Hoatlin:OHSU Knight Cancer Institute Advanced Topics in Cancer Biology

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Objectives of the Advanced Topics in Cancer Biology class (CELL 616)

This upper level course will provide clinical insight into cancer research. We have designed this course to address mechanism and current therapeutic options for cancer treatment in the first part of the course. The second part of the course is designed to examine the current state of clinical diagnoses and treatment of different types of cancers that afflict different organ systems. These lectures are designed to address the state of the art and to provide insight into where the field is moving in the future. The overall goal of this course is to provide the current state of the field from a clinical standpoint in anticipation that this knowledge will then be applied to guiding important findings in basic research.

Logistics

• When and where we meet

RJH 5501

The class will run every Spring term

Mon, Wed: 1:30-3:00 PM; Thurs: 1:30-2:30 PM

Mon, Wed class is one hour lecture followed by discussion, Thurs class is presentation of a relevant journal article

• Organizer contact information: searsrATohsu.edu, wongmeATohsu.edu

Participants, Expectations and Grading

The class is open for registration to all second year and above students. The class is also open to postdoctoral fellows for informal auditing. Please contact the organizers with any questions regarding participation.

Participants are required to attend at least one tumor board meeting of their choice:

1. Gastrointestinal Tumor Board 7a, Thursday, Hatfield 14D03 (occasionally is canceled)

2. Breast Tumor Board 8:30a, Thursday, Hatfield 14D03

3. Hem/Onc Tumor Board 8a, Wednesday, Hatfield 14D03 Lymphoma, leukemia alternate every other week (occasionally not held if an outside speaker is scheduled)

4. Sarcoma tumor board 12:30-1:30, Wednesday, Hatfield 14D03 (except for the 4th Wednesday of each month)

Each participant will do a tumor board presentation as follows:

20 minutes in length, powerpoint presentation format

Include: 1. Background (cancer type, stage, grade, what is known about this cancer)

2. Known molecular pathways underlying the disease and any potential therapeutic treatments

3. Present the issues discussed related to the individual patient you will be discussing

4. What was the course of actions? And follow-up? Prognosis?

5. Your insights or interests pertaining to this case.

For students, your grade will be based upon three criteria:

1. Class participation (30%) Your journal presentation participation and how interactive you are during the lecture

2. Your tumor board presentation (30%)

3. Final Exam (40%) This exam is a written review of one cancer type (your choice).

Within this review you will include information addressing: background on this type of cancer, demographics, current therapies, known molecular mechanisms, molecular and animal models that exist, cutting edge research being performed to elucidate the underlying molecular pathway and/or development of novel therapeutics.

Schedule

• Scheduling In Progress

Date	Presenters	Topic	Links & Comments
10/02/2008	Sears and Lopez	Organization	http://openwetware.org/wiki/Oregon_Cancer_Institute_Research_Groups:OCI_Cancer_Journal_Club
10/09/2008	Julie Escamilla-Powers
10/16/2008	Jon Oyer
10/23/2008	Branden Tarlow
10/30/2008	Phil Streeter	CSC	Recommended references: Nature Reviews, Cancer; Pardal, R, Clarke, MF & Morrison, SJ., p 895-902, Dec 2003. Nature Reviews, Cancer; Visvader, JA & Lindeman, GJ, Vol 8, p 755-768, 2008.
11/06/2008	Kevan Shokat, PhD	"Chemical genetic analysis of the PI3K-mTor pathway"	Phys/Pharm seminar
11/13/2008	Sarah Byers
11/20/2008	Katy Van Hook
12/04/2008	Ashleigh Miller		Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. Nature. 2008 Oct 30;455(7217) http://www.nature.com/nature/journal/v455/n7217/abs/nature07284.html
12/11/2008	Trevor Levin
01/08/2009	Jodi Johnson
01/15/2009	Peggy Chang
01/22/2009	CANCELLED FOR OHSU TOWN HALL MEETING
01/29/2009	Nate Donley
02/05/2009	Devo Goldman
02/12/2009	Deanne Tibbitts		Quintana, et al. Efficient tumour formation by single human melanoma cells. Nature. 2008 Dec 4;456(7222):593-8. http://www.nature.com/nature/journal/v456/n7222/abs/nature07567.html
02/19/2009	Amy Farrell
02/26/2009	Xiaoli Zhang
03/05/2009	Cancelled due to Dr. Jenny Chang talk
03/12/2009	Jeffrey Wu
03/19/2009	Xiangshu Xiao
04/02/2009	Vince Bicocca
04/09/2009	Vivain Wu
04/16/2009	David Qian
04/23/2009	Yun Yin Lim
04/30/2009	Ali Macleod
05/14/2009	Jayme Gallegos
05/21/2009	Aaron Wortham
05/28/2009	Arun Kumar
06/04/2009	Ashley Kamimae-Lanning
06/11/2009	Charlie Lopez