Agarwal, P.*, Huang, H.*, Zhao, S., and He, X. The crucial role of mechanical heterogeneity in regulating follicle development and ovulation with engineered ovarian microtissue. Biomaterials 2014; 35: 5122-5128 Read (*equal contribution)
44. Zhao, G., Takamatsu, H., and He, X. The effect of solution nonideality on modeling transmembrane water transport and diffusion-limited intracellular ice formation during cryopreservation. Journal of Applied Physics 2014; 115(14): 144701-13 Read
43. Chu, J., He, S., Deng, Y., Zhang, J., Peng, Y., Devine, S.M., Kwon, C.-H., He, X., Bai, X.-F., Hofmeister, C.C., and Yu, J. Genetic modification of T cells redirected towards CS1 enhances anti-myeloma activity. Clinical Cancer Research 2014; 20: 3899-3901 Read
42. Rao, W., Zhang, W., Poventud-Fuentes, I., Wang, Y., Lei, Y., Agarwal, P., Weekes, B., Li, C., Lu, X., Yu, J., and He, X. Thermally responsive nanoparticle-encapsulated curcumin and its combination with mild hyperthermia for enhanced cancer cell destruction. Acta Biomaterialia 2014; 10: 831-842 Read
41. He, S., Deng, Y., Vasu, S., Chu, J., Zhang, J., Fan, Z., He, X., Marsh, H., Devine, S. M., and Yu, J. FLT3L and Plerixafor combination increases hematopoietic stem cell mobilization and leads to improved transplantation outcome. Biology of Blood and Marrow Transplantation 2014; 20: 309-313 Read
40. Rao, W., Bellotti, A., Littrup, P.J., Yu, J., Lu, X., and He, X. Nanoparticle-encapsulated doxorubicin enhances cryoablation of cancer stem-like cells. Technology 2014; 2: 28-35 Read
39. Chu, J., Deng, Y., Benson, D. M. (Jr.), He, S., Hughes, T., Zhang, J., Peng, Y., Mao, H., Yi, L., Ghoshal, K., He, X., Devine, S. M., Zhang, X., Caligiuri, M.A., Hofmeister, C. C., and Yu, J. CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo anti-tumor activity against human multiple myeloma. Leukemia 2014; 28: 917-927 Read
38. Choi, J.K., Agarwal, P., and He, X. In vitro culture of early secondary preantral follicles in hanging drop of ovarian cell-conditioned medium to obtain MII oocytes from outbred deer mice. Tissue Engineering Part A 2013; 19: 2626-2637 Read
37. Agarwal, P., Zhao, S., Bielecki, P., Rao, W., Choi, J.K., Zhao, Y., Yu, J., Zhang, W., and He, X. One-step microfluidic generation of pre-hatching embryo-like core-shell microcapsules for miniaturized 3D culture of pluripotent stem cells. Lab on a Chip 2013; 13: 4525-4533 Read
36. He, S., Chu, J., Wu, L.-C., Mao, H., Peng, Y., Alvarez-Breckenridge, C.A., Hughes, T., Wei, M., Zhang, J., Yuan, S., Sandhu, S., Vasu, S., Benson (Jr.), D.M., Hofmeister, C., He, X., Ghoshal, K., Devine, S.M., Caligiuri, M.A., and Yu, J. MicroRNAs activate natural killer cells through toll-like receptor signaling. Blood 2013; 121(23): 4663-4671 Read
35. Choi, J.K. and He, X. In vitro maturation of cumulus-oocyte complexes for efficient isolation of oocytes from outbred deer mice. PLoS ONE 2013; 8(2): e56158 Read
34. Yu, J., Peng, Y., Wu, L.-C., Xie, Z., Deng, Y., Hughes, T., He, S., Mo, X., Chiu, M., Wang, Q.-E., He, X., Liu, S., Grever, M.R., Chan, K.K., and Liu, Z. Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia. PLoS ONE 2013; 8(2): e55934 Read
33. Zhang, W.*, Zhao, S.*, Rao, W., Snyder, J., Choi, J.K., Wang, J., Khan, I.A., Saleh, N.B., Mohler, P.J., Yu, J., Hund, T.J., Tang, C., and He, X. A novel core-shell microcapsule for encapsulation and 3D culture of embryonic stem cells. Journal of Materials Chemistry B 2013; 1(7): 1002-1009 (*equal contribution) Read
32. Wang, J., Chen, Y., Yao, K., Wilbon, P.A., Zhang, W., Ren, L., Zhou, J., Nagarkatti, M., Wang, C., Chu, F., He, X., Decho, A.W., and Tang, C. Robust antimicrobial compounds and polymers derived from natural resin acids. Chemical Communications 2012; 48: 916-918 Read
31. Zhang, W. and He, X. Microencapsulating and banking living cells for cell-based medicine. Journal of Healthcare Engineering 2011; 2: 427-446 Read
30. Yao, K., Wang, J., Zhang, W., Lee, J.S., Wang, C., Chu, F., He, X., Tang, C. Degradable rosin ester-caprolactone graft copolymers, Biomacromolecules 2011; 12: 2171-2177 Read
29. He, X. Thermostability of biological systems: Fundamentals, challenges, and quantification. The Open Biomedical Engineering Journal 2011; 5: 47-73 Read
28. Gilstrap, K., Hu, X., Lu, X., and He, X. Nanotechnology for energy-based cancer therapies. American Journal of Cancer Research 2011; 1(4): 508-520 Read
27. Zhang, X., Wan, G., Berger, F.G., He, X., and Lu, X. The ATM kinase induces microRNA biogenesis in DNA damage. Molecular Cell 2011; 41: 371-383 Read
26. Yang, G., Veres, M., Szalai, G., Zhang, A., Xu, L.X., and He, X. Biotransport phenomena in freezing mammalian oocytes. Annals of Biomedical Engineering 2011; 39(1): 580-591 Read
25. Zhang, W., Gilstrap, K., Wu, L., K.C., R. B., Moss, M. A., Wang, Q., Lu, X., and He, X. Synthesis and characterization of thermally responsive Pluronic F127-chitosan nanocapsules for controlled release and intracellular delivery of small molecules. ACS Nano 2010; 4(11): 6747-6759 Read
24. Yang, G., Gilstrap, K., Zhang, A., Xu, L.X., and He, X. Collapse temperature of solutions important for lyopreservation of living cells at ambient temperature. Biotechnology and Bioengineering 2010; 106(2): 247-259 Read
23. Zhang, W.*, Yang, G.*, Zhang, A., Xu, L.X., and He, X. Preferential vitrification of water in small (~100 µm) alginate microcapsules significantly augments cell cryopreservation by vitrification. Biomedical Microdevices 2010; 12(1): 89-96 (*equal contribution) Read
22. Zhang, W., Rong, J, Wang, Q., and He, X. The encapsulation and intracellular delivery of trehalose using a thermally responsive nanocapsule. Nanotechnology 2009; 20(27): Article No. 275101 (14pp) Read
21. Zhang, W. and He, X. Encapsulation of living cells in small (~100 µm) alginate microcapsules by electrostatic spraying: a parametric study. Journal of Biomechanical Engineering 2009; 131: Article No. 074515 (6pp) Read
20. Yang, G., Zhang, A., Xu, L.X., and He, X. Modeling the cell type dependence of diffusion-limited intracellular ice nucleation and growth: Implications for cell cryopreservation by both vitrification and slow freezing. Journal of Applied Physics 2009; 105: Art. No. 114701 (11 pp) Read
19. He, X., Bhowmick, S., and Bischof, J.C. Thermal therapy in urologic systems: A comparison of Arrhenius and thermal isoeffective dose (TID) models in predicting hyperthermic injury. Journal of Biomechanical Engineering 2009; 131: Article No. 074507 (12pp) Read
18. Li, D. and He, X. Desiccation induced structural alterations in a 66-amino acid fragment of an anhydrobiotic nematode late embryogenesis abundant (LEA) protein. Biomacromolecules 2009; 10: 1469-1477 Read
17. He, X., Fowler, A., Menze, M., Hand, S., and Toner, M. Desiccation kinetics and biothermodynamics of trehalose solutions in thin films: Implication for lyopreservation. Annals of Biomedical Engineering 2008; 36(8): 1428-1439 Read
16. He, X., Park, E., Fowler, A., Yarmush, M., and Toner, M. Vitrification by ultra-fast cooling at a low concentration of cryoprotectants in a quartz microcapillary: A study using murine embryonic stem cells. Cryobiology 2008; 56(3): 223-232 Read
15. Risco, R., Elmoazzen, H., Doughty, M., He, X., and Toner, M. Thermal performance of quartz capillaries for vitrification. Cryobiology 2007; 55(3): 222-229 Read
14. He, X., Fowler, A., and Toner, M. Water activity and mobility in solutions of glycerol and small molecular weight sugars: Implication for cryo- and lyo- preservation. Journal of Applied Physics 2006; 100 (7): Art. No. 074702 (11 pp) Read
13. He, X., Amin, A., Fowler A., and Toner, M. Thermally induced introduction of trehalose into primary rat hepatocytes. Cell Preservation Technology 2006; 4(3): 178-187 Read
12. Aksan, A., Irimia, D., He, X., and Toner, M. Desiccation kinetics of biopreservation solutions in micro-channels. Journal of Applied Physics 2006; 99 (6): Art. No. 064703 (9 pp) Read
11. He, X. and Bischof, J. C. Analysis of thermal stress in cryosurgery of kidneys. Journal of Biomechanical Engineering 2005; 127(4): 656-661 Read
10. Bischof, J. C. and He, X. Thermal stability of proteins. Annals of the New York Academy of Sciences 2005; 1066: 12-33 Read
    
9. He, X. and Bischof, J. C. The kinetics of thermal injury in human renal carcinoma cells. Annals of Biomedical Engineering 2005; 33(4): 502-510 Read
8. He, X., Wolkers, W. F., Crowe, J. H., Swanlund D. J., and Bischof J. C. In situ thermal denaturation of proteins in dunning AT-1 prostate cancer cells: Implication for hyperthermic cell injury. Annals of Biomedical Engineering 2004; 32(10): 1384-1398 Read
7. He, X., McGee, S., Coad, J. E., Schmidlin, F., Iaizzo, P. A., Swanlund, D. J., Rudie, E., Kluge, S. and Bischof, J. C. Investigation of the thermal and tissue injury behavior in microwave thermal therapy using a porcine kidney model. International Journal of Hyperthermia 2004; 20(6): 567-593 Read
6. Chao, B. H., He, X., and Bischof, J. C. Pre-existing inflammation induced by TNF-α augments cryosurgical injury on human prostate cancer. Cryobiology 2004; 49(1): 10-27 Read
5. He, X. and Bischof, J. C. Quantification of temperature and injury in thermal therapy and cryosurgery. Critical Reviews in Biomedical Engineering 2003; 31(5): 355-421 Read
4. He, X., Zhang, R., Wang, S., Shang, C., and Yu, B. Computational simulation and experimental verification of the refrigeration system in inverter air-conditioners. Heating Ventilation & Air Conditioning 2001; 31: 43-48 Read
3. He, X., Zhang, R., Wang, S., Shang, C., and Yu, B. Computational simulation and experimental verification of reciprocation type refrigeration compressor. Journal of Beijing University of Technology 2001; 27(1): 104-107 Read
2. He, X., Wang, Z., and Yu, B. Performance analysis of small capacity inverter air conditioner using a single capillary for throttling. Fluid Machinery 1998; 12: 47-50 Read
1. Yu, B., Wang, Z., and He, X. Effect of refrigerant charge on the performance of the refrigeration system in inverter air conditioner and its determining principle. Fluid Machinery 1998; 9: 52-56 Read

Books

1. He, X. and Bischof, J. (Editors) Multiscale Technologies for Cryomedicine-Implementation from Nano to Macroscale. Singapore: World Scientific Publishers/Imperial College Press, 2015; in press link

Book Chapters

3. Huang, H. and He, X. Microscale materials and devices for cell cryopreservation by vitrification. In Multiscale Technologies for Cryomedicine-Implementation from Nano to Macroscale, Editors: He, X. and Bischof, J.; Singapore: World Scientific Publishers/Imperial College Press, in press, 2015 link
2. He, X., Rao, W., and Wang, H. Polymeric nanoparticles for cryobiological applications. In Multiscale Technologies for Cryomedicine-Implementation from Nano to Macroscale, Editors: He, X. and Bischof, J.; Singapore: World Scientific Publishers/Imperial College Press, in press, 2015 link
1. He, X. Preservation of embryonic stem cells. In Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications, Editor: Atwood, C.; Vienna, Austria: InTech Publisher, pp113-138, 2011 Link